Outcomes in Patients with Helicobacter pylori Undergoing Laparoscopic Sleeve Gastrectomy

Brownlee, Andrew; Bromberg, Erica; Roslin, Mitchell

doi:10.1007/s11695-015-1687-6

Cited by 34 publications

(9 citation statements)

References 24 publications

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“…Some findings may vary according to geographic distributions. For example, the frequency of HP infections can vary from 3.2% to 64% (15)(16)(17)(18)(19)10,(20)(21)(22)(23). This rate was 35% in our series.…”

Section: Discussionmentioning

confidence: 47%

Unexpected Histopathological Findings After Laparoscopic Sleeve Gastrectomy

Batman¹,

Altun²

2020

Istanbul Med J

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Amaç: Obezite sıklığı tüm dünyada artmaktadır. Laparoskopik sleeve gastrektomi (LSG) günümüzde dünya genelinde en sık uygulanan bariatrik cerrahi olarak yerini almıştır. Diğer bariatrik cerrahilerin aksine LSG'de patolojik inceleme yapılabilecek bir piyes çıkmaktadır. Bu çalışmanın amacı LSG'yi takiben beklenmeyen histopatolojik bulguları tanımlamaktır. Results: One thousand three hundred sixty four patients underwent LSG. The mean age was 40.93±10.86 years; 974 patients (71.48%) were female. The mean BMI was 42.23±7.28. The most common findings in the pathologies were normal gastric specimen (50%), gastritis (30%) and changes due to proton pump inhibitor use (23%) respectively. Conclusion: Gastroscopy should be added to the preoperative preparation process in cases where there is no gastric specimen after the operation. Preoperative gastroscopy is not a necessity for laparoscopic sleeve gastrectomy. It can be performed in selected cases.

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Section: Discussionmentioning

confidence: 47%

Unexpected Histopathological Findings After Laparoscopic Sleeve Gastrectomy

Batman¹,

Altun²

2020

Istanbul Med J

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“…Recently, many studies indicated that gut microbiota plays a key role in maintaining host body homeostasis [1, 6]. Helicobacter pylori is an important member of the microbiome affecting >50% of the world population and is related to the development of diverse gastric and extragastric diseases, such as gastric cancer, chronic gastritis, gastric ulcers, and duodenal and peptic ulcers [7, 8]. The rates of H. pylori infection in obese patients with gastrointestinal disorders (GID) varies geographically.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Helicobacter pylori Genotypes in Obese Patients with Gastric Ulcer, Duodenal Ulcer, and Gastric Cancer: An Observational Study

Farsimadan¹,

Heravi²,

Emamvirdizadeh³

et al. 2021

Dig Dis

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Introduction: Obesity is a well-known risk factor for a variety of gastrointestinal disorders (GID). Helicobacter pylori is associated with different GID, such as gastric cancer and chronic gastritis. In this study, we investigated the prevalence of dominant genotypes in H. pylori isolated from obese patients diagnosed with gastric ulcer, duodenal ulcer, and gastric cancer. Methods: A total of 222 H. pylori-positive samples were collected from patients with obesity. GID and gastric cancer were identified by endoscopy and histopathology, respectively. Three biopsy specimens from the gastric antrum were obtained from each patient for culture tests, histological examination, and identification of vacuolating cytotoxin A (vacA) (vacA s1, vacA s2, vacA m1, vacA m2, vacA s1m1 vacA s1m2, vacA s2m1, and vacA s2m2), cagA, cagE, iceA1, oipA, dupA, and babA2 using polymerase chain reaction. Results: vacA, cagE, cagA, iceA1, oipA, dupA, and babA2 genes were detected in 222 (100%), 171 (77%), 161 (72.5%), 77 (34.6%), 77 (34.6%), 137 (61%), and 69 (31%) patients with obesity, respectively. Our findings revealed that vacA, iceA1, oipA, and babA2 were significantly associated with a higher risk of GID, while cagE, cagA, and dupA indicated no correlation with the development of GID. Also, in the combination of s- and m-region genotypes, s1m2 (79%) was the most frequently identified genotype in patients with obesity. A significant association was also found between cagA and the presence of vacA genotypes (except for vacA m1 and babA2). Conclusions: This study indicated the high prevalence of different virulence genes in H. pylori isolated from obese patients and supported the significant role of H. pylori in the development of GID.

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“…In reality, the number and seriousness of pathology diagnostics after bariatric surgery is substantial (17) mainly because of Helicobacter Pylori (HPyl) gastric infection. As after any gastric surgery, HPyl may also generate early post bariatric complications (18) fact that makes diagnostic and treatment of HPyl infestation, a priority (19).…”

Section: Introductionmentioning

confidence: 99%

Digital quantification of chronic gastric wall inflammation in asymptomatic bariatric patients after laparoscopic sleeve gastrectomy

Vrabie¹,

Geavlete

Gangal³

2020

Preprint

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Aim: to evaluate validity of digital quantification when compared with human fast-scoring in routine classification of chronic gastric wall inflammation. Method: 87 bariatric gastric samples coming from asymptomatic severe obese patients were examined and classified as normal, with unspecified chronic gastritis and lymphocytic gastritis using a fast-scoring, visual analogue scale method. Results were compared with digital diagnostic data (manual segmentation, supervised learning analysis based on intraepithelial lymphocytes count criteria). Discordant results were re-evaluated by the human pathologist by direct count (ground truth). Helicobacter Pylori diagnostic was performed in all cases (Giemsa). Results: Digital analysis classified chronic inflammation as lymphocytic gastritis in 45 cases (mean 53 lymphocytes / 100 epithelial gastric cells SD 18). 30 cases were labeled as unspecific chronic gastritis (mean 25/100 SD 2.8) (p<0.0001). Human fast-scoring classified 43 cases as lymphocytic gastritis and 20 as unspecific gastritis. Helicobacter Pylori was detected in 49% of lymphocytic gastritis cases and in 7% of chronic gastritis. 47 diagnostics were concordant (54%). In 36%, digital score was better than human fast-scoring. In 7%, digital results were false negative (all cases generated by technical artifacts). Overall, digital quantification had 89% accuracy and 96% precision when compared with ground truth. Conclusion: In our study, digital image analysis produced a fast and reproducible classification of chronic gastric inflammation with good precision and accuracy. Technical errors generated 6 cases of false negative results. Several other limitations of the study (use of only bariatric gastric fundus tissue, low number of cases, manual supervised learning segmentation) ask for an increased number of cases evaluation before validation and clinical use.

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Outcomes in Patients with Helicobacter pylori Undergoing Laparoscopic Sleeve Gastrectomy

Abstract: Our data suggests that there is no increase in early complications in patients with H. pylori undergoing VSG. If these findings are confirmed in a long-term follow-up, it would mean that preoperative H. pylori screening in patients scheduled for VSG is not necessary.

Cited by 34 publications

References 24 publications

Unexpected Histopathological Findings After Laparoscopic Sleeve Gastrectomy

Unexpected Histopathological Findings After Laparoscopic Sleeve Gastrectomy

Evaluation of <b><i>Helicobacter pylori</i></b> Genotypes in Obese Patients with Gastric Ulcer, Duodenal Ulcer, and Gastric Cancer: An Observational Study

Digital quantification of chronic gastric wall inflammation in asymptomatic bariatric patients after laparoscopic sleeve gastrectomy

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