Outcomes of Long-Term Noninvasive Ventilation Use in Children with Neuromuscular Disease: Systematic Review and Meta-Analysis

Al-Balawi, Mohammed M.; Castro‐Codesal, Maria L.; Featherstone, Robin; Sebastianski, Meghan; Vandermeer, Ben; Alkhaledi, Bashar; Bedi, Prabhjot K.; Abusido, Tamer; MacLean, Joanna E.

doi:10.1513/annalsats.202009-1089oc

Cited by 15 publications

(11 citation statements)

References 55 publications

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“…Bilevel using a nasal mask can be used to successfully treat SDB associated with neuromuscular diseases 271 . A recent systematic review and meta-analysis found that sleep parameters improve with the long-term use of Bilevel in this population 272 .…”

Section: Sleep Breathing Disorders In Pediatricsmentioning

confidence: 89%

Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines

Frange¹,

Franco²,

Brasil³

et al. 2022

Sleep Sci

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This clinical guideline supported by the Brazilian Sleep Association comprises a brief history of the development of Brazilian sleep physiotherapy, outlines the role of the physiotherapist as part of a sleep health team, and describes the clinical guidelines in respect of the management of some sleep disorders by the physiotherapist (including sleep breathing disorders, i.e., obstructive sleep apnea, central sleep apnea, upper airway resistance syndrome, hypoventilation syndromes and overlap syndrome, and pediatric sleep breathing disorders; sleep bruxism; circadian rhythms disturbances; insomnia; and Willis-Ekbom disease/periodic limb movement disorder. This clinical practice guideline reflects the state of the art at the time of publication and will be reviewed and updated as new information becomes available.

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Section: Sleep Breathing Disorders In Pediatricsmentioning

confidence: 89%

Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines

Frange¹,

Franco²,

Brasil³

et al. 2022

Sleep Sci

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show abstract

“…19,20 Sleepdisordered breathing is associated with RRTIs in children with SMA, and long-term noninvasive ventilation can improve PSG scores and reduce the incidence of respiratory tract infection. 21 Our study used SMA children as samples and analyzed the association between PSG scores and the occurrence of RRTIs and ARF, which ensured the objectivity of the results and applicability to SMA disease. Our study showed that AHI > 10.2 events/h and MSpO 2 < 95.5% suggested a high risk for RRTIs and/or ARF in children with SMA.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for recurrent respiratory tract infections or acute respiratory failure in children with spinal muscular atrophy

Guo

Meng

Cao

2022

Preprint

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Introduction: Assessment of and intervention for sleep-disordered breathing and malnutrition are related to respiratory management for preventing recurrent respiratory tract infections (RRTIs) and acute respiratory failure (ARF) in children with spinal muscular atrophy (SMA). However, the specific standard has not been clarified. Purpose: The study aimed to obtain the risk factors and the predictive index for RRTIs and/or ARF in children with SMA. Methods: In this retrospective study, the differences in clinical characteristics in patients with or without RRTIs and ARF were compared, and binary logistic regression analysis was carried out. The best cutoff points of the positive predictive index were obtained. Results: Type 1 (OR = 4.12, 95% CI 1.30-13.07, P =.016) and apnea hypopnea index (AHI) (OR = 1.14, 95% CI 1.05-1.24, P =.001) were risk factors, while body mass index z score (BMIz) (OR = 0.68, 95% CI 0.49-0.94, P =.018) and mean pulse oxygen saturation (MSpO ) (OR = 0.67, 95% CI 0.50-0.91, P =.010) were protective factors. The sensitivity and specificity of the standard of MSpO < 96% and AHI > 10 events/h or BMIz < -1 with the occurrence of RRTIs and/or ARF were 0.513 and 0.957, respectively. Conclusion: SMA Type 1, BMIz, AHI and MSpO should be used to estimate the risk for RRTI or ARF in children with SMA. MSpO < 96%, and AHI > 10 events/h or BMIz < -1 should be used as the intervention standard.

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“…The questionnaires could be used to assess sleep disorders in SMA, 18 but have limitations of subjectivity because nocturnal hypoventilation can also be found in pediatric SMA patients without clinical symptoms 19,20 . Sleep‐disordered breathing is associated with RRTIs in children with SMA, and long‐term noninvasive ventilation can improve PSG scores and reduce the incidence of respiratory tract infection 21 . Our study used SMA children as samples and analyzed the association between PSG scores and the occurrence of RRTIs and ARF, which ensured the objectivity of the results and applicability to SMA disease.…”

Section: Discussionmentioning

confidence: 99%

“… 19 , 20 Sleep‐disordered breathing is associated with RRTIs in children with SMA, and long‐term noninvasive ventilation can improve PSG scores and reduce the incidence of respiratory tract infection. 21 Our study used SMA children as samples and analyzed the association between PSG scores and the occurrence of RRTIs and ARF, which ensured the objectivity of the results and applicability to SMA disease. Our study showed that AHI > 10.2 events/h and MSpO 2 < 95.5% suggested a high risk for RRTIs and/or ARF in children with SMA.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for recurrent respiratory tract infections and acute respiratory failure in children with spinal muscular atrophy

Guo

Meng

Cao

2022

Pediatric Pulmonology

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Introduction: Assessment of and intervention for sleep-disordered breathing and malnutrition are related to the prevention of recurrent respiratory tract infections (RRTIs) and acute respiratory failure (ARF) in children with spinal muscular atrophy (SMA). However, specific standards for sleep-disordered breathing and malnutrition in the prevention of RRTIs and ARF have not been clarified. Purpose:The study aimed to identify the risk factors and predictive indices for RRTIs and/or ARF in children with SMA.Methods: In this retrospective study, the differences in clinical characteristics between patients with and without RRTIs and ARF were compared, and binary logistic regression analysis was carried out. The optimal cutoff points for positive predictors were obtained.Results: SMA type 1 (odds ratio (OR) = 5.21, 95% confidence interval (CI) 1.50-18.17, p = 0.010) and the apnea-hypopnea index (AHI) (OR = 1.12, 95% CI 1.01-1.24, p = 0.026) were risk factors, while the body mass index z score (BMIz) (OR = 0.65, 95% CI 0.46-0.91, p = 0.013) and mean pulse oxygen saturation (MSpO 2 ) (OR = 0.72, 95% CI 0.52-1.00, p = 0.049) were protective factors. A standard consisting of (i) MSpO 2 < 96% and (ii) AHI > 10 events/h and/or BMIz < -1 predicted the occurrence of RRTIs and/or ARF in the next year with a sensitivity of 0.513 and a specificity of 0.957. Conclusion:SMA type 1, BMIz, AHI and MSpO 2 should be used to estimate the risk of RRTI and/or ARF in children with SMA. MSpO 2 < 96% combined with AHI > 10 events/h or BMIz < -1 should be used as the intervention standard.

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Outcomes of Long-Term Noninvasive Ventilation Use in Children with Neuromuscular Disease: Systematic Review and Meta-Analysis

Cited by 15 publications

References 55 publications

Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines

Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines

Risk factors for recurrent respiratory tract infections or acute respiratory failure in children with spinal muscular atrophy

Risk factors for recurrent respiratory tract infections and acute respiratory failure in children with spinal muscular atrophy

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