Ovalbumin content in 2009 to 2010 seasonal and H1N1 monovalent influenza vaccines

Safe vaccination of patients with egg allergy with an adjuvanted pandemic H1N1 vaccine

“…Although the reported ovalbumin content of 2009-2010 US Food and Drug Administrationapproved monovalent A/H1N1 vaccine was close (varying between 0.003 and 0.064 mg/mL) to that in our study, it was much higher in some trivalent seasonal influenza vaccines, reaching 1.08 to 1.42 mg/mL. 18 Further studies should assess the risk after administration of vaccines with ovalbumin content closer to the 1.2 mg/mL threshold described by James et al 9 None of the differences were significant.…”

Adverse reactions to vaccines practice parameter 2012 update

“…However, numerous studies have demonstrated that injectable influenza vaccine can be safely administered even to patients with severe egg allergy with appropriate precautions, 51-59 likely because of the very low amount of egg protein (ovalbumin) contained in recent years' vaccines. [60][61][62] Recommendations regarding the administration of influenza vaccine to recipients with egg allergy are specifically addressed in an addendum at the end of this practice parameter.…”

“…Three groups have separately analyzed the ovalbumin content from the United States-approved influenza vaccines for both H1N1 (2009-2010 season) and TIV (both 2009-2010 and 2010-2011 seasons). [60][61][62] Ovalbumin content ranged from 0.008 to 0.71 mg per 0.5 mL dose.…”

Statement on Seasonal Influenza Vaccine for 2011–2012

“…(87,88,90,92) Ovalbumin content in influenza vaccine manufactured in eggs may vary from year to year, between vaccine products or between lots of the same vaccine. (87,95,96) However, influenza vaccines marketed in Canada are approved under the European specification for ovalbumin content, which is currently <1.2 µg/mL, the level associated with low risks of adverse events. (89) After careful review, NACI concludes that egg-allergic individuals may be vaccinated against influenza using TIV, without a prior influenza vaccine skin test, based on an assessment of risk for a severe allergic reaction to guide the method of vaccination.…”