Outcomes of patients with adenoid cystic carcinoma of the minor salivary glands

DeAngelis, A.; Tsui, Alpha; Wiesenfeld, D.; Chandu, Arun

doi:10.1016/j.ijom.2011.02.010

Cited by 57 publications

(71 citation statements)

References 28 publications

(111 reference statements)

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“…ACC is a disease with long evolution, featuring recurrence, not so much locally as by remote metastasis. The literature reports 55-90% 5-year and 30-70% 10-year overall survival [15], and accordingly, our results showed how overall survival continues to drop after the 5-year follow up period, producing considerably lower 10-year survival rate (Fig. 1d) in accordance with literature results [16,17].…”

Section: Discussionsupporting

confidence: 93%

Parotid adenoid cystic carcinoma: Retrospective single institute analysis

Mannelli

Cecconi

Fasolati

et al. 2017

American Journal of Otolaryngology

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a b s t r a c t a r t i c l e i n f oArticle history: Received 10 February 2017 Available online xxxx Purpose: Adenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome. Materials and methods: We retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treated at our Institution. Forty-four ACC were included in this study. Multivariate analysis risk models were built to predict recurrence free probability (RFP), distant recurrence free probability (DRFP), overall survival (OS) and disease free survival (DFS). Results: Twenty-one patients (47.7%) died from ACC and 2.3% for other causes. The 41% presented local-regional recurrence, with a regional-RFP rate of 93%, and the 34% reported distant metastases (DM). The five and ten-year OS rates were 74% and 50%, respectively. Conclusions: Recurrences were mainly influenced by the presence of perineural invasion and nerve paralysis, whilst female gender and age b 50 were predictors for good prognosis.

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Section: Discussionsupporting

confidence: 93%

Parotid adenoid cystic carcinoma: Retrospective single institute analysis

Mannelli

Cecconi

Fasolati

et al. 2017

American Journal of Otolaryngology

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“…17,18 Among the studies that evaluated histopathological types, the most frequent was the cribriform pattern, followed by tubular and solid patterns. 3,9,11,13,15 In the study by Khan et al,14 there was a predominance of the solid pattern, whereas in the study by Bianchi et al, 12 the number of affected cases showing the cribriform and solid patterns were similar.…”

Section: Discussionmentioning

confidence: 92%

“…3,7,9---15 Among the selected studies, three were carried out in developing countries 9,11,13 and six in developed ones. 3,7,10,12,14,15 Article methods and results are shown in Tables 1 and 2. Regarding the study profiles, sample size ranged from 21 11 to 616 9 patients, with the total sample size being 1185 patients with a mean age >50 years. The selected studies were published between the years 2001 and 2013.…”

Section: Resultsmentioning

confidence: 99%

“…18 In the study by Khan et al, 14 29 patients had local recurrence and the author associated the presence of perineural invasion with increased recurrence rates, as well as a higher incidence of positive margins, which is consistent with the other selected studies. 3,7,9,11 A study conducted in 1997 found a decrease in recurrence rates over the years due to the effects of radiotherapy use, but with no significant impact on distant metastasis rates. 17 Pain and discomfort complaints are not unusual and are often attributed to tumor invasive behavior.…”

Section: Discussionmentioning

confidence: 99%

“…2 The ACC is a malignant neoplasm that, in spite of its slow growth, has a poor prognosis due to aggressive tumor invasion and a high rate of recurrence. 3 This neoplasm was first described by Billroth in 1856. 4 It can develop in several anatomical sites, such as the major and minor salivary glands, lacrimal glands, and upper aerodigestive tract glands.…”

Section: Neoplasias Das Glândulas Salivares; Glândulas Salivares; Neomentioning

confidence: 97%

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Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review

Dantas

Morais

Macedo

et al. 2015

Brazilian Journal of Otorhinolaryngology

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Prognosis and risk factors for early‐stage adenoid cystic carcinoma of the major salivary glands

Bhayani

Yener

El‐Naggar

et al. 2011

Cancer

116

108

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BACKGROUND: Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and distant metastasis (DM). However, these findings frequently are reported in patients with advancedstage tumors, but the outcomes of early-stage tumors are poorly defined. We sought to evaluate the risk factors for the development of DM in early-stage ACC. METHODS: We retrospectively reviewed the charts of 60 patients who were diagnosed with clinical early-stage (T1-2/N0) ACC to determine the risk factors for development of DM and survival of these patients. RESULTS: DM was detected in 12 (20%) of the patients, with a median latency of 31.5 months after diagnosis. Univariate analysis revealed that DM was associated with age !45 years, pathologically positive lymph nodes, extracapsular spread (ECS) from lymph nodes, high-grade histology, and solid tumor subtype. Multivariate analysis revealed solid tumor subtype and ECS to be significantly associated with DM. Disease-specific survival rates at 5 and 10 years for patients with DM were 80% and 40%, respectively, and were both 100% for patients without DM. CONCLUSION: Although the majority of patients with clinical early-stage ACC of the major salivary glands have favorable prognosis, a significant percentage of patients will develop DM. Solid tumor subtype and nodal ECS were independent predictors of DM in early-stage ACC of major salivary glands. Other clinical and pathological variables may also contribute. These subgroups had poor overall and disease-specific survival. Such patients should be observed closely for the development of DM. Systemic therapy should be considered at the time of diagnosis.

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Outcomes of patients with adenoid cystic carcinoma of the minor salivary glands

Cited by 57 publications

References 28 publications

Parotid adenoid cystic carcinoma: Retrospective single institute analysis

Parotid adenoid cystic carcinoma: Retrospective single institute analysis

Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review

Prognosis and risk factors for early‐stage adenoid cystic carcinoma of the major salivary glands

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