Ovarian carcinoma arising in endometriosis

Malignant Transformation of Ovarian Endometriosis

“…It has been pointed out that the coexistence of endometriosis with clear cell or endometrioid carcinoma is much more common than with other histologic types of ovarian cancer [9,10]. Corner et al [1] investigated the association between ovarian cancer and ovarian endometriosis by studing 262 cases of ovarian cancer and 889 cases of ovarian endometriosis. They reported that six malignant neoplasms represented 2.3% of ovarian cancers associated with endometriosis, but only 0.7% of ovarian endometriosis.…”

“…However, it has been reported that some ovarian cancer arises from ovarian endometriosis. Corner et al [1] and Scully et al [2] reported that malignant change occurred in 6 of 889 (0.7%) and 8 of 950 (0.8%) cases of ovarian endometriosis, respectively. Endometrioid and clear cell adenocarcinomas are most the common histologic types of ovarian cancer arising in ovarian endometriosis.…”

A case of clear cell carcinoma arising from the endometriosis of the paraovarian cyst

“…6 However, about 0.7-1.0% of patients with endometriosis have lesions that undergo malignant transformation. 2,3 Heap et al 4 reviewed 205 reported cases of malignancy arising in endometriosis and reported that the ovary was the most frequently involved, accounting for 165 cases (78.7%), and that extragonadal tumors were present in 44 (21.3%). The rectovaginal septum, colon, vagina, and pelvic peritoneum represented the majority of extragonadal sites.…”

“…About 0.7-1.0% of patients with endometriosis have lesions that undergo malignant transformation. 2,3 In 79% of the cases, the ovary is the primary site of malignancy, whereas extragonadal sites represent 21% of tumors. 4 There has been 1 documented case of clear cell carcinoma arising in vulva endometriosis.…”

Diagnostics and Therapy for Malignant (Degenerate) Colon Endometriosis – Three Case Reports

“…Corner and co-workers [3] additionally required histological evidence for a gradual transition from benign to malignant structures. Beside the genital manifestations, an extragenital endometrial attack is found in up to 30% of the cases.…”