Ovarian sertoliform endometrioid carcinoma

Remadi, Sami; Ismail, Adel Mohamed; Tawil, Ayman; Gee, William Mac

doi:10.1007/bf00193179

Cited by 8 publications

(5 citation statements)

References 7 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of previous reports 17,24,31,36,42,43,47,50 have highlighted the extent to which ECs of the ovary and fallopian tube can exhibit a morphologic spectrum that can include epithelial formations with sex cord-like patterns as well as spindled carcinomatous cells. The unusual feature of our cases that sets them apart from most ECs of the ovary and tube is the striking stromal hyalinization that occasionally undergoes osteoid metaplasia and is typically associated with cords of cells.…”

Section: Discussionmentioning

confidence: 98%

“…The most common of such variants are ovarian ECs in which sex cord-like patterns can cause confusion with sex cord-stromal tumors. 24,31,42,43,50 A few examples of sertoliform ECs have also been described in the endometrium. 20,48 Another unusual finding in ECs, one that may cause confusion with a malignant mullerian mixed tumor (MMMT), is the presence of spindled epithelial cells.…”

mentioning

confidence: 95%

See 1 more Smart Citation

Endometrioid Carcinomas of the Uterine Corpus With Sex Cord-like Formations, Hyalinization, and Other Unusual Morphologic Features

Murray

Clement²,

Young³

2005

American Journal of Surgical Pathology

113

View full text Add to dashboard Cite

We describe a series of unusual endometrioid carcinomas (ECs) of the uterine corpus characterized in significant part by cords of epithelioid cells, spindle cells, and a hyalinized stroma that sometimes formed osteoid. These features, particularly when prominent, produced an appearance strikingly different from that of conventional EC, sometimes resulting in problems in differential diagnosis, especially with a malignant mullerian mixed tumor (carcinosarcoma). The 31 patients ranged in age from 25 to 83 years (mean, 52 years). The proportion within each stage were as follows: stage Ia, 9.7%, stage Ib, 45.2%, stage Ic, 9.7%, stage IIb, 16.1%, stage IIIc 3.2%, and stage IV, 3.2%. In 4 patients (12.9%), staging information was not available. On microscopic examination, typical EC, which accounted for 10% to 90% of the tumor, was admixed in 90% of cases with cords of epithelioid or spindle cells within a hyalinized stroma. In 3 cases, the tumor contained cords of cells without a hyalinized stroma. Areas with a diffuse growth of fusiform cells suggesting endometrial stromal cells were also occasionally seen in minor amounts. Seventy percent of the tumors exhibited squamous differentiation, and in 50% of the tumors there was a background of endometrial hyperplasia. Two thirds of the tumors were grade 2 and the remainder were grade 1. Vascular space invasion was identified in seven tumors. On immunohistochemical analysis, the typical EC component was strongly positive for keratin, whereas the keratin staining was more focal and variable in the epithelial cells in the cords. Muscle markers (desmin, actin), CD10, and inhibin were negative in the latter. Overexpression of p53 was found in only 1 case. Eighty-three percent of the patients were alive with no evidence of disease on follow-up (range, 2-115 months; mean, 34.4 months). The clinical features, including a typically low stage and generally good prognosis, and histologic findings are different from those of malignant mullerian mixed tumors that are characterized by both high-grade carcinomatous and sarcomatous components and an aggressive clinical course. Confusion with other neoplasms, particularly those with sex cord-like growth, such as uterine tumors resembling ovarian sex cord tumors and epithelioid smooth muscle tumors, may also arise. We refer to tumors with the features described herein as "corded and hyalinized endometrioid carcinomas," a designation that reflects their two most striking and consistent features. Corded and hyalinized endometrioid carcinomas are yet another example of the protean phenotype of endometrioid adenocarcinomas of the female genital tract that has been appreciated only in the last two decades.

show abstract

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 95%

Endometrioid Carcinomas of the Uterine Corpus With Sex Cord-like Formations, Hyalinization, and Other Unusual Morphologic Features

