Ovarian endometrioid tumors mimicking sertoli and sertoli-leydig cell tumors. Sertoliform variant of endometrioid carcinoma

Roth, Lawrence M.; Liban, E; Czernobilsky, Bernard

doi:10.1002/1097-0142(19821001)50:7<1322::aid-cncr2820500718>3.0.co;2-c

Cited by 82 publications

(42 citation statements)

References 8 publications

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“…31 In yet other cases, endometrioid carcinomas may show focal to extensive areas resembling Sertoli and Sertoli-Leydig cell tumors ( Figure 13). [31][32][33] They contain small, well-differentiated hollow tubules, solid tubules or, rarely, thin cords resembling sex cords. When the stroma is luteinized, this variant may be mistaken for a Sertoli-Leydig cell tumor, particularly in cases in which the patient is virilized (Figure 14).…”

Section: Metastatic Colon Cancer Of Non-mucinous Typementioning

confidence: 99%

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Prat

2005

Mod Pathol

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The differential diagnosis of ovarian carcinomas, including secondary tumors, remains a challenging task. Mucinous carcinomas of the ovary are rare and can be easily confused with metastatic mucinous carcinomas that may present clinically as a primary ovarian tumor. Most of these originate in the gastrointestinal tract and pancreas. International Federation of Gynecology and Obstetrics (FIGO) stage is the single most important prognostic factor, and stage I carcinomas have an excellent prognosis; FIGO stage is largely related to the histologic features of the ovarian tumors. Infiltrative stromal invasion proved to be biologically more aggressive than expansile invasion. Metastatic colon cancer is frequent and often simulates ovarian endometrioid adenocarcinoma. Although immunostains for cytokeratins 7 and 20 can be helpful in the differential diagnosis, they should always be interpreted in the light of all clinical information. Occasionally, endometrioid carcinomas may exhibit a microglandular pattern simulating sex cord-stromal tumors. However, typical endometrioid glands, squamous differentiation, or an adenofibroma component are each present in 75% of these tumors whereas immunostains for calretinin and alpha-inhibin are negative. Endometrioid carcinoma of the ovary is associated in 15-20% of the cases with carcinoma of the endometrium. Most of these tumors have a favorable outcome and they most likely represent independent primary carcinomas arising as a result of a Mü llerian field effect. Although the criteria for distinguishing metastatic from independent primary carcinomas rely mainly upon conventional clinicopathologic findings, loss of heterozygosity and gene mutation analyses can be helpful. Transitional cell carcinomas are distinguished from undifferentiated carcinomas by the presence of thick, undulating papillae with smooth luminal borders, microspaces, and tumor cells with distinctive 'urothelial' appearance. Krukenberg tumors are metastatic adenocarcinomas traditionally perceived as composed of mucin-filled signet-ring cells associated with a striking proliferation of the ovarian stroma but many variations on this pattern occur.

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Section: Metastatic Colon Cancer Of Non-mucinous Typementioning

confidence: 99%

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Prat

2005

Mod Pathol

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“…SEC is a rare variant of endometrioid adenocarcinoma, most of which were reported in the ovary and rare cases in the endometrium (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). It causes important diagnostic difficulties for the pathologist due to its morphologic resemblance to sex cord stromal tumors, especially sertoli cell tumor and sertoli leydig cell tumor.…”

Section: Discussionmentioning

confidence: 99%

Ovarian sertoliform endometrioid adenocarcinoma: A rare variant which causes diagnostic pitfalls

Kankaya¹,

Kahraman²,

Ortaç³

et al. 2015

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Sertoliform endometrioid carcinoma (SEC) is a rare variant of endometrioid adenocarcinoma, which causes diagnostic pitfalls due to its morphologic resemblance of sex cord stromal tumors. Herein, we report a case of SEC in the ovary almost all of which consisted of sex-cord like areas and was presumed to be a sertoli cell tumour initially. Immunohistochemical features incompatible with sertoli cell tumour were alerting and extensive sampling revealed a focal component of classical endometrioid carcinoma with anastomosing cribriform areas of more columnar cells. The final diagnosis was sertoliform endometrioid adenocarcinoma. This entity should be kept in mind for all the pathologists and gynaecologic oncologists. Sampling such tumours extensively and confirming the diagnosis by immunohistochemistry using a large antibody panel is requisite for the correct diagnosis and preventing the patient from inappropriate therapies.

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“…Only three articles describing cases encountered with this uncommon neoplasm have been reported in the literature [1,4,8]. Generally, the tumour occurs in post-menopausal patients, with an average age of 68 years [8], whereas SCT and SLCT are usually encountered in younger patients, with an average age of 28 years [5].…”

Section: Discussionmentioning

confidence: 99%

“…This malignant tumour is reported to have an incidence of approximately 20% and is considered to be the second most frequent primary ovarian tumour after the serous cystadenocarcinoma [2,4].…”

Section: Introductionmentioning

confidence: 99%

“…Exceptionally, EC is char- and Sertoli-Leydig cell tumours (SLCT). Twenty-one tumours of this type have been reported in the literature [1,4,8]. Their denomination is purely descriptive: "ovarian endometrioid tumour mimicking Sertoli and Sertoli-Leydig cell tumors", "sertoliform variant of endometrioid carcinoma" (SEC) [4] and "ovarian endometrioid carcinomas resembling sex-cord stromal tumours" [1].…”

Section: Introductionmentioning

confidence: 99%

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Ovarian sertoliform endometrioid carcinoma

Remadi

Ismail²,

Tawil³

et al. 1995

Vichows Archiv A Pathol Anat

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Sertoliform endometrioid carcinoma (SEC) is a rare ovarian neoplasm occurring almost exclusively in post-menopausal patients. We studied a 71-year-old patient who underwent a total hysterectomy with bilateral salpingo-oophorectomy for a right ovarian mass measuring 25 cm in its maximal dimension. Histology revealed an SEC, featuring foci of typical endometrioid carcinoma and areas of clear cell differentiation. This particular type of ovarian neoplasm, already described in 21 reported cases in the literature, must be distinguished from Sertoli cell tumours and Sertoli-Leydig cell tumours which are encountered at a younger age. We discuss the elements of the differential diagnosis and insist upon the value of anti-epithelial membrane antigen in identifying an SEC.

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Ovarian endometrioid tumors mimicking sertoli and sertoli-leydig cell tumors. Sertoliform variant of endometrioid carcinoma

Cited by 82 publications

References 8 publications

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Ovarian sertoliform endometrioid adenocarcinoma: A rare variant which causes diagnostic pitfalls

Ovarian sertoliform endometrioid carcinoma

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