Outpatient treatment of Hickman catheter infections

Pye, K.; Kelsey, Steve; Newland, Adrian C.

doi:10.1016/0140-6736(92)91183-9

Cited by 9 publications

(1 citation statement)

References 7 publications

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“…A minimum of 5 to 7 days of parenteral antibiotic therapy after resolution of fever is recommended [ 13, 151. Retrospective studies and prospective clinical trials have proved that a certain fraction of FN patients fall in the "low-risk" category in which hospitalization is not strictly indicated [16]. Such patients have been managed with various antimicrobial protocols, such as monotherapy, home therapy, and oral antibiotics [l, 17,181. Hospitalized patients at low risk can be discharged early with oral antibiotics even before the recovery of neutropenia [19][20][21][22].…”

Section: Disc Ussl Onmentioning

confidence: 99%

Outpatient Antimicrobial Protocol for Febrile Neutropenia: A Nonrandomized Prospective Trial Using Ceftriaxone, Amikacin, and Oral Adjuvant Agents

Sahu

Bapna

Pai

et al. 1997

Pediatric Hematology and Oncology

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Broad-spectrum antimicrobial therapy has revolutionized the management of febrile neutropenia (FN) in cancer patients. In vogue is an effective therapy an an outpatient basis. One thousand three hundred episodes of FN observed in 70 pediatric solid tumors (STs) and 65 cases of hematomalignancy (HM) at a median age of 5.5 years were treated with a protocol using once-a-day injectable ceftriaxone plus amikacin and other oral adjuvant antimicrobial agents. The mean duration of FN in the ST group was 4.0 +/- 1.2 days and in the HM group was 5.0 +/- 2.5 days. The mean duration of antimicrobial cover in the ST group was 5.0 +/- 1.75 days and in the HM group was 6.0 +/- 1.5 days. The overall recrudescence rate was 6% and the mean duration to recrudescence was 4 +/- 1.5 days (range 3-6 days). The objectives of this protocol were cost reduction and utilization of the available inpatient resources optimally by reducing the pressures of hospitalization for febrile neutropenia. We concluded that a selected group of patients with FN can be effectively managed with this regimen on an outpatient basis.

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