Outcomes of intense pulsed light therapy for treatment of evaporative dry eye disease

Gupta, Preeya K.; Vora, Gargi K.; Matossian, Cynthia; Kim, Michelle; Stinnett, Sandra S.

doi:10.1016/j.jcjo.2016.01.005

Cited by 107 publications

(117 citation statements)

References 25 publications

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“…The third limitation was that the treatment included Optima™ IPL sessions immediately followed by MGX, as was done in other studies 13,15,16. Although expression does not address the root cause, it may help reduce the severity of the condition, by clearing clogged meibomian glands and allowing them to heal and function more properly.…”

Section: Limitationsmentioning

confidence: 99%

Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction

Dell¹,

Gaster²,

Barbarino³

et al. 2017

OPTH

117

115

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PurposeThe aim of this study was to estimate the efficacy of intense pulsed light (IPL), followed by meibomian gland expression (MGX), for reducing the number and severity of signs and symptoms of dry eye disease (DED) secondary to meibomian gland dysfunction (MGD).Patients and methodsIn a prospective study conducted in two sites, 40 subjects (80 eyes) with moderate to severe MGD were enrolled. Major inclusion criteria consisted of at least two of the following measures being compatible with DED in both eyes: tear breakup time (TBUT), meibomian gland score (MGS), corneal fluorescein staining (CFS), Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and tear film osmolarity (TFO). Enrolled patients underwent four treatment sessions, 3 weeks apart. Each treatment included the administration of 10–15 pulses of IPL on the cheeks and nose, followed by MGX of the upper and lower eyelids. TBUT, MGS, CFS, SPEED, TFO, and lipid layer thickness (LLT) were measured at baseline (BL) and at 9, 12, and 15 weeks after BL.ResultsDue to different staining methods used for TBUT measurements, TBUT and CFS were analyzed separately for each site. From BL to the final follow-up, the number of signs compatible with DED decreased from 3.3±0.1 to 1.4±0.1. TBUT improved by +93% (n=38; P<0.0001) and +425% (n=42; P<0.0001) for sites 1 and 2, respectively. SPEED, MGS, and CFS improved by −55% (n=80; P<0.0001), −36% (n=80; P<0.0001), and −58% (n=38; P<0.0001), respectively. In 20 eyes with abnormally elevated TFO at BL, TFO improved by −7% (n=20; P<0.005). LLT did not change (n=38; P=0.88).ConclusionIn subjects with moderate to severe MGD, IPL combined with MGX reduced the number and severity of symptoms and signs of DED. Except for LLT, all examined outcome measures significantly improved after 15 weeks. These results support the efficacy of IPL + MGX in relieving both signs and symptoms of DED secondary to MGD.

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Section: Limitationsmentioning

confidence: 99%

Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction

Dell¹,

Gaster²,

Barbarino³

et al. 2017

OPTH

117

115

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“…In our own retrospective review, 37 patients with a diagnosis of evaporative dry eye disease underwent three or more IPL treatments [16]. Patients were examined at each visit for tear break-up time, and grading of eyelid and facial vascularity, eyelid margin edema, meibomian gland oil flow, and oil quality as described previously by Mathers [17].…”

Section: Treatment Outcomesmentioning

confidence: 99%

“…Oftentimes, maintenance treatments are necessary every 6-12 months. [16] SAFETY PROFILE Although IPL has a relatively good safety profile, some ocular complications have been reported when used without proper eye protection. Lee et al [19] reported two patients with anterior uveitis, permanent iris atrophy and pupillary defects causing longlasting photophobia and pain after receiving periorbital IPL treatment.…”

Section: Treatment Outcomesmentioning

confidence: 99%

Intense pulsed light therapy for the treatment of evaporative dry eye disease

Vora

Gupta

2015

Current Opinion in Ophthalmology

Self Cite

114

110

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“…It is clinically manifested through dryness, irritation, foreign body sensation, burning, excessive tearing, redness, itching, fatigue, recurrent infections, and transient visual disturbances [4]. Some studies have compared the impact on the quality of life of patients with dry eye to moderate / severe angina or dialysis treatment [7]. Thus, the symptoms may represent a severe functional impairment to the individual with DES.…”

Section: Introductionmentioning

confidence: 99%

“…A recent alternative implemented in the treatment of MGD is the use of Intense Pulsed Light (IPL). It consists of the emission of visible, high-intensity polychromatic light at wavelengths of 500-1200nm, through equipment adapted with xenon lash lamp [7][8][9]. The emitted light is capable of producing perfectly calibrated and homogeneous light pulse sequences.…”

Section: Introductionmentioning

confidence: 99%

Dry eye syndrome: Therapeutic challenges and future trends

Araújo-Neto¹,

Rêgo²,

Araújo‐Filho³

2019

Int J Clin Exp Ophthalmol

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Introduction:Intense Pulsed Light (IPL) is the therapeutic tool implemented in the treatment of dry eye, characterized by the emission of waves of 500-1200nm in the region of the upper and lower eyelids. Dry eye is a recurring complaint in ophthalmology offi ces and has an impact on the patient's quality of life. It results from dysfunction of the meibomian glands, duct obstruction, and quantitative and qualitative changes in glandular secretion. It is manifested by dryness and irritation, foreign body sensation, burning, tearing, and eye fatigue. The available treatments are short term palliative with unsatisfactory results. Objective:To determine through a literature review, the benefi t of using intense pulsed light for dry eye treatment. Methodology: We searched the Cochrane database, PubMed, Embase, Scopus, Web of Science, and Google Scholar (gray literature) using the keywords for an independent, blinded, peer-reviewed selection of articles to be met following pre-established criteria.Results and discussion: Studies evaluated the use of IPL in patients with dry eye, despite the benefi t found, focus on the objective and subjective assessment of the eye more frequently. Conclusion:Evidence-based clinical guidelines are required for the use of intense pulsed light in the treatment of Meibomian Gland Dysfunction (MGD), as well as a device and algorithm for indications of therapeutic use. Dry eye syndrome: Therapeutic challenges and future trends

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Outcomes of intense pulsed light therapy for treatment of evaporative dry eye disease

Cited by 107 publications

References 25 publications

Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction

Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction

Intense pulsed light therapy for the treatment of evaporative dry eye disease

Dry eye syndrome: Therapeutic challenges and future trends

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