Outcomes of Primary Squamous Cell Carcinoma of Major Salivary Glands Treated by Surgery With or Without Postoperative Radiotherapy

Wang, Lina; Li, Hao; Yang, Zhongyuan; Chen, Wenkuan; Zhang, Quan

doi:10.1016/j.joms.2015.03.016

Cited by 18 publications

(25 citation statements)

References 16 publications

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“…Parotid cancers account for 70% of all salivary gland malignancies, and there are 24 different types of malignancies [1–3], of which squamous cell carcinoma (SCC) is one of the least common histologic subtypes. SCC usually conveys a poor 5-year survival rate of less than 50% with an incidence varying from 0.1 to 10% in salivary malignancies [4–10].…”

Section: Introductionmentioning

confidence: 99%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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s Background Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment. The goal of the current study was to analyse the potential prognostic factors and clinical outcomes for this tumour type. Methods Consecutive patients with surgically treated primary parotid SCC were retrospectively enrolled in this study. The primary end point was locoregional control (LRC) and disease-specific survival (DSS), which were calculated by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method. Results In total, 53 patients were included for analysis. Perineural and lymphovascular invasion were observed in 21 and 16 patients, respectively. Intraparotid node (IPN) metastasis was reported in 23 patients with an incidence rate of 43.3%. Twenty-six patients with cN0 disease underwent neck dissection, and pathologic node metastasis was observed in 10 cases. The 5-year LRC and DS S rates were 35 and 49%, respectively. The Cox model was used to report the independence of disease stage and IPN metastasis in predicting LRC and the independence of disease stage and perineural invasion in predicting DSS. Conclusions The prognosis of primary parotid SCC is relatively unfavourable. IPN metastasis significantly decreases disease control, disease stage is the most important prognostic factor, and neck dissection is suggested for patients at any stage.

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Section: Introductionmentioning

confidence: 99%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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“…However, for squamous cell malignancies in particular, the data is sparser. A single‐institution review by Wang et al of 34 cases found a trend toward improved disease‐free survival for those treated with adjuvant radiotherapy, whereas an earlier study from our group of prognostic factors for salivary malignancies found that treatment with surgery and adjuvant radiotherapy was associated with improved survival compared to treatment with radiotherapy alone but not when compared to treatment with surgery alone . Given the sequelae of radiotherapy, it is important to demonstrate its role in improving patient prognosis in order to provide a rationale for its use .…”

Section: Introductionmentioning

confidence: 95%

Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma

et al. 2018

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“…In 1 recent study, the exclusion criteria included a history of SCC in any other site of the head and neck, a history of other malignancies of the salivary glands, SCC confined to intraglandular lymph nodes, subsequent identification of a primary SCC tumor of the head and neck, and treatment by nonoperative procedures. 53 The identification of a carcinoma that is confined to the intraglandular lymph nodes is good morphologic evidence of metastatic SCC. Emerging studies on the genetic alterations of metastatic SCCs may shed some light on this challenging dilemma in the near future.…”

Section: Accuracy Of Fnab and Differential Diagnosis Of Smsgmentioning

confidence: 99%

FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

Wang

Hoda

Faquin

et al. 2016

Cancer Cytopathology

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Outcomes of Primary Squamous Cell Carcinoma of Major Salivary Glands Treated by Surgery With or Without Postoperative Radiotherapy

Cited by 18 publications

References 16 publications

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma

FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

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