A case of clear cell carcinoma arising from the endometriosis of the paraovarian cyst

Lee, Jung‐Yun; Im, Eun Seon; Kim, Sang–Wook; Kim, Haeryoung; Kim, Yong-Beom; Jeon, Yung Jin

doi:10.3802/jgo.2009.20.1.60

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…A statistically significant negative correlation between BMPR2 and BMP-2 concentrations, demonstrated through the absence of a statistically significant correlation between the concentrations of this receptor and BMP-7, may suggest that the BMPR2 receptor has a greater affinity for the BMP-2 molecule than BMP-7. Lee et al [18] observed that bone morphogenetic protein receptors present on the surface of cells, before binding to the soluble form of the ligand, occur in the form of homomeric, as well as heteromeric, complexes and have low expression. However, upon ligand attachment, most BMP receptors form heteromeric complexes, and the expression of these receptors significantly increases.…”

Section: Discussionmentioning

confidence: 99%

Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis

Janusz

Kondera-Anasz

et al. 2021

Biomedicines

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Angiogenesis is considered to be one of the key stages in the development of endometriosis. Recent studies indicate that bone morphogenetic proteins (BMPs) and their receptors (BMPR) may play an important role in the angiogenesis process. In the literature, however, there is a lack of publications concerning binding BMPs and their receptors with the pathogenesis of endometriosis. The aim of the study was to determine the role of soluble bone morphogenetic proteins, BMP-2 and BMP-7, and their receptors, ALK-1 and BMPR2, in the process of the formation and development of endometriosis. Peritoneal fluid was collected in the proliferative phase of the menstrual cycle, from 80 women aged 21–49 years (mean age 31.3 ± 6.7 years) undergoing laparoscopy to determine the causes of primary infertility. The study involved 60 women in the I, II, III, and IV stages of the disease. The reference group consisted of 20 women who did not have endometriosis or other lesions in the pelvic area. The concentration in the peritoneal fluid of women with endometriosis was compared to the concentration of this parameter in the reference group, and a statistically significant reduction in the concentration of the BMP-2 molecule was found, as well as increasing concentrations of BMP-7, ALK-1, and BMPR2. BMP-2 and BMP-7 and their soluble receptors, ALK-1 and BMPR2, are involved in the formation of endometriosis. The changes in the concentrations of most of the tested parameters demonstrated in the study, especially in the early stages of the disease, may indicate the more effective formation of new blood vessels in this period.

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Section: Discussionmentioning

confidence: 99%

Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis

Janusz

Kondera-Anasz

et al. 2021

Biomedicines

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Adenocarcinoma mucinoso del paraovario: un tumor infrecuente

Tato-Varela

Palacios

Polo-Velasco

et al. 2015

Progresos de Obstetricia y Ginecología

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Appendectomy in retrograde order for complete removal of endometriosis

Lim

Song

Lee

et al. 2009

Gynecological Endocrinology

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Endometriosis frequently involves the intestines. Appendectomy would be often required as part of complete removal of endometriosis. We present a patient with endometriosis who required very difficult appendectomy. For complete removal of endometriosis, hysterectomy, bilateral salpingooophorectomy, low anterior resection and accompanying pelvic peritonectomy were performed through a mid-line incision. Unexpectedly, the appendiceal tip was attached to peri-hepatic tissue with the appendix adhered to the surrounding peritoneum and bowel. Completion of the appendectomy was possible in retrograde order after extension of the surgical incision above the umbilicus. Our findings suggest that preoperative image evaluation for location or position of the appendix might be helpful in patients with suspected endometriosis to offer correct counselling, obtaining adequate consent, determining the optimal surgical approach and scheduling opportune intraoperative consultation by a colorectal surgeon.

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A case of clear cell carcinoma arising from the endometriosis of the paraovarian cyst

Cited by 3 publications

References 12 publications

Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis

Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis

Adenocarcinoma mucinoso del paraovario: un tumor infrecuente

Appendectomy in retrograde order for complete removal of endometriosis

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