Outer submucous plexus: An intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans

Timmermans, Jean‐Pierre; Hens, J. Martínez; Adriaensen, Dirk

doi:10.1002/1097-0185(20010101)262:1<71::aid-ar1012>3.0.co;2-a

Cited by 112 publications

(105 citation statements)

References 67 publications

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“…In large mammals, like pigs and humans, submucosal ganglia are interconnected and distributed in two or three levels (Schabadasch;Gunn, 1968;Timmermans et al), and the ganglia at different depths have distinct neuronal populations. In small rodents, the submucosal plexus is unique, probably due to the thickness of the submucosal tela (Gunn;Furness & Costa;Brehmer et al, 2010).…”

Section: Introductionsupporting

confidence: 80%

“…These animals were not considered experimental models, therefore, their study was based on the interest in the filogenetic description. Despite the similarity among mammals, it is suggested that the arrangement of the submucosal neurons are species specific (Hoyle & Burnstock, 1989;Timmermans et 2001) and their description in rodents broadens the possibility of studies on experimental models.…”

Section: Introductionmentioning

confidence: 99%

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Morphoquantitative Study of Rattus norvegicus Submucosal Plexus by Different Neuronal Evidentiation Histochemical Techniques

et al. 2016

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SUMMARY:Enteric nervous plexuses have been the object of several studies, specially the myenteric plexus whose studies describe its organization, functions and alterations. On the other hand, the submucosal plexus has been less studied and still needs descriptive studies. To analyze morphologically and quantitatively submucosal neurons of the jejunum of 90-day-old healthy rats using different techniques for neuronal staining as a way to provide normality data to compare with future experimental studies. Whole mount preparations of the jejunum were submitted to Giemsa, NADH-diaphorase and NADPH-diaphorase techniques to stain the total neuronal population, more metabolically active subpopulation and subpopulation of nitrergic neurons, respectively. Neurons of the submucosal plexus of adult rats are mainly organized in ganglia with varied sized and shapes. Giemsa technique stained 243.93 ± 7.68 neurons per mm 2 . Regarding the total population stained by Giemsa, NADH-diaphorase positive (139.09 ± 11.14/mm 2 ) neurons represented 57 % and NADPH-diaphorase positive (18.17 ± 0.28/mm 2 ) represented 7.5 %. The area of the cell body was bigger in nitrergic neurons (412.29 ± 150.22) than in the ones stained by Giemsa (254.71 ± 63.32) and NADH-diaphorase positive (243.98 ± 123.82).

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Section: Introductionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Morphoquantitative Study of Rattus norvegicus Submucosal Plexus by Different Neuronal Evidentiation Histochemical Techniques

et al. 2016

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“…In larger species (e.g., pigs and humans) the submucosal plexus contains more neuron types, is more complex, and is directly involved in control of both secretion and motility (Timmermans et al, 2001). Therefore, although the functional types of neuron that occur in the submucosal ganglia of the guinea-pig small intestine likely to occur in larger mammals, there are other neuron types present, and it is not possible to extrapolate the relationships between morphology and function, as determined in the present work, to other species.…”

Section: Comparisons With Other Speciesmentioning

confidence: 99%

Morphologies and projections of defined classes of neurons in the submucosa of the guinea‐pig small intestine

et al. 2003

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Four types of neurons have previously been identified by neurochemical markers in the submucosal ganglia of the guinea-pig small intestine, and functional roles have been ascribed to each type. However, morphological differences among the classes have not been determined, and there is only partial information about their projections within the submucosa. In the present work, we used intracellular microelectrodes to fill neurons of each type with biocytin, which was then converted to a permanent dye, so that the shapes of the neurons could be determined and their projections within the submucosa could be followed. Cell bodies of noncholinergic secretomotor/ vasodilator neurons had Dogiel type I morphology. These neurons, which are vasoactive intestinal peptide immunoreactive, had single axons that ran through many ganglia without providing terminals around other neurons. Cholinergic secretomotor neurons with neuropeptide Y immunoreactivity had Stach type IV morphology, and cholinergic secretomotor/vasodilator neurons had stellate cell bodies. The axons of these two types ran short distances in the plexus and did not innervate other submucosal neurons. Neurons of the fourth type, intrinsic primary afferent neurons, had cell bodies with Dogiel type II morphology and their processes supplied networks of varicose processes around other nerve cells. It is concluded that each functionally defined type of submucosal neuron has a characteristic morphology and that intrinsic primary afferent neurons synapse with secretomotor neurons to form monosynaptic secretomotor reflex circuits. Anat Rec Part A 272A: 475-483, 2003.

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“…The inner submucosal plexus is adjacent to the muscular lamina of the mucous membrane. The outer submucosal plexus is located in the submucous tissue adjacent to the circular layer of the muscular membrane of the intestine [1,6,7]. In humans, there is an additional plexus known as the intermediate submucosal plexus (IMSP) [3,4,6,8].…”

Section: Introductionmentioning

confidence: 99%

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.

Godlewski

2010

Folia Histochem Cytobiol.

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Abstract:The innervations of the large intestine is responsible for it peristalsis and contractilibility. Investigations of the enteric nervous system in many colon diseases have revealed changes in this structure. No study has been carried out on morphological changes of the enteric nervous system in the human large intestine with carcinoma. The aim of this study was to investigate potential changes in the structure of the enteric neurons in patients with sigmoid and rectal cancer. Material for the study was obtained from patients undergoing operations due to carcinoma of the sigmoid colon and rectum. Microscopic observation of the cancerous tumor of the human large intestine revealed changes in the enteric nervous system innervating this part of the gastrointestinal tract. In the region of the enteric plexuses located close to the tumour, disruption of their correct placement and structure was observed. The changes also consisted of the disappearance of neurons and nerve fibers forming these plexuses. In the solid cancerous tumour, elements of the enteric nervous system were not present. Destruction of the enteric nervous system in the course of carcinoma of the large intestine may cause disruption of proper intestinal function and may be responsible for part of symptoms which the patients suffer.

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Outer submucous plexus: An intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans

Cited by 112 publications

References 67 publications

Morphoquantitative Study of Rattus norvegicus Submucosal Plexus by Different Neuronal Evidentiation Histochemical Techniques

Morphoquantitative Study of Rattus norvegicus Submucosal Plexus by Different Neuronal Evidentiation Histochemical Techniques

Morphologies and projections of defined classes of neurons in the submucosa of the guinea‐pig small intestine

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.

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