Safe vaccination of patients with egg allergy with an adjuvanted pandemic H1N1 vaccine

Gagnon, Rémi; Primeau, Marie Noel; Roches, Anne Des; Lemire, Chantal; Kagan, Rhoda; Carr, Stuart; Ouakki, Manale; Benoit, M; Serres, Gaston De

doi:10.1016/j.jaci.2010.05.037

Cited by 80 publications

(71 citation statements)

References 16 publications

(24 reference statements)

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“…In literature, studies have shown that children with egg allergy are vaccinated in a single dose, in 2 divided doses, or with a graded dose increase (19 (23,24). Among those administered divided vaccination at equal doses, we found doubtful rashes in one patient who underwent only measles vaccination in our clinic, but we did not have any systemic findings.…”

Section: Discussionmentioning

confidence: 99%

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Özdemir¹,

Ersavas²

2017

JAREM

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Objective: Egg allergy is the second most common food allergy in infants and may cause urticaria, angioedema, anaphylaxis, and exacerbation of atopic dermatitis. Egg allergy is diagnosed by carefully examining a patient's clinical history, performing contributory skin prick tests, and assessing specific IgE levels to hen's egg. The administration of measles, measles-mumps-rubella (MMR), and varicella vaccinations to children with egg allergy remains controversial. These vaccines contain trace amounts of egg proteins as they are produced in chicken embryo fibroblast cultures. The incidence of anaphylaxis as a result of vaccinations is very low, and its cause (egg or gelatin) is not well known. Here we report our experience with the three vaccinations in 18 patients with egg allergy (34 dose).Methods: Between 2013 and 2016, we retrospectively evaluated patients with egg allergy who presented to our allergy clinic for vaccinations. After performing the skin prick test for patients who were admitted to our clinic, vaccinations were administered by dividing the doses in equal two parts.Results: All patients had a clinical history, and atopic dermatitis coexisted with egg allergy in three patients. The skin prick test results were positive in 12 (67%) patients. The specific IgE test was positive in 16 (89%) patients. There was a reaction in just one (2.9%) patient of 18 patients of 34 dose vaccinations.Conclusion: Measles, MMR, and varicella vaccinations in children with egg allergy were found to be safe albeit small number of patients. We believe that egg allergy does not necessitate a delay or contraindication for vaccination.

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Section: Discussionmentioning

confidence: 99%

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Özdemir¹,

Ersavas²

2017

JAREM

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“…[4] Up to 4% of recipients have mild systemic reactions with either method. People with egg allergy may be vaccinated against influenza routinely; [4][5][6][7] however, the lowest ovalbumincontaining vaccine is recommended.…”

Section: Influenzamentioning

confidence: 99%

Vaccination in food allergic patients

Karabus

Gray²,

Goddard

et al. 2014

S Afr Med J

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“…Safety checking about allergic reactions is mainly centered on minor protein components included in adjuvanted vaccines that possibly trigger an anaphylactic response. 10 Presumptive allergy following a vaccination episode often accounts on diagnostic tests that might not solve the diagnostic suspect; in addition a delayed-hypersensitivity reaction may occur. So, besides to inform physicians and pediatricians as well as parents about possible severe complications after the administration of vaccines, extensive studies are requested in order to assess or exclude a relation between vaccination and serious impairments, mainly in infants.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Use of basophil activation test in the investigation of adverse effects to vaccines

Chirumbolo

2011

Human Vaccines

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Safe vaccination of patients with egg allergy with an adjuvanted pandemic H1N1 vaccine

Cited by 80 publications

References 16 publications

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Vaccination in food allergic patients

Use of basophil activation test in the investigation of adverse effects to vaccines

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