FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

Wang, He; Hoda, Raza S; Faquin, William C.; Rossi, Esther Diana; Hotchandani, Nihar; Sun, Tsieh; Pusztaszeri, Marc; Bizzarro, Tommaso; Bongiovanni, Massimo; Patel, Viren; Jhala, Nirag; Fadda, Guido; Gong, Yun

doi:10.1002/cncy.21798

Cited by 33 publications

(55 citation statements)

References 56 publications

(98 reference statements)

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“…Lesions range from well‐ to poorly‐differentiated. Roughly 1 in 6 cases of metastatic SCC will demonstrate significant keratinization, a finding rare in other lesions on the differential . More high grade lesions will demonstrate greater atypia, and 5% of lesions show necrosis …”

Section: Malignant Neoplasmsmentioning

confidence: 99%

“…Roughly 5 to 10% of tumors of the major salivary glands represent secondary malignancies, with squamous‐cell carcinoma (SCC) being one of the more common entities to involve them, either through metastasis or contiguous extension from a mucosal lesion . The parotid gland represents the most common salivary gland involved due to the presence of numerous intraparotid lymph nodes.…”

Section: Malignant Neoplasmsmentioning

confidence: 99%

“…Cutaneous SCCs located within the region of the ear, cheek, or temple are particularly at risk of metastasizing to parotid lymph node when their thickness exceeds 4 mm . Patients are usually elderly, with a mean age in the early 70s . The M : F ratio is roughly 2:1 …”

Section: Malignant Neoplasmsmentioning

confidence: 99%

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The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Oncocytic lesions of the salivary gland include oncocytosis, oncocytoma, and oncocytic carcinoma. In addition to the true oncocytic lesion, there exists another group of salivary gland lesions, which demonstrate cells with abundant and occasionally granular cytoplasm. These are often termed as “oncocytoid” lesions. The recently proposed Milan System for reporting salivary gland cytology clearly states that fine‐needle aspiration specimens representing oncocytic/oncocytoid lesions of salivary gland cannot effectively distinguish between a nonneoplastic lesion, benign and malignant neoplasms. Therefore, most lesions lacking classic cytomorphologic features will be classified under the umbrella diagnostic term of “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP). In this review, we discuss and illustrate key clinicopathologic and radiologic features that can help the practicing cytopathologist narrow down the differential and provide the best management based diagnosis.

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Section: Malignant Neoplasmsmentioning

confidence: 99%

Section: Malignant Neoplasmsmentioning

confidence: 99%

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The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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“…However, the presence of the triad of epidermoid, mucinous and intermediate cells in a background of mucin favors MEC over other neoplasms of the salivary gland with oncocytic features. Metastatic breast carcinoma to the salivary gland has been reported in literature . Metastatic breast carcinoma with, apocrine features in particular (Figure A‐F), can be exceptionally challenging to differentiate from intra‐ductal carcinoma, since both the mammary and salivary duct neoplasms with apocrine features share striking morphological similarities and immunohistochemical staining patterns.…”

Section: Discussionmentioning

confidence: 99%

Cytopathology approach to rare salivary gland lesions with oncocytic features

Hussein

Khader

2019

Diagnostic Cytopathology

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Salivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. Fine needle aspiration is usually the initial approach in the management of these lesions, whether they represent neoplastic or non‐neoplastic processes. Owing to the limited material present upon cytopathologic examination, knowledge of variants and subtypes of various oncocytic lesions that can occur in this area is of major importance to provide the most accurate interpretation to the patients and clinicians. In this article, we selected rare lesions of the salivary glands that may exhibit oncocytic changes, and provided a brief discussion of each one of them, with emphasis on challenges in navigating the differential diagnosis that these cases may pose, from the cytopathology standpoint.

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“…It makes sense that a reliable tool in the evaluation of lymph nodes is represented by ultrasound combined with fine‐needle aspiration cytology (FNAC). This technique has demonstrated interesting results in terms of diagnostic accuracy in head and neck cancer, thyroid neoplasms, and breast, lung, and cervical carcinoma …”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

Angelico

Santoro

Inzani

et al. 2019

Cancer Cytopathology

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Background Lymph node metastases represent the most important negative prognostic predictor in vulvar carcinoma. Therefore, an accurate preoperative assessment of suspicious lymph nodes would be fundamental for a personalized therapy. The aim of this article was to assess the reliability of ultrasound‐guided fine‐needle aspiration cytology (FNAC) in the preoperative assessment of nodal metastatic disease in 43 patients with vulvar cancer. Methods In total, 43 FNAC specimens of clinicoradiologically suspicious lymph nodes with corresponding nodal resection specimens were collected from 2016 to 2018 at Catholic University Hospital in Rome. Cytohistologic correlation was performed. Patients were treated with wide local excision of the vulvar mass followed by bilateral inguinofemoral lymphadenectomy and radiotherapy if the tumor involved a lymph node or the vulvar margins. Results Cytologic examination agreed with histology in 37 of 43 cases (86.04%). The authors observed a positive FNAC result in 14 of 20 histologically confirmed metastatic lymph nodes, 6 false‐negative cases, and no false‐positive results. The sensitivity and specificity of cytological examination were 76.92% and 100%, respectively. All patients with FNAC‐positive results showed metastatic disease in other surgically resected inguinofemoral nodes. Eleven of 29 patients (37.9%) with FNAC‐negative results also showed metastatic disease in subsequent lymphadenectomy specimens, but the extent of metastases was always <1 cm (range, 0.1‐0.6 cm). Conclusions FNAC of suspicious lymph nodes represents a useful tool in the management of patients with vulvar cancer. A positive result enables the surgeon to immediately perform a bilateral inguinofemoral lymphadenectomy thus avoiding an unnecessary sentinel lymph node sampling. Finally, FNAC can also predict the presence and extent of metastatic disease in other surgically resected inguinofemoral lymph nodes.

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FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases

Cited by 33 publications

References 56 publications

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Cytopathology approach to rare salivary gland lesions with oncocytic features

Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

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