2021
DOI: 10.1167/tvst.10.10.15
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Outer Retinal Cell Replacement: Putting the Pieces Together

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Cited by 23 publications
(23 citation statements)
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References 248 publications
(371 reference statements)
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“…Transplantation of PSC-derived RPE cells for the treatment of AMD and Stargardt’s macular dystrophy has now moved into clinical trials ( Wang et al., 2020 ). In contrast, progress with photoreceptor replacement still faces a number of challenges, including optimizing uniform delivery of a large number of donor cells, improving long-term survival of donor photoreceptors, promoting sufficient integration into the host retina, and establishing functional synaptogenesis to enable recovery of visual function ( Ludwig and Gamm, 2021 ). In addition, the avoidance of immune rejection of allogeneic transplants needs further optimization before clinical trials can be initiated ( Zhang et al., 2021 ).…”
Section: Discussionmentioning
confidence: 99%
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“…Transplantation of PSC-derived RPE cells for the treatment of AMD and Stargardt’s macular dystrophy has now moved into clinical trials ( Wang et al., 2020 ). In contrast, progress with photoreceptor replacement still faces a number of challenges, including optimizing uniform delivery of a large number of donor cells, improving long-term survival of donor photoreceptors, promoting sufficient integration into the host retina, and establishing functional synaptogenesis to enable recovery of visual function ( Ludwig and Gamm, 2021 ). In addition, the avoidance of immune rejection of allogeneic transplants needs further optimization before clinical trials can be initiated ( Zhang et al., 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…Human embryonic stem cells (hESCs) or induced pluripotent stem cell (iPSC)-derived photoreceptor precursor cells (PRPCs) that develop into retinal organoids (ROs) are a promising source for regenerative experimental therapies to restore photoreceptor function ( Ludwig and Gamm, 2021 ). Cell replacement studies in rodents have shown restoration of visual function using either ESC- or iPSC-PRPCs ( Ribeiro et al., 2021 ; Tu et al., 2019 ), and several clinical trials in humans are exploring the use of allogenic and autologous cell therapies for photoreceptor replacement ( Wang et al., 2020 ).…”
Section: Introductionmentioning
confidence: 99%
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“…Regenerative medicine offers the exciting promise to restore vision through cell replacement therapy, where stem and progenitor-like cells (SCs) are transplanted into the retinal host to replace damaged and/or degenerated neurons (reviewed in [ 13 , 14 , 15 , 16 ]). A classical model of functional integration relies upon transplanted cells to perform several complex behaviors [ 17 , 18 , 19 ] including: (i) surviving surgical insertion into a damaged, adult host [ 20 ]; (ii) Infiltrating endogenous neural networks to achieve desired cellular positioning [ 21 , 22 ]; (iii) Differentiating appropriately into targeted neuronal cell type(s) [ 23 ]; and (iv) Initiating new synapses with functional, native cells to re-establish vision [ 24 , 25 , 26 ].…”
Section: Introductionmentioning
confidence: 99%