Association of IL‐37 gene polymorphisms with susceptibility to tuberculosis in Saudi subjects

Abstract

Tuberculosis (TB) is one of the most common infectious diseases worldwide. IL-37, a novel member of the IL-1 family, has anti-inflammatory activity. Various cytokine genes polymorphisms are reportedly associated with susceptibility to TB infection. However, an association between genetic variations in the IL-37 gene and susceptibility to TB infection has not been investigated. The aim of this case-control study was therefore to identify such an association in Saudi subjects, in which five single-nucleotide polymorphisms (SNPs) in the IL-37 gene were assessed. Serum concentrations of IL-37 were evaluated using ELISA, and genetic variants genotyped by multiplex PCR and ligase detection reaction. It was found that the C/C genotype of rs2723176 (-6962 A/C) occurs significantly more frequently in patients with active TB and that the C allele of this SNP is associated with TB. In addition, the C allele of rs2723176 SNP was associated with high circulating concentrations of IL-37. However, the genotype and allele frequency of the other four SNPs (rs3811046, rs3811047, rs2723186 and rs2723187) were not significantly associated with TB infection. In conclusion, the present data suggest that rs2723176 SNP of IL-37 is involved in the development of TB infection. Furthermore, high circulating concentrations of IL-37 may have a negative effect on protective immunity against TB infection.

Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population

“…(2014) showed that decreased expression of IL-37 was correlated with HCC progression 23 , and elevated serum IL-37 levels have been observed in patients infected with HBV and treated with telbivudine 24 . Several studies have shown that there is a significant association between certain genetic variations within the IL-37 gene and several diseases, including tuberculosis 25,26 , coronary artery disease (CAD) 27 , and autoimmune-based thyroid diseases 28 .…”

Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs

“…HAP1 contained the rs3811046 and rs3811047 SNPs in the IL37 gene. These SNPs are the most commonly studied in the literature for the IL37 gene [ 1 , 10 , 14 , 42 , 43 , 63 , 65 , 68 ]. We observed that having more copies of the minor allele of HAP1 tended to be related to lower diastolic blood pressure and adiposity, indicating a protective effect of these SNPs.…”

Polymorphism Analysis of Interleukin-18 and Interleukin-37 Genes in Hepatitis B Infections with Different Outcomes: A Preliminary Report from an Iranian Population

“…Moreover, Zhao et al stated that decreased IL-37 production is associated with HCC progression (Zhao et al, 2014). According to several studies, certain genetic variations within the IL-37 gene are associated with several diseases such as tuberculosis (Allam et al, 2016;Liu et al, 2017), coronary artery disease (CAD) (Yin et al, 2017), and autoimmune-based thyroid diseases (Yan et al, 2015).…”