Outcomes of Kimura’s Disease after Radiotherapy or Non-Radiotherapeutic Methods

Chang, Ah Ram; Kim, I.; Park, C.; Jun, Yukyung

doi:10.1016/j.ijrobp.2005.07.738

Cited by 2 publications

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“…The size of diseased regions and the peripheral blood eosinophil were all decreased after anti-IgE therapy, but complete remission of the tumor was not observed. Radiotherapy has been used in cases of refractory disease [14], and shown to be effective for local control of KD [11,15]. We treated the patient with radiotherapy and shown to be effective for local control of Kimura's disease.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Kimura’s Disease with Radiotherapy: A Case Report

Rahaman¹,

Chinnikatti²,

Miraj³

et al. 2020

SJMCR

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Case ReportKimura's disease is a rare chronic inflammatory disorder with angiolymphaticproliferation of unknown cause.It primarily involves the head and neck region, presenting as deep subcutaneous masses and is often accompanied by regional lymphadenopathy, Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration. We report a case of Kimura's disease in a 30year-old male who presented with a Rightsubcutaneous mass and cervical lymphadenopathy. Radiation therapy was performed for recurrence after surgical excision three times. The prescribed radiation dose was 45 Gy, the patient was free of the disease.

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Section: Discussionmentioning

confidence: 99%

Successful Treatment of Kimura’s Disease with Radiotherapy: A Case Report

Rahaman¹,

Chinnikatti²,

Miraj³

et al. 2020

SJMCR

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“…2 Although a tendency to develop cancer and fatal outcome have not been reported in KD, it is longlasting and refractory. 3 Patients treated with the duplicate protocol had different outcomes, with some not experiencing recurrence and others suffering. 4 Elucidation and clarification of the pathogenesis might result in more efficient molecular precision medicine.…”

Section: Introductionmentioning

confidence: 99%

Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease

Chen

Gong

et al. 2017

International Journal of Oral and Maxillofacial Surgery

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Objective To investigate the expressions of interleukin (IL)-21 and phosphorylated extracellular signal regulated kinase 1/2 ( pERK1/2) in Kimura disease (KD) and to correlate the findings with clinical and prognostic variables. Methods Immunohistochemical analysis of IL-21 and pERK1/2 was performed in 18 cases of KD and five gender-and age-matched control samples. Clinical data were extracted and patients followed up for a mean period of 32.1 months.Results After a mean follow-up period of 32.1 months (range 1-102 months), recurrence was diagnosed as the end point for seven patients-that is, a 44% (7/16) cumulative recurrence rate. In comparison with genderand age-matched controls, patients showed strong in situ expressions of IL-21 and pERK1/2, respectively ( p<0.05). Patients with strong IL-21 staining intensity and overexpression of pERK1/2 had a lower recurrence rate than those with moderate staining intensity ( p=0.049, p=0.019, respectively). However, differences were not statistically significant by gender, age, eosinophils, location, multiplicity, laterality, size, duration and primary outbreak. pERK1/2 was the independent prognostic factor ( p=0.020), while age, gender, eosinophils, multiplicity, laterality, size, duration, primary outbreak and expression of IL-21 were not. Conclusions This study suggests that the IL-21/pERK1/ 2 pathway is activated in KD, and pERK1/2 might be considered as a potential prognostic indicator in KD.

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Outcomes of Kimura’s Disease after Radiotherapy or Non-Radiotherapeutic Methods

Cited by 2 publications

References 0 publications

Successful Treatment of Kimura’s Disease with Radiotherapy: A Case Report

Successful Treatment of Kimura’s Disease with Radiotherapy: A Case Report

Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease

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