Outcomes for pregnant women infected with the influenza A (H1N1) virus during the 2009 pandemic in Porto Alegre, Brazil

Jimenez, Mirela Foresti; Beitune, Patrícia El; Salcedo, Mila Pontremoli; Ameln, Alexandra Veleda Von; Mastalir, Fabiane Pinto; Braun, Luciane Desimon

doi:10.1016/j.ijgo.2010.06.024

Cited by 21 publications

(28 citation statements)

References 10 publications

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“…Therefore, pregnant women infected with H1N1 can rapidly develop a hemodynamic imbalance, which acutely affects lung function and facilitates the development of pneumonia, acute pulmonary edema, and other serious respiratory illnesses; in addition, it reduces the ability of pregnant women to tolerate hypoxic stress, and increases maternal and perinatal mortality [15,16]. Studies of pregnant women infected with H1N1 during the 2009 pandemic reported an ICU admission rate ranging between 14% and 25%, which is consistent with the 22.6% observed in the present study [6,14,17].…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy

Figueiró-Filho

Oliveira²,

Pompílio³

et al. 2011

Intl J Gynecology & Obste

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Section: Discussionsupporting

confidence: 89%

“…However, a study of 57 pregnant Brazilian women hospitalized with H1N1 during the 2009 pandemic reported no cases of maternal death [17]. The main difference between these studies [14,17] and the present investigation is the rate of early initiation of antiviral treatment (64.5% in the present study vs 65.6% [14] and 80.7% [17]). …”

Section: Discussioncontrasting

confidence: 68%

Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy

Figueiró-Filho

Oliveira²,

Pompílio³

et al. 2011

Intl J Gynecology & Obste

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“…In a recent study in pregnant patients infected by the pH1N1 (2009) virus in Porto Alegre, no correlation was found between pregnancy or comorbidities and the risk of being admitted to the Intensive Care Unit (ICU); no viral loads were examined in the study [Jiménez et al, 2010]. Accordingly, no association between pregnancy and viral load, neither between pregnancy and death was found (data not shown).…”

Section: Discussionmentioning

confidence: 95%

Viral load and epidemiological profile of patients infected by pandemic influenza a (H1N1) 2009 and seasonal influenza a virus in Southern Brazil

Veiga

Filho

Corrêa

et al. 2012

Journal of Medical Virology

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Correlation between virologic profile and clinical features of patients infected by influenza virus provides important information for epidemiological control and clinical management of future disease outbreaks. Samples from patients in Southern Brazil, from June to December 2009, were examined and the viral load was correlated with epidemiological data. All samples were analyzed by qRT-PCR for detection of the 2009-pandemic Influenza A (H1N1). Relative viral loads were assessed based on the 2(-ΔCT) method and epidemiological data were obtained for each patient, following ethical policies. A total of 933 samples were positive for pH1N1 (2009) influenza; 172 were positive for seasonal influenza A; 13 were undetermined; 1992 samples were negative for influenza A. Combined molecular and epidemiological data were available for 38 seasonal and 198 pandemic samples. The median viral load was higher in pandemic than in seasonal influenza samples; in patients infected with pH1N1 (2009), viral load associated positively with chills, myalgia and rhinorrhea, and negatively with dyspnea, but no association was observed with other symptoms, nor with clinical conditions such as pregnancy, smoking, immunodepression and co-morbidities. Regarding patients infected with seasonal influenza, viral loads did not show statistically significant association with any of the symptoms. This is the first study in Brazil that examines epidemiological and molecular data from the 2009 influenza pandemic. The results may serve as a basis for developing strategies to control human-to-human infection and viral dissemination, and for implementing effective measures and public health policies against future novel disease outbreaks.

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“…Pregnant women were particularly severely affected by the 2009 H1N1 pandemic (H1N1pdm) virus [2][3][4][5][6][7] but their early treatment with antiviral agents seemed to be associated with fewer intensive care admissions and deaths [5]. Perinatal outcomes have been less investigated than maternal outcomes, however, in part because delivery had not yet occurred when earlier reports were published.…”

Section: Introductionmentioning

confidence: 99%

Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China

Jia

Suo

et al. 2011

International Journal of Gynecology & Obstetrics

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Outcomes for pregnant women infected with the influenza A (H1N1) virus during the 2009 pandemic in Porto Alegre, Brazil

Abstract: Neither an advanced pregnancy nor comorbidities increased the risk of being admitted to the ICU but, compared with the results of other studies, a prompt treatment lowered mortality.

Cited by 21 publications

References 10 publications

Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy

Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy

Viral load and epidemiological profile of patients infected by pandemic influenza a (H1N1) 2009 and seasonal influenza a virus in Southern Brazil

Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China

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