Ovarian cAMP and cGMP fluctuations in the hamster during the oestrous cycle

Hubbard, Christopher

doi:10.1530/jrf.0.0590351

Cited by 23 publications

(14 citation statements)

References 14 publications

(17 reference statements)

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“…In the present study, cGMP accumulation was increased by eCG treatment but significantly decreased by the addition of hCG, consistent with previous reports [31]. Previous studies [32,33] have already shown a correlation between the changes in ovarian cGMP and steroid hormones during the hamster estrus cycle. The highest cGMP level, measured in the largest follicles, was observed at 0900 h at the day of proestrus when E 2 was already rising, reaching its peak at 1400 h. This observation is in agreement with our previous report showing that the level of CNP during proestrus was about 4-fold higher than the levels measured at any of the stages of the cycle.…”

Section: Discussionsupporting

confidence: 93%

Hormonal Regulation of Natriuretic Peptide System during Induced Ovarian Follicular Development in the Rat1

Gutkowska

Jankowski

Sairam

et al. 1999

Biology of Reproduction

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All components of the natriuretic peptide (NP) system have been found in the ovary. The purpose of this study was to determine the hormonal regulation of the NP system during follicular growth and ovulation induced by gonadotropins eCG and hCG. Ovarian membrane binding, before and after treatment, revealed the presence of guanylyl cyclase-type receptors exclusively. Equine CG treatment increased Bmax from 225 +/- 50 fmol/mg protein in control animals to 354 +/- 51 fmol/mg protein, and additional hCG treatment increased it further to 492 +/- 130 fmol/mg protein (p < 0.05), without changing receptor affinity. The increased binding was consistent with increased ability of atrial natriuretic peptide (ANP) to activate guanylyl cyclase in the ovarian cells obtained from hormone-treated animals. In confirmation, autoradiography of 125I-tyroCNP and 125I-ANP binding to the rat ovary showed that both guanylyl cyclase GC-A and GC-B receptor subtypes are localized to the granulosa cells of antral follicles. Quantitative analysis of GC-A and GC-B receptors by reverse transcription-polymerase chain reaction showed that the expression level of both receptors started to increase at 2 h and reached maximal levels at 6 h following eCG treatment. Increased levels of GC-B mRNA were also observed 12 h after eCG injection. At 24 and 48 h the receptor levels were below basal. Stimulation of NP receptors by eCG was paralleled by activation of both ovarian ANP and C-type natriuretic peptide (CNP) gene expression. ANP mRNA increased as early as 1 h after eCG injection and remained elevated up to 6 h. CNP mRNA increased at 2 h after eCG injection, peaked (5-fold) at 6 h, and remained elevated 48 h later, a stage at which follicular maturation continues. Incubation of ovaries with ANP significantly decreased eCG-induced estradiol level, indicating the functionality of the ovarian NP system. These results implicate the NP system in the induction and maintenance of fluid balance in the rapidly developing ovarian follicle.

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Section: Discussionsupporting

confidence: 93%

Hormonal Regulation of Natriuretic Peptide System during Induced Ovarian Follicular Development in the Rat1

Gutkowska

Jankowski

Sairam

et al. 1999

Biology of Reproduction

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“…The high activity of PDE4 in connection with high levels of cAMP suggests that PDE4 is involved in termination of the mid-cycle surge of gonadotropins, which causes a massive cAMP production in the GCs of preovulatory follicles (Hubbard, 1980). In fact, a PDE4 inhibitor in combination with a small dose of hCG has been used to induce ovulation in rats (McKenna et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Distribution and function of 3′,5′-Cyclic-AMP phosphodiesterases in the human ovary

Petersen

Kristensen

Jeppesen

et al. 2015

Molecular and Cellular Endocrinology

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“…As early as 1980, it is found that cGMP levels are highest at dioestrus but lowest during oestrus in hamster ovary [48], suggesting a functional relationship between cGMP levels and meiotic arrest. More and more studies indicate that cGMP is involved in the regulation of oocyte maturation.…”

Section: Cycle Gmpmentioning

confidence: 99%

Hormonal control of mammalian oocyte meiosis at diplotene stage

Zhang

Xia

2011

Cell. Mol. Life Sci.

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Mammalian oocytes grow and undergo meiosis within ovarian follicles. Fully grown oocytes are arrested at the first meiotic prophase by a mural granulosa origin "arrester" until a surge of luteinizing hormone (LH) from the pituitary at the mid-cycle stimulates the immature oocyte to resume meiosis. Recent evidence indicates that natriuretic peptide precursor type C (NPPC) produced by mural granulosa cells stimulates the generation of cyclic guanosine 3',5'-monophosphate (cGMP) by cumulus cell natriuretic peptide receptor 2 (NPR2), which diffuses into oocyte via gap junctions and inhibits oocyte phosphodiesterase 3A (PDE3A) activity and cyclic adenosine 3',5'-monophosphate (cAMP) hydrolysis and maintains meiotic arrest with a high intraoocyte cAMP level. This cAMP is generated through the activity of the Gs G-protein by the G-protein-coupled receptor, GPR3 and GPR12, and adenylyl cyclases (ADCY) endogenous to the oocyte. Further studies suggest that endocrine hormones, such as follicle-stimulating hormone (FSH), LH, 17β-estradiol (E2) and oocyte-derived paracrine factors (ODPFs), participate in oocyte meiosis possibly by the regulation of NPPC and/or NPR2. A detailed investigation of NPPC and NPR2 expression in follicle cells will elucidate the precise molecular mechanisms of gonadotropins, and control the arrest as well as resumption of meiosis.

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Ovarian cAMP and cGMP fluctuations in the hamster during the oestrous cycle

Cited by 23 publications

References 14 publications

Hormonal Regulation of Natriuretic Peptide System during Induced Ovarian Follicular Development in the Rat1

Hormonal Regulation of Natriuretic Peptide System during Induced Ovarian Follicular Development in the Rat1

Distribution and function of 3′,5′-Cyclic-AMP phosphodiesterases in the human ovary

Hormonal control of mammalian oocyte meiosis at diplotene stage

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