Outcomes of COVID-19 in Solid Organ Transplant Recipients: A Propensity-matched Analysis of a Large Research Network

Hadi, Yousaf; Naqvi, Syeda Fatima; Kupec, Justin; Sofka, Sarah; Sarwari, Arif R.

doi:10.1097/tp.0000000000003670

Cited by 96 publications

(70 citation statements)

References 17 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 4 , 5 , 19 , 20 , 21 Compared with earlier reports of mortality approaching 30%, in a more current series of 2307 solid organ transplant recipients with COVID-19 (8% lung transplant and 11% heart transplant recipients), 30-day mortality was 4.8%. 22 However, while the mortality of COVID-19 in lung transplant recipients may not be as high as originally feared, ongoing issues remain regarding the potential for long-term effects on allograft function, including acceleration of chronic allograft loss, as seen with other viral respiratory tract infections. In addition, the ideal adjustment of immunosuppression regimens to mitigate disease severity has not been established.…”

Section: Covid-19 In Lung Transplantationmentioning

confidence: 99%

Covid-19 in recipients of heart and lung transplantation: Learning from experience

Kittleson

Chambers

Cypel

et al. 2021

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Covid-19 In Lung Transplantationmentioning

confidence: 99%

Covid-19 in recipients of heart and lung transplantation: Learning from experience

Kittleson

Chambers

Cypel

et al. 2021

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

show abstract

“…Solid-organ transplant (SOT) recipients are at greater risk of significant coronavirus disease 2019 (COVID-19) related morbidity and mortality. 1 Immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered one of the most promising strategies to alleviate unfavorable consequences among SOT recipients and their allograft.…”

Section: Brief Reportmentioning

confidence: 99%

SARS-CoV-2-specific Humoral Immune Responses after A Single dose of Inactivated Whole-virus SARS-CoV-2 Vaccine in Kidney Transplant Recipients: An Initial Report

Bruminhent

Boongird

Assanatham

et al. 2021

Preprint

View full text Add to dashboard Cite

We presented an initial pilot study report focused on immunogenicity and safety following an inactivated whole virus severe acute respiratory syndrome coronavirus 2 vaccination among kidney transplant (KT) recipients. At four weeks after the first dose of vaccine, the level of anti RBD IgG antibody was not significantly different compared to before vaccination in 30 KT recipients (p = 0.45). Moreover, a significant lower mean (95% CI) anti RBD IgG antibody was observed compared to 30 immunocompetent controls (2.4 [95% CI 1.3 to 3.5] vs. 173.1 [95% CI 88.3-2,457.9] AU/mL, p < 0.001). Mild adverse events included fever (17%) and localized pain at the injection site (14%) were observed after vaccination.

show abstract

“…Some studies demonstrated that SOT recipients hospitalized with COVID-19 showed similar overall outcomes as hospitalized non-SOT recipients with other chronic conditions (obesity, diabetes, and hypertension), suggesting that chronic immunosuppression may not be an independent risk factor for poor outcomes in COVID-19 patients requiring hospitalization [ 6 ]. However, other studies reported that SOT status independently increases the risk of hospital admission and acute kidney injury (AKI) in COVID-19 patients [ 7 ]. Bajpai et al reported a 29% rate of post-COVID-19 AKI in kidney transplant recipients [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Severe COVID-19 by SARS-CoV-2 Lineage B.1.1.7 in Vaccinated Solid-Organ Transplant Recipients: New Preventive Strategies Needed to Protect Immunocompromised Patients

et al. 2021

View full text Add to dashboard Cite

Background: Solid-organ transplant (SOT) recipients are at a high risk of severe COVID-19, and are priority for vaccination. Here, we describe three cases of severe COVID-19 caused by SARS-CoV-2 B.1.1.7 lineage in vaccinated SOT recipients. Methods: Three SOT patients were hospitalized in the Policlinico Hospital of Bari (southern Italy) and underwent nasopharyngeal swabs for molecular detection of SARS-CoV-2 genes and spike protein mutations by real-time PCR. One sample was subjected to whole-genome sequencing. Results: One patient was a heart transplant recipient and two were kidney transplant recipients. All were hospitalized with severe COVID-19 between March and May 2021. Two patients were fully vaccinated and one had received only one dose of the BNT162b2 mRNA vaccine. All the patients showed a high viral load at diagnosis, and molecular typing revealed the presence of B.1.1.7 lineage SARS-CoV-2. In all three cases, prolonged viral shedding was reported. Conclusions: The three cases pose concern about the role of the B.1.1.7 lineage in severe COVID-19 and about the efficacy of COVID-19 vaccination in immunocompromised patients. Protecting immunocompromised patients from COVID-19 is a challenge. SOT recipients show a suboptimal response to standard vaccination, and thus, an additive booster or a combined vaccination strategy with mRNA, protein/subunit, and vector-based vaccines may be necessary. This population should continue to practice strict COVID-19 precautions post-vaccination, until new strategies for protection are available.

show abstract

Outcomes of COVID-19 in Solid Organ Transplant Recipients: A Propensity-matched Analysis of a Large Research Network

Cited by 96 publications

References 17 publications

Covid-19 in recipients of heart and lung transplantation: Learning from experience

Covid-19 in recipients of heart and lung transplantation: Learning from experience

SARS-CoV-2-specific Humoral Immune Responses after A Single dose of Inactivated Whole-virus SARS-CoV-2 Vaccine in Kidney Transplant Recipients: An Initial Report

Severe COVID-19 by SARS-CoV-2 Lineage B.1.1.7 in Vaccinated Solid-Organ Transplant Recipients: New Preventive Strategies Needed to Protect Immunocompromised Patients

Contact Info

Product

Resources

About