Outpatient pipelle endometrial biopsy in the investigation of postmenopausal bleeding

Batool, Tahira; Reginald, P. W.; Hughes, John

doi:10.1111/j.1471-0528.1994.tb13161.x

Cited by 54 publications

(47 citation statements)

References 6 publications

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“…9,25,34,38 -45 Seven studies were limited to postmenopausal women. 9,13,14,21,24,26,41 All other studies either reported on both premenopausal and postmenopausal women or did not report on the menopausal status of the included patients. One study reported on asymptomatic women only, 38 and 14 studies reported on symptomatic women only.…”

Section: Resultsmentioning

confidence: 99%

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

Dijkhuizen

Mol²,

Brölmann³

et al. 2000

Cancer

117

134

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Section: Resultsmentioning

confidence: 99%

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

Dijkhuizen

Mol²,

Brölmann³

et al. 2000

Cancer

117

134

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“…A further 13 articles 50 -62 were identified through examination of the reference lists of the known primary publications and review articles. After independent review of the 52 manuscripts, 11 articles (10 English 16,36,38,39,43,46,50,52,57,62 , one French 35 ) were considered to be eligible for inclusion in the review (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…The assessment of outcome data shows that in only two (18%) of the studies were the outpatient test results reported to be masked from the pathologist interpreting the reference standard. Thus two studies 36,46 (18%) were level I, a further two studies 35,43 (18%) were level III and seven studies 16,38,39,50,52,57,62 (64%) were level IV in quality.…”

Section: Study Qualitymentioning

confidence: 99%

Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review

Clark

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To determine the accuracy of outpatient endometrial biopsy in diagnosing endometrial cancer in women with abnormal uterine bleeding.Design A systematic quantitative review of published research.Methods Studies were selected if accuracy of outpatient endometrial biopsy was estimated compared with a reference standard. Diagnostic accuracy was determined by pooled likelihood ratios for positive and negative test results. There were 1013 subjects in 13 diagnostic evaluations reported in 11 primary studies.Results A positive test result on outpatient biopsy diagnosed endometrial cancer with a pooled likelihood ratio of 66.48 (95% CI 30.04 -147.13) while a negative test result had a pooled likelihood ratio of 0.14 (95% CI 0.08 -0.27). The post test probability of endometrial cancer was 81.7% (95% CI 59.7% -92.9%) for a positive test and 0.9% (95% CI 0.4% -2.4%) for a negative test.Conclusion Outpatient endometrial biopsy has a high overall accuracy in diagnosing endometrial cancer when an adequate specimen is obtained. A positive test result is more accurate for ruling in disease than a negative test result is for ruling it out. Therefore, in cases of abnormal uterine bleeding where symptoms persist despite negative biopsy, further evaluation will be warranted.

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“…These findings replicate other published studies which have demonstrated that age and menopausal status may be factors of importance for sample adequacy. 67,68 In the moderate-risk (premenopausal) women for whom insertion was possible, nulliparity was for both Tao brush and Pipelle samplers an important factor in the outcome 'inadequate sample' (p < 0.001 for both), in addition to its effect on insertion. These findings suggest that the use of Tao brush may be advantageous in the investigation of postmenopausal women, but not for moderate-risk women.…”

Section: Performance Of Investigative Modalitymentioning

confidence: 99%

“…This reflects the rates reported in other clinical trials. 18,67 The present study also considered individual characteristics that may influence the performance of the two endometrial sampling methods. Nulliparity was strongly associated with failure of insertion, whereas for parous women, the vast majority, the failure rate was only 8%.…”

Section: Performance Of Investigative Modalitymentioning

confidence: 99%

Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures within cohorts defined by age and menopausal status

Critchley

Warner²,

Lee³

et al. 2004

Health Technol Assess

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Outpatient pipelle endometrial biopsy in the investigation of postmenopausal bleeding

Cited by 54 publications

References 6 publications

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review

Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures within cohorts defined by age and menopausal status

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