A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : CA-125 has been found to be high in almost all the patients with ascites. In this study, we tried to determine cut-off values of CA-125 in serum and ascitic fluid levels in order to discriminate non-ovarian malignancies, ovarian carcinomas and benign diseases. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 119 patients were included in the study. The patients were divided into three groups: non-ovarian malignancies, ovarian carcinoma and benign diseases. Serum and ascitic fluid CA-125 levels were measured by electrochemiluminescence immunoassay, 'ECLIA' method. In determining the discriminitive ability of CA-125 levels between the groups, receiver operating characteristic (ROC) analysis was performed. R Re es su ul lt ts s: : A total of 119 patients were included in the study: 55 males and 64 females. Of patients, 53 had non-ovarian malignancy, 19 had ovarian carcinoma and 47 had benign diseases. Serum and ascitic fluid CA-125 levels were high in all of the three groups. When cut-off value of ascitic CA-125 was taken as 174 U/mL, the sensitivity and specificity were found to be 69.2% and 25.5%, respectively; however, when the value was accepted as 796.5 U/mL, these rates were observed as 30.8% and 80.9% respectively. In the discrimination between ovarian carcinoma and benign diseases, when the cut-off value of ascitic CA-125 was considered as 411 U/mL, the sensitivity and specificity were obtained as 94.7% and 63.8% respectively. When the value was taken as 971.9 U/mL, the sensitivity and specificity rates were 57.9% and 78.7% respectively. C Co on nc cl lu us si io on n: : In discriminating between malign and benign ascites, ascitic CA-125 levels rather than serum values are of significance, and it can be suggested that malignancy should be persistently searched when the value is over 1000 U/mL. K Ke ey y W Wo or rd ds s: : CA-125 antigen; ascites Ö ÖZ ZE ET T A Am ma aç ç: : Asitli hastaların neredeyse tümünde CA-125 yüksekliği görülmektedir. CA-125 serum ve asit düzeylerinin over-dışı malign, over adenokarsinomu ve benign hastalıkları ayırmada cut-off değerlerini belirlemeye çalıştık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya toplam 119 asitli hasta dahil edildi. Hastalar over-dışı malign, over carsinomu ve benign hastalıklar şeklinde gruplandırıldı. Serum ve asit mayi CA-125 düzeyleri ölçüldü. CA-125 electrochemiluminescence immunoassay ''ECLIA'' metodu kullanılarak çalışıldı. CA-125 düzeyinin grupları birbirinden ayırt edebilme becerisini belirlemede "receiver operating characteristic (ROC)" analizi kullanıldı. B Bu ul lg gu ul la ar r: : Çalışmaya 64 bayan 55 erkek toplam 119 hasta dahil edildi. Elli üçü over-dışı malign, 19'u over adenokarsinomu ve 47'si benign hastalardı. Serum ve asit mayi CA-125 düzeyleri her üç grupta da yüksekti. Duyarlılık ve özgüllük over-dışı malign ve benign ayırımında asit CA-125 cut-off değeri 174.5 U/mL iken sırasıyla %69.2 ve %25.5; değer 796.5 U/mL iken sırasıyla %30.8 ve %...