Outcomes of Interferon/Ribavirin Therapy in Patients with HCV Defined by Expression of Plasma Soluble Human Leukocyte Antigen-G but Not IL-37

Ding, Shi-xiong; Ma, Jianbo; Hu, Yaoren; Hu, Airong; Shen, Qiang; Gao, Guosheng

doi:10.12659/msm.895971

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Consistent with our findings, a recent study reported that IL-37 mRNA expression and serum protein concentration are higher in patients with TB than in healthy donors (29). Similarly, mRNA expression and serum concentrations of IL-37 are increased in patients with chronic hepatitis C virus (36), hepatitis B virus (37), and HIV-1 (38). Several studies have identified many cytokines that play important roles in susceptibility/resistance to Mtb infection.…”

Section: Discussionsupporting

confidence: 91%

Association of IL‐37 gene polymorphisms with susceptibility to tuberculosis in Saudi subjects

Allam

Mohamed

Alswat

et al. 2016

Microbiology and Immunology

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Tuberculosis (TB) is one of the most common infectious diseases worldwide. IL-37, a novel member of the IL-1 family, has anti-inflammatory activity. Various cytokine genes polymorphisms are reportedly associated with susceptibility to TB infection. However, an association between genetic variations in the IL-37 gene and susceptibility to TB infection has not been investigated. The aim of this case-control study was therefore to identify such an association in Saudi subjects, in which five single-nucleotide polymorphisms (SNPs) in the IL-37 gene were assessed. Serum concentrations of IL-37 were evaluated using ELISA, and genetic variants genotyped by multiplex PCR and ligase detection reaction. It was found that the C/C genotype of rs2723176 (-6962 A/C) occurs significantly more frequently in patients with active TB and that the C allele of this SNP is associated with TB. In addition, the C allele of rs2723176 SNP was associated with high circulating concentrations of IL-37. However, the genotype and allele frequency of the other four SNPs (rs3811046, rs3811047, rs2723186 and rs2723187) were not significantly associated with TB infection. In conclusion, the present data suggest that rs2723176 SNP of IL-37 is involved in the development of TB infection. Furthermore, high circulating concentrations of IL-37 may have a negative effect on protective immunity against TB infection.

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Section: Discussionsupporting

confidence: 91%

Association of IL‐37 gene polymorphisms with susceptibility to tuberculosis in Saudi subjects

Allam

Mohamed

Alswat

et al. 2016

Microbiology and Immunology

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“…Only three of the 19 analyzed studies were of modest sample size, with n ≥ 100, yet none were ≥ 120. Ding et al (64) conducted the largest study, including 112 healthy subjects, and reported a mean (SD) plasma IL-37 level of 47.6 (5.9) pg/mL, which computes to a range of 35.8 -59.5 pg/mL. This range may be considered too narrow based on the results of this metaanalysis.…”

Section: Discussionmentioning

confidence: 85%

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

Santarelli¹,

Vincent

Rudloff

et al. 2021

Front. Immunol.

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Interleukin (IL)-37 has an important function in limiting excessive inflammation. Its expression is increased in numerous inflammatory and autoimmune conditions and correlates with disease activity, suggesting it could have potential as a disease biomarker. Nevertheless, a reference range has yet to be determined. Our aim was to establish the first reference range of circulating IL-37 levels in healthy adult humans. PubMed was searched for studies reporting blood IL-37 concentrations in healthy adult subjects as measured by enzyme-linked immunosorbent assay. Nineteen studies were included in the analysis. Mean IL-37 levels were weighted by sample sizes, and weighted mean lower and upper levels ( ± 2SD of means) were calculated to provide a weighted mean and reference range. IL-37 levels were quantified in either serum or plasma from a total of 1035 (647 serum; 388 plasma) healthy subjects. The serum, plasma and combined matrix weighted means (reference ranges) were 72.9 (41.5 – 104.4) pg/mL, 83.9 (41.1 – 126.8) pg/mL, and 77.1 (41.4 – 112.8) pg/mL, respectively. There were no significant differences between serum and plasma means and upper and lower limits. Study means and upper IL-37 levels were significantly higher in Chinese population studies. From our analysis, a preliminary reference range for circulating IL-37 levels in healthy human adults has been established. In order to determine a reliable reference range for clinical application, large, prospective, multi-ethnic, healthy population studies are necessary. In addition, demographics, sample matrix, collection, processing and storage methods potentially affecting IL-37 detection levels should be thoroughly investigated.

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“…In contrast, one study evaluating HLA‐G and anti‐HCV in patients on the waiting list for kidney transplantation was not able to find significant difference in all anti‐HCV positive groups regarding HLA‐G expression, although none of the patients showed active infection (Sommese et al., 2018). In addition, studies comparing expression levels of immunomodulatory genes, including HLA‐G , before and after treatment with pegylated interferon in combination with ribavirin and other with anti‐viral agent silibinin pointed to a higher HLA‐G expression in HCV+ patients before treatment (Castellaneta et al., 2016; Ding et al., 2016). The findings of the two previously mentioned studies highlight a possible influence of the infection in HLA‐G expression.…”

Section: Discussionmentioning

confidence: 99%

HLA‐G 3′UTR haplotype analyses in HCV infection and HCV‐derived cirrhosis, hepatocellular carcinoma and fibrosis

Oliveira Correa,

Zambra,

Michita

et al. 2023

Int J Immunogenetics

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Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Chronic HCV infection is also an important cause of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC). HCV has the capacity to evade immune surveillance by altering the host immune response. Moreover, variations in immune‐related genes can lead to differential susceptibility to HCV infection as well as interfere on the susceptibility to the development of hepatic fibrosis, cirrhosis and HCC. The human leucocyte antigen G (HLA‐G) gene codes for an immunomodulatory protein known to be expressed in the maternal–foetal interface and in immune‐privileged tissues. The HLA‐G 3′ untranslated region (3′UTR) is important for mRNA stability, and variants in this region are known to impact gene expression. Studies, mainly focusing in a 14 bp insertion/deletion polymorphism, have correlated HLA‐G 3′UTR with susceptibility to viral infections, but other polymorphic variants in the HLA‐G 3′UTR might also affect HCV infection as they are inherited as haplotypes. The present study evaluated HLA‐G 3′UTR polymorphisms and performed linkage disequilibrium test and haplotype assembly in 286 HCV infected patients who have developed fibrosis, cirrhosis or HCC, as well as in 129 healthy control subjects. Haplotypes UTR‐1, UTR‐2 and UTR‐3 were the most observed in HCV+ patients, in the frequencies of 0.276, 0.255 and 0.121, respectively. No statistically significant difference was observed between HCV+ and control subjects, even when patients were grouped according to outcome (HCC, cirrhosis or fibrosis). Despite that, some trends in the results were observed, and therefore, we cannot rule out the possibility that variants associated to high HLA‐G expression can be involved in HCV infection susceptibility.

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Outcomes of Interferon/Ribavirin Therapy in Patients with HCV Defined by Expression of Plasma Soluble Human Leukocyte Antigen-G but Not IL-37

Cited by 6 publications

References 28 publications

Association of IL‐37 gene polymorphisms with susceptibility to tuberculosis in Saudi subjects

Association of IL‐37 gene polymorphisms with susceptibility to tuberculosis in Saudi subjects

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

HLA‐G 3′UTR haplotype analyses in HCV infection and HCV‐derived cirrhosis, hepatocellular carcinoma and fibrosis

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