Outcomes and Tolerance of Human Immunodeficiency Virus–Positive U.S. Veterans Undergoing Dose-Escalated External Beam Radiotherapy for Localized Prostate Cancer

Schreiber, David; Chhabra, Arpit; Rineer, Justin; Nabhani, T.; Katsoulakis, Evangelia; Morkos, Ramez; Rotman, Marvin; Schwartz, David L.

doi:10.1016/j.clgc.2013.07.008

Cited by 10 publications

(21 citation statements)

References 17 publications

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“…As reported in 7 studies, the average duration between HIV infection and PCa diagnosis ranged from 8.5-18.6 years (13,14,15,16,18,20,21). The majority of patients were on HAART at the time of PCa diagnosis (range, 69-100%) and the average CD4 count ranged from 336-523 cells/mm³.…”

Section: Patient Demographics and Characteristics Of Hiv Infectionmentioning

confidence: 84%

“…Three studies commented on follow-up PSA levels and found that 91% showed declining or stable PSA levels status post-RT treatment (19)(20)(21). The 4-or 5-year biochemical-failure free (BFF) rate was reported to be between 87-97% in 3 studies with a combined rate of 94.2% (13,16,17). This was comparable to the 89% and 85% BFF rate found in the HIV-negative control group in the study by Kahn et al and Ruden et al,respectively (13,17).…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 and 2 summarize the patient demographics and the characteristics of HIV infection, respectively. A total of 187 HIV-positive patients were included in 9 studies (13)(14)(15)(16)(17)(18)(19)(20)(21). Three articles, which notably have been published in the last 10 years, included a control arm with a total of 1 659 HIV-negative patients (13,15,17).…”

Section: Patient Demographics and Characteristics Of Hiv Infectionmentioning

confidence: 99%

“…Patient race was reported for 149 patients in 6 of the 9 studies: 118 (79%) African American, 21 (14%) White, 8 (5%) Hispanic, and 2 unknown (1.3%) (13,15,16,17,20,21). Of the 3 studies with a control group, Kahn et al and Ruden et al had matched controls (13,17).…”

Section: Patient Demographics and Characteristics Of Hiv Infectionmentioning

confidence: 99%

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Prostate Cancer Outcomes in Patients Living With HIV/AIDS Treated With Radiation Therapy: A Systematic Review

Vaziri¹,

Rao²,

Whalen³

et al. 2023

Advances in Radiation Oncology

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Section: Patient Demographics and Characteristics Of Hiv Infectionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Patient Demographics and Characteristics Of Hiv Infectionmentioning

confidence: 99%

Section: Patient Demographics and Characteristics Of Hiv Infectionmentioning

confidence: 99%

See 2 more Smart Citations

Prostate Cancer Outcomes in Patients Living With HIV/AIDS Treated With Radiation Therapy: A Systematic Review

Vaziri¹,

Rao²,

Whalen³

et al. 2023

Advances in Radiation Oncology

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“…The literature is largely limited to case series describing similar outcomes or tolerability of standard PCa treatments in men with HIV as the general population (10–16). In one of the largest reports, Pantanowitz et al .…”

Section: Introductionmentioning

confidence: 99%

Are HIV-Infected Men Vulnerable to Prostate Cancer Treatment Disparities?

Bhatia

Martin

Klein

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background HIV-infected (HIV+) men face cancer treatment disparities which impact outcome. Prostate cancer (PCa) treatment and treatment appropriateness in HIV+ men are unknown. Methods We used electronic chart review to conduct a retrospective cohort study of 43 HIV+ cases with PCa and 86 age- and race-matched HIV-uninfected (HIV−) controls with PCa, aged 40–79, from 2001–2012. We defined treatment appropriateness using National Comprehensive Cancer Network (NCCN) guidelines and the Charlson Co-morbidity Index (CCI) to estimate life expectancy. Results Median age was 59.5 years at PCa diagnosis. Median CD4+ T-cell count was 459.5cells/mm3, 95.3% received antiretroviral therapy, and 87.1% were virally suppressed. Radical prostatectomy (RP) was the primary treatment for 39.5% of HIV+ and 71.0% of HIV− men (p= 0.004). Only 16.3% of HIV+ vs. 57.0% of HIV− men received open RP (p< 0.001). HIV+ men received more radiotherapy (25.6% vs. 16.3%, p= 0.13). HIV was negatively associated with open RP (OR= 0.03, p= 0.007), adjusting for insurance and CCI. No men were undertreated. Fewer HIV+ men received appropriate treatment (89.2% vs. 100%, p= 0.003), due to 4 overtreated HIV+ men. Excluding AIDS from the CCI still resulted in fewer HIV+ men receiving appropriate treatment (94.6% vs. 100%, p = 0.03). Conclusion PCa in HIV+ men is largely appropriately treated. Under-or overtreatment may occur from difficulties in life expectancy estimation. HIV+ men may receive more radiotherapy and fewer RPs, specifically open RPs. Impact Research on HIV/AIDS survival indices and etiologies and outcomes of this PCa treatment disparity in HIV+ men is needed.

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Management of Localized Prostate Cancer in Men With Human Immunodeficiency Virus: Analysis of a Large Retrospective Cohort

Vaziri¹,

Rao²,

Whalen³

et al. 2023

Clinical Genitourinary Cancer

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Outcomes and Tolerance of Human Immunodeficiency Virus–Positive U.S. Veterans Undergoing Dose-Escalated External Beam Radiotherapy for Localized Prostate Cancer

Cited by 10 publications

References 17 publications

Prostate Cancer Outcomes in Patients Living With HIV/AIDS Treated With Radiation Therapy: A Systematic Review

Prostate Cancer Outcomes in Patients Living With HIV/AIDS Treated With Radiation Therapy: A Systematic Review

Are HIV-Infected Men Vulnerable to Prostate Cancer Treatment Disparities?

Management of Localized Prostate Cancer in Men With Human Immunodeficiency Virus: Analysis of a Large Retrospective Cohort

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