Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China

Du, Ming-Mei; Jia, Na; Suo, Jian; Xing, Yongzhong; Zhang, Pan-He; Liu, Gang; Xiao, Hong-Ju; Zhang, Jiu-Song; Jia, Ning; Gao, Yan; Xie, Ling; Deng, Chao; Shiwang, Ren; Liu, Yunxi

doi:10.1016/j.ijgo.2011.08.024

Cited by 8 publications

(12 citation statements)

References 18 publications

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“…In the present study, the most common clinical manifestations were similar to other studies (2,8). The prevalence of anemia was 88% in the present study, compared to 37% in the study by Jain et al, in the US (9), and 15.2% in another study in China (10). In our study, patients were merely pregnant women with H1N1 influenza, but the US study was conducted on the general population.…”

Section: Discussionsupporting

confidence: 89%

Pregnancy Outcomes Among Hospitalized Patients Infected With 2009 H1N1 Influenza Virus in Qom, Iran, in Oct-Nov. 2009

Jafarbegloo¹,

Tehrani²,

Tehran³

et al. 2013

Nurs Midwifery Stud

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Background: Pandemic H1N1 influenza A 2009 (H1N1/09) virus has been identified as a leading cause of febrile respiratory diseases worldwide, and pregnant women constitute a high risk group. Objectives: To determine the clinical characteristics and outcomes of pregnant women with H1N1 influenza A hospitalized in university hospitals of Qom city in Iran. Patients and Methods: This descriptive retrospective study was conducted using existed data related to October and November 2009. All pregnant women with influenza manifestations were admitted to the hospitals to undergo nasopharyngeal culture. H1N1 virus was confirmed in 11 cases. Data including demographic characteristics, clinical manifestations, laboratory test results, and pregnancy complications was extracted from medical records, and analyzed by descriptive statistics. Results: The mean age of the women was 28.1 ± 4.7 years with a mean gestational age of 28.7 ± 10.9 weeks. The most common clinical manifestations included coughing (100%), fever (87.5%), and dyspnea (75%). The most common abnormal test was anemia (88%). Pregnancy complications included preterm delivery (36.3%), low birth weight (18%), oligohydramnios (9%), gestational diabetes (9%), and fetal distress (9%). Also one (12.5%) wound dehiscence happened. Conclusions: vaccination seems to be necessary to prevent this potentially fatal infectious disease. Furthermore, timely prescription of antiviral medications is recommended to decrease the risk of severe complications.

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Section: Discussionsupporting

confidence: 89%

Pregnancy Outcomes Among Hospitalized Patients Infected With 2009 H1N1 Influenza Virus in Qom, Iran, in Oct-Nov. 2009

Jafarbegloo¹,

Tehrani²,

Tehran³

et al. 2013

Nurs Midwifery Stud

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“…The results are presented in Figure . In total, 100 studies were included in the review . Several studies provided data on maternal morbidity and mortality, pregnancy outcome and treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Data on pregnancy outcome were reported in 26 studies . In all studies, the effects of influenza A/H1N1 infection on pregnancy outcome were studied, except for the studies by Hansen et al.…”

Section: Resultsmentioning

confidence: 99%

Influenza virus infection in pregnancy: a review

Meijer

Noortwijk

Bruinse

et al. 2015

Acta Obstet Gynecol Scand

108

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“…A UK study reported an association between maternal influenza A(H1N1)pdm09 infection in pregnancy and increased risk of fetal death from 24 weeks [16], but the risk of diagnostic ascertainment bias for this study has been considered high [2]. In a Chinese study of maternal influenza A(H1N1)pdm09 infection in pregnancy, stillbirth was more frequent among women who tested positive for virus-specific antibodies compared to women who tested negative [17]. Furthermore, the risk of fetal death was increased following a primary-health-care diagnosis of influenza in pregnancy during the "swine flu" pandemic in 2009/2010 in Norway [18].…”

Section: Introductionmentioning

confidence: 83%

Seasonal and pandemic influenza during pregnancy and risk of fetal death: A Norwegian registry-based cohort study

et al. 2020

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Previous studies of fetal death with maternal influenza have been inconsistent. We explored the effect of maternal influenza-like illness (ILI) in pregnancy on the risk of fetal death, distinguishing between diagnoses during regular influenza seasons and the 2009/2010 pandemic and between trimesters of ILI. We used birth records from the Medical Birth Registry of Norway to identify fetal deaths after the first trimester in singleton pregnancies (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013). The Norwegian Directorate of Health provided dates of clinical influenza diagnoses by primary-health-care providers, whereas dates of laboratory-confirmed influenza A (H1N1) diagnoses were provided by the Norwegian Surveillance System for Communicable Diseases. We obtained dates and types of influenza vaccinations from the Norwegian Immunisation Registry. Cox proportional-hazards regression models were fitted to estimate hazard ratios (HRs) of fetal death, with associated 95% confidence intervals (CIs), comparing women with and without an ILI diagnosis in pregnancy. There were 2510 fetal deaths among 417,406 eligible pregnancies. ILI during regular seasons was not associated with increased risk of fetal death: adjusted HR = 0.90 (95% CI 0.64-1.27). In contrast, ILI during the pandemic was associated with substantially increased risk of fetal death, with an adjusted HR of 1.75 (95% CI 1.21-2.54). The risk was highest following firsttrimester ILI (adjusted HR = 2.28 [95% CI 1.45-3.59]). ILI during the pandemic-but not during regular seasons-was associated with increased risk of fetal death in the second and third trimester. The estimated effect was strongest with ILI in first trimester.

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Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China

Abstract: When left untreated, infection with the 2009 H1N1 pdm virus during pregnancy appears to have increased fetal mortality and morbidity. Because CAs are traumatic for all concerned, their possible association with the virus should be further evaluated.

Cited by 8 publications

References 18 publications

Pregnancy Outcomes Among Hospitalized Patients Infected With 2009 H1N1 Influenza Virus in Qom, Iran, in Oct-Nov. 2009

Pregnancy Outcomes Among Hospitalized Patients Infected With 2009 H1N1 Influenza Virus in Qom, Iran, in Oct-Nov. 2009

Influenza virus infection in pregnancy: a review

Seasonal and pandemic influenza during pregnancy and risk of fetal death: A Norwegian registry-based cohort study

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