Evaluation of &lt;b&gt;&lt;i&gt;Helicobacter pylori&lt;/i&gt;&lt;/b&gt; Genotypes in Obese Patients with Gastric Ulcer, Duodenal Ulcer, and Gastric Cancer: An Observational Study

Farsimadan, Marziye; Heravi, Fatemah Sadeghpour; Emamvirdizadeh, Alireza; Moradi, Samaneh; Iranpoor, Hamidreza; Tabasi, Ehsan; Eskandarion, Mohammadreza; Азизян, Р. И.; Tabasi, Mohsen

doi:10.1159/000517262

Cited by 6 publications

(6 citation statements)

References 30 publications

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Section: Discussionmentioning

confidence: 99%

“…A recent observational study revealed a high prevalence of vacA and cagE followed by cagA, dupA, iceA1, oipA, and babA2 genotypes in H. pylori strains isolated from obese patients diagnosed with gastric ulcer, duodenal ulcer, and gastric cancer. 38 Moderate consumption of the 'refined grains' food group, characterized by breads, cakes, cookies, and breakfast cereal, was positively associated with H. pylori infection. These foods are rich in carbohydrates with a high glycemic index and are present in the diet of Brazilians.…”

Section: Therapeutic Advances In Gastroenterologymentioning

confidence: 98%

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Dietary habits and Helicobacter pylori infection: is there an association?

Soares

Moraes

Ramos

et al. 2023

Therap Adv Gastroenterol

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Background: Helicobacter pylori ( H. pylori) is a group 1 carcinogen and the etiological agent of gastric diseases such as gastritis, ulcers, and gastric cancer. It infects approximately half of the world’s population. Risk factors associated with H. pylori infection include socioeconomic status, lifestyle, and diet. Objectives: This study aimed to evaluate the association between eating habits and H. pylori infection in patients from a reference hospital in Central Brazil. Design: This cross-sectional study included 156 patients from 2019 to 2022. Methods: Data were collected using a structured questionnaire on sociodemographic and lifestyle characteristics and a validated food frequency questionnaire. The H. pylori infection status (positive versus negative) was determined using the histopathological method. After grams/day, foods were stratified into tertiles of consumption (low, medium, and high). Simple and multiple binary logistic regression models were used in the analysis of odds ratios (ORs) and their respective 95% confidence intervals (CIs), with a 5% significance level. Results: The prevalence of H. pylori infection was 44.2% (69/156 patients). Infected individuals had a mean age of 49.6 ± 14.6 years; 40.6% were men, 34.8% were aged 60 years or older, 42.0% were unmarried, 7.2% had higher education, 72.5% were non-white, and 30.4% were obese. In the H. pylori-positive group, 55.1% were alcohol drinkers and 42.0% were smokers. The results of multiple analyses showed that the chance of H. pylori infection was higher among male participants (OR = 2.25; CI = 1.09–4.68) and individuals with obesity (OR = 2.68; CI = 1.10–6.51). Participants with moderate consumption of refined grains (bread, cookies, cakes, breakfast cereal) (OR = 2.41; CI = 1.04–5.62) and fruits (OR = 2.53; CI = 1.08–5.94) were more likely to be infected. Conclusion: In this study, male sex, obesity, and the consumption of refined grains and fruits were positively associated with H. pylori infection. Further research is needed to investigate this association and elucidate the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Therapeutic Advances In Gastroenterologymentioning

confidence: 98%

Dietary habits and Helicobacter pylori infection: is there an association?

Soares

Moraes

Ramos

et al. 2023

Therap Adv Gastroenterol

View full text Add to dashboard Cite

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“…These cells feature a strong affinity for deamidated gluten-derived peptides, which bind and present to CD4 T cells in suburothelium, starting up the inflammatory cascade, which is a function of CD. Auto-antibodies against TG2, specifically anti-TG2 and anti- EMA, are responsible for the deamination of gluten in CD patients [ 22 , 23 ] . However, the most important alteration is intestinal damage, often characterized by villous atrophy, a scientific feature in most CD cases.…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease: A Review from Genetic to Treatment

Jafari,

Soleymani,

Hamidi

et al. 2024

IBJ

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Celiac disease is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD.

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“…The spiral‐shaped bacterium has 3–5 polar flagella that are utilized for locomotion and is positive for the urease, catalase, and oxidase enzymes 2 . Most H. pylori strains express virulence factors that have evolved it interfere with host cell signalling pathways, this remarkable ability to persist for decades in the harsh stomach environments, primarily because the host cannot effectively eliminate it 3,4 . By utilizing urease to convert urea into ammonia, H. pylori has acquired the ability to thrive in the extremely acidic environment, setting it apart from other viruses and bacteria 5 .…”

Section: Introductionmentioning

confidence: 99%

Gene silencing of Helicobacter pylori through newly designed siRNA convenes the treatment of gastric cancer

Reza,

Mahmud,

Ferdous

et al. 2023

Cancer Medicine

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BackgroundHelicobacter pylori is a gastric pathogen that is responsible for causing chronic inflammation and increasing the risk of gastric cancer development. It is capable of persisting for decades in the harsh gastric environment because of the inability of the host to eradicate the infection. Several treatment strategies have been developed against this bacterium using different antibiotics. But the effectiveness of treating H. pylori has significantly decreased due to widespread antibiotic resistance, including an increased risk of gastric cancer. The small interfering RNAs (siRNA), which is capable of sequence‐specific gene‐silencing can be used as a new therapeutic approach for the treatment of a variety of such malignancies. In the current study, we rationally designed two siRNA molecules to silence the cytotoxin‐associated gene A (CagA) and vacuolating cytotoxin A (VacA) genes of H. pylori for their significant involvement in developing cancer.MethodsWe selected a common region of all the available transcripts from different countries of CagA and VacA to design the siRNA molecules. The final siRNA candidate was selected based on the results from machine learning algorithms, off‐target similarity, and various thermodynamic properties.ResultFurther, we utilized molecular docking and all atom molecular dynamics (MD) simulations to assess the binding interactions of the designed siRNAs with the major components of the RNA‐induced silencing complex (RISC) and results revealed the ability of the designed siRNAs to interact with the proteins of RISC complex in comparable to those of the experimentally reported siRNAs.ConclusionThese designed siRNAs should effectively silence the CagA and VacA genes of H. pylori during siRNA mediated treatment in gastric cancer.

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Evaluation of <b><i>Helicobacter pylori</i></b> Genotypes in Obese Patients with Gastric Ulcer, Duodenal Ulcer, and Gastric Cancer: An Observational Study

Cited by 6 publications

References 30 publications

Dietary habits and Helicobacter pylori infection: is there an association?

Dietary habits and Helicobacter pylori infection: is there an association?

Celiac Disease: A Review from Genetic to Treatment

Gene silencing of Helicobacter pylori through newly designed siRNA convenes the treatment of gastric cancer

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