Murray

Clement²,

Young³

2005

American Journal of Surgical Pathology

113

View full text Add to dashboard Cite

show abstract

“…SECs almost exclusively arise in postmenopausal women, with an average age of diagnosis between 60 and 70 years. In contrast, patients with SLCT tend to be younger, with an average age of diagnosis of 25 years, and may have hormonal signs, such as virilization [ 26 ]. Correspondingly, the 2 patients who were finally diagnosed with SEC in this study were relatively old.…”

Section: Discussionmentioning

confidence: 99%

A novel clinicopathological analysis of early stage ovarian Sertoli-Leydig cell tumors at a single institution

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo evaluate the clinical and pathologic characteristics of patients who were diagnosed with ovarian Sertoli-Leydig cell tumors (SLCTs) in a single institution.MethodsThe medical records of 11 patients who were pathologically diagnosed with SLCTs beginning in 1995 in a single institute was reviewed.ResultsThe median patient age was 31 years (range, 16 to 70 years). Patient International Federation of Gynecology and Obstetrics stages were IA, IC, and IIB in 3 (27.3%), 6 (54.5%), and 2 (18.2%) patients, respectively. Six patients (54.5%) had grade 3 tumors, 3 patients (27.3%) had grade 2 tumors, and 1 patient (9.1%) had a grade 1 tumor. Four patients without children underwent fertility-sparing surgery, and 7 patients had full staging surgery, including a hysterectomy and bilateral salpingo-oophorectomy, with a laparoscopic approach used in 3. Eight patients underwent pelvic lymph node dissection, and 8 patients were administered adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin in 6 cases, a modified bleomycin, etoposide, and cisplatin regimen in 1 case, and a combined paclitaxel and cisplatin regimen in 1 case. Two patients died of disease and were re-diagnosed with Sertoli form endometrioid carcinoma. The other patients remain alive without recurrence at the time of reporting.ConclusionOur findings suggest that regardless of tumor stage or grade, ovarian SLCT patients have a good prognosis. Close observation and unilateral salpingo-oophorectomy would be beneficial for women who still wish to have children, while hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy would be the optimal treatment in other cases. Furthermore, meticulous pathologic diagnosis is needed to develop a precise treatment strategy.

show abstract

“…SEC is a rare variant of endometrioid adenocarcinoma, most of which were reported in the ovary and rare cases in the endometrium (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). It causes important diagnostic difficulties for the pathologist due to its morphologic resemblance to sex cord stromal tumors, especially sertoli cell tumor and sertoli leydig cell tumor.…”

Section: Discussionmentioning

confidence: 99%

Ovarian sertoliform endometrioid adenocarcinoma: A rare variant which causes diagnostic pitfalls

Kankaya¹,

Kahraman²,

Ortaç³

et al. 2015

Ankara Üniversitesi Tıp Fakültesi Mecmuası

View full text Add to dashboard Cite

Sertoliform endometrioid carcinoma (SEC) is a rare variant of endometrioid adenocarcinoma, which causes diagnostic pitfalls due to its morphologic resemblance of sex cord stromal tumors. Herein, we report a case of SEC in the ovary almost all of which consisted of sex-cord like areas and was presumed to be a sertoli cell tumour initially. Immunohistochemical features incompatible with sertoli cell tumour were alerting and extensive sampling revealed a focal component of classical endometrioid carcinoma with anastomosing cribriform areas of more columnar cells. The final diagnosis was sertoliform endometrioid adenocarcinoma. This entity should be kept in mind for all the pathologists and gynaecologic oncologists. Sampling such tumours extensively and confirming the diagnosis by immunohistochemistry using a large antibody panel is requisite for the correct diagnosis and preventing the patient from inappropriate therapies.

show abstract

Ovarian sertoliform endometrioid carcinoma

Cited by 8 publications

References 7 publications

Endometrioid Carcinomas of the Uterine Corpus With Sex Cord-like Formations, Hyalinization, and Other Unusual Morphologic Features

Endometrioid Carcinomas of the Uterine Corpus With Sex Cord-like Formations, Hyalinization, and Other Unusual Morphologic Features

A novel clinicopathological analysis of early stage ovarian Sertoli-Leydig cell tumors at a single institution

Ovarian sertoliform endometrioid adenocarcinoma: A rare variant which causes diagnostic pitfalls

Contact Info

Product

Resources

About