Outcomes of Kidney Transplantation From Older Living Donors to Older Recipients

Gill, Jagbir; Bunnapradist, Suphamai; Danovitch, Gabriel M.; Gjertson, David W.; Gill, John S.; Cecka, Michael

doi:10.1053/j.ajkd.2008.05.017

Cited by 147 publications

(97 citation statements)

References 29 publications

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“…Finally, using data from the OPTN/UNOS, it has been shown that early posttransplantation outcomes were best in recipients of living donors aged younger than 55 years. Recipients of organs from older donors showed inferior 3-year graft survival rates, but similar 3-year patient survival rates [35].…”

Section: Donor Kidney Function and Its Implications To The Recipientmentioning

confidence: 89%

Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

2015

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Kidney transplantation is the best treatment for patients with end-stage renal disease and recipients of living kidney donors fare better than recipients of deceased donors. In view of the shortage of organ supply and the long waiting list, expansion of the living donor pool has been sought. Importantly, donor acceptance criteria must first and foremost be grounded in concerns for donor safety. Recent studies suggesting that live kidney donors may have higher rates of end-stage renal disease in the long term compared with otherwise similar healthy persons highlights the critical importance of pre-donation evaluation of renal function and structure, and careful application in donor selection criteria. The quality of organs from living donors may also affect recipient outcomes. Because donor kidney function, histology, and anatomy pertain to the quality of the donated organ, living donor characterization of the factors associated with these features is important to the donor as well as the recipient.

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Section: Donor Kidney Function and Its Implications To The Recipientmentioning

confidence: 89%

Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

2015

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“…For example, among those aged 74 years, receiving a deceased donor transplant was associated with a hazard ratio of mortality of 0.67 (95 % confidence interval 0.53, 0.86) as compared to remaining on dialysis [23]. Use of expanded criteria deceased donors [24,25] as well as more liberal use of older living donors [26] also appear to reduce mortality among older people with kidney failure, as compared to similar patients who remain on the transplant waiting list (Box 2). These latter two strategies are especially appealing for use in developing countries, where growth in the prevalence of older people has been most pronounced.…”

Section: Kidney Transplantation Can Also Benefit Older People With Kimentioning

confidence: 99%

Chronic kidney disease and the aging population

Riella

2014

J Nephrol

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“…Elderly deceased criteria donor transplantations were associated with a greater risk of graft loss. He proposed old living donors an important option for elderly transplantation (Gill et al, 2008). There are other few studies in the literature that found encouraging results with elderly living donor transplants (Kumar et al, 2000;De La Vega, 2004).…”

Section: Aged Kidney Donorsmentioning

confidence: 99%