Outcomes of catheter-directed treatment of lower extremity deep vein thrombosis of patients presenting to a tertiary care hospital

Abstract

Background:Lower extremity deep vein thrombosis (DVT) is a common illness with an annual incidence of 1 per 1000 adults. The major long-term complication of DVT is post-thrombotic syndrome (PTS) which occurs in up to 60% of patients within 2 years of an episode of DVT.Aims:We aim to evaluate the outcomes of catheter-directed treatment (CDT) for symptomatic acute or subacute lower extremity DVT.Materials and Methods:A retrospective 12-year study was conducted on the outcomes of CDT on 54 consecutive patients who presented with acute or subacute lower extremity DVT to our hospital.Statistical Analysis:Descriptive summary statistics and the Chi-square test were used to measure the outcomes of CDT.Results:Grade 3 thrombolysis was achieved in 25 (46.3%) patients, grade 2 thrombolysis in 25 (46.3%) patients, and grade 1 thrombolysis in 4 (7.4%) patients. Significant recanalization (grade 2 or 3 thrombolysis) was possible in 50 (92.6%) patients. There was no statistically significant difference in the percentage of significant recanalization that could be achieved between patients who underwent CDT before and after 10 days. There was no significant difference between the thrombolysis achieved between urokinase and r-tPA. PTS was seen in 33% of the patients. Major complications were seen in 5.5% of the patients.Conclusion:CDT is a safe and effective therapeutic technique in patients with acute and subacute lower extremity DVT, if appropriate patient selection is made.

Effect of miR-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1

“…According to a recent study, LEDVT prevalence is approximately 1 out of 1000 adults every year [ 4 ]. Local pain, tenderness, edema, and swelling of the lower extremity are the most commonly found symptoms amongst LEDVT patients; however, over 30% of these cases present no signs or symptoms until an association is involved above the knee [ 5 ]. Although the Society of Interventional Radiology and the Society for Vascular Surgery has published quality improvement guidelines for the treatment of LEDVT and a relatively large amount of studies have reported a series of treatment options, no effective pharmacological methods that prevent thrombus-related damage to the vein wall in order to diminish the risk have been discovered [ 6 ].…”

Recombinant Tissue Plasminogen Activator Treatment of Pulmonary Embolism Also Improves Deep Venous Thrombosis

“…It is thought to result from chronic venous hypertension, which results from damage to the venous valves by thrombosis. PTS may occur in up to 60% of patients within 2 years of an episode of DVT 10. It is traditionally managed conservatively with graded compression stockings and limb elevation.…”

“…Lower extremity DVT is a common illness with an annual incidence rate of 1 per 1000 adults 9. Virchow's triad is still used to explain the mechanism of the formation of the thrombus in the venous system 10 11. Hypercoagulability, stasis and endothelial damage are the components of the triad.…”

Association of interleukin‐18 gene polymorphism and its protein expression with the lower extremity deep venous thrombosis in the chinese han population: A case‐control study

“…7 Acute DVT may result in PE, thrombus progression, phlegmasia cerulea dolens, venous gangrene, phlegmasia alba dolens, and even death. 8 The standard treatment for DVT is oral anticoagulation, aiming to restrict the thrombus propagation and reduce PE risk. 9 As a prevalent disorder, various genetic factors have been indicated to affect the susceptibility toward thrombosis as well as DVT incidence.…”