Ovalbumin content in the yellow fever vaccine

Smith, Douglas B.; Wong, Priscilla H.; Gomez, Robert; White, Kevin

doi:10.1016/j.jaip.2015.03.011

Cited by 17 publications

(24 citation statements)

References 6 publications

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“…One study measured the content of ovalbumin in the U.S. YFV, which was higher than the safest approved value in vaccinated patients with an egg allergy (50). However, three studies evaluated successful desensitization processes in eight patients with egg allergy, without AEs (49).…”

Section: Resultsmentioning

confidence: 99%

Yellow fever vaccine and risk of developing serious adverse events: a systematic review

Porudominsky¹,

Gotuzzo²

2018

Rev Panam Salud Publica

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Objective To evaluate contraindications and precautions for the yellow fever vaccine (YFV) in risk populations. Methods A literature review was conducted by searching PubMed for “yellow fever vaccine” and “adverse events” (AEs); 207 studies were found, and 43 of them met the inclusion criteria and were included in a systematic review. Results The results for first dose of YFV in elderly patients were conflicting—some showed AEs while some showed benefits. Therefore, precaution and case-by-case decisionmaking for YFV in this population are advised. The same precautions are warranted for YFV in infants 6-8 months, with the vaccine contraindicated in those < 6 months old and safe after 9 months of age. YFV seems safe in the first trimester of pregnancy, and probably throughout gestation, as it was not associated with increased malformations. During breastfeeding, YFV continues to be controversial. The vaccine seems safe in people being treated with immunomodulatory or immunosuppressive therapy, people with immunosuppressive diseases, and solid organ and hematopoietic stem cell transplant patients; in stem cell transplants, however, a booster dose should only be applied once immunity is recovered. HlV-infected patients with a CD4+ count > 200 cells/mm 3 do not have increased risk of AEs from YFV. Egg allergy vaccination protocols seem to provide a safe way to immunize these patients. Conclusions YFV safety has been confirmed based on data from many vaccination campaigns and multiple studies. AEs seem more frequent after a first-time dose, mainly in risk groups, but this review evaluated YFV in several of the same risk groups and the vaccine was found to be safe in most of them.

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Section: Resultsmentioning

confidence: 99%

Yellow fever vaccine and risk of developing serious adverse events: a systematic review

Porudominsky¹,

Gotuzzo²

2018

Rev Panam Salud Publica

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“…59 The YF vaccine Stamaril (UK) contains 0.13-0.61 ug/mL of egg protein, 60 and YF-VAX contains 2.43-4.42 ug/mL of egg protein, 59 used in USA. Compared to the recommendations for egg protein in TIV, egg protein in Stamaril is not high.…”

Section: Yellow Fever Vaccinementioning

confidence: 99%

Vaccination and allergy: EAACI position paper, practical aspects

Nilsson

Brockow

Alm

et al. 2017

Pediatric Allergy Immunology

128

184

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Immunization is highly effective in preventing infectious diseases and therefore an indispensable public health measure. Allergic patients deserve access to the same publicly recommended immunizations as non‐allergic patients unless risks associated with vaccination outweigh the gains. Whereas the number of reported possible allergic reactions to vaccines is high, confirmed vaccine‐triggered allergic reactions are rare. Anaphylaxis following vaccination is rare, affecting <1/100 000, but can occur in any patient. Some patient groups, notably those with a previous allergic reaction to a vaccine or its components, are at heightened risk of allergic reaction and require special precautions. Allergic reactions, however, may occur in patients without known risk factors and cannot be predicted by currently available tools. Unwarranted fear and uncertainty can result in incomplete vaccination coverage for children and adults with or without allergy. In addition to concerns about an allergic reaction to the vaccine itself, there is fear that routine childhood immunization may promote the development of allergic sensitization and disease. Thus, although there is no evidence that routine childhood immunization increases the risk of allergy development, such risks need to be discussed.

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“…If the test result is negative, vaccination can be given with a 60-min observation following the injection. If the skin test result is positive, the vaccine can be given in graded doses in a hospital [8].…”

Section: Hen’s Eggmentioning

confidence: 99%

“…On the other hand, 124 (14%) of 892 nonallergic children met the criteria for a possible allergic reaction to propofol [10]. Use of propofol in children with eosinophlic esophagitis was evaluated in 1365 upper intestinal tract endoscopy procedures by Mehta [8]. They found no differences in the rate of allergic reactions between food-allergic and nonallergic patients.…”

Section: Hen’s Eggmentioning

confidence: 99%

Hazardous Medications in Children with Egg, Red Meat, Gelatin, Fish, and Cow’s Milk Allergy

et al. 2019

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Childhood food allergies are a growing public health problem. Once the offending food allergens have been identified, a strict elimination diet is necessary in treatment or prevention of most of the allergic reactions. Accidental food ingestion can lead to severe anaphylaxis. Food- derived substances can be used in medications at various stages of the manufacturing process. In this review, the possible roles of medications which may contain egg, red meat, gelatin, and fish allergens on allergic reactions in children with food allergy were evaluated.

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Ovalbumin content in the yellow fever vaccine

Cited by 17 publications

References 6 publications

Yellow fever vaccine and risk of developing serious adverse events: a systematic review

Yellow fever vaccine and risk of developing serious adverse events: a systematic review

Vaccination and allergy: EAACI position paper, practical aspects

Hazardous Medications in Children with Egg, Red Meat, Gelatin, Fish, and Cow’s Milk Allergy

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