Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses: a multicenter study

Nandanan, Naveen; Veccia, Alessandro; Antonelli, Alessandro; Derweesh, Ithaar; Mottrie, Alexandre; Minervini, Andrea; Aron, Monish; Simone, Giuseppe; Capitanio, Umberto; Simeone, Claudio; Eun, Daniel; Perdonà, Sisto; Porter, James R.; Sundaram, Chandru P.; Zhang, Chao; Uzzo, Robert G.; Challacombe, Ben; Hampton, Lance J.; Kaouk, Jihad; Porpiglia, Francesco; Autorino, Riccardo

doi:10.5173/ceju.2020.0019

Cited by 4 publications

(2 citation statements)

References 33 publications

(27 reference statements)

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“…When discussing histopathologic outcomes of robotic PNs and RNs for renal masses, Nandanan et al 54 found benign histology altogether in 18% of cases and only 3% were managed with RN, while none of the patients underwent preoperative tumor biopsy. Using the Mayo Clinic Nephrectomy Registry, Kaushik et al 55 retrospectively identified 442 patients with unilateral sporadic benign renal masses referred to a tertiary care facility, and among them there were 206 treated with RN.…”

Section: Discussionmentioning

confidence: 99%

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Histopathologic Features of Kidney Tumors and Comparison of Patients Treated with Radical and Partial Nephrectomy at Osijek University Hospital Center from 2017 until the end of 2021

Sudarević

2023

ACC

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over a 5-year period and to compare the outcomes between patients treated with radical nephrectomy (RN) and partial nephrectomy (PN). From November 2016 until the end of 2021, there were 280 consecutive PNs and RNs included in this cross-sectional study. Exclusion criteria were nephrectomies due to non-oncologic reasons and transitional cell carcinoma. There were 229 RNs and 51 PNs, median age of all patients was 62.5 (range 34-84) years. In the RN group, there were 197 renal cell carcinomas (RCC), predominantly clear-cell subtype, while among others there were 8 multilocular cystic renal neoplasms of low malignant potential (MCRNLMP) and 6 oncocytomas and angiomyolipomas each. There were 44 RCCs, 4 oncocytomas, 1 MCRNLMP and 2 cysts removed with PN; median R.E.N.A.L. score was 5. RN group had greater tumor diameters and higher tumor grade, higher postoperative creatinine levels and complications of higher grade. There was no difference in median hospital stay (6 days) and follow-up (20 months). With regard to oncologic safety, preservation of kidney function and lower overall morbidity, PN should be preferred to RN whenever oncologically safe and technically feasible.

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Section: Discussionmentioning

confidence: 99%

“…When discussing histopathologic outcomes of robotic PNs and RNs for renal masses, Nandanan et al . ( 54 ) found benign histology altogether in 18% of cases and only 3% were managed with RN, while none of the patients underwent preoperative tumor biopsy. Using the Mayo Clinic Nephrectomy Registry, Kaushik et al .…”

Section: Discussionmentioning

confidence: 99%

Histopathologic Features of Kidney Tumors and Comparison of Patients Treated with Radical and Partial Nephrectomy at Osijek University Hospital Center from 2017 until the end of 2021

Sudarević

2023

ACC

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Pre-operative Serum Albumin as a Potential Predictor of Benign Lesions in Renal Masses

SEKITO¹,

Ogura²,

Soga³

et al. 2022

CDP

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Background/Aim: We investigated pre-operative factors for predicting whether renal masses are benign in order to facilitate the selection of optimal candidates for pre-operative biopsy. Patients and Methods: We evaluated 278 patients with renal masses suspected to be clinically T1 or T2 renal cell carcinoma. All patients had undergone a partial or radical nephrectomy. Pre-operative parameters, including patient characteristics, tumor size, and blood tests, were utilized to predict which lesions were benign. Results: Twenty-five lesions (9.0%) were benign. Multivariate analysis showed that female sex [odds ratio (OR)=2.92, p=0.016], serum albumin ≥4.3 g/dl (OR=3.50, p=0.013), and tumor size 23 mm (OR=3.96, p=0.002) were significant independent factors for benign renal masses. The incidence of benign lesions in cases with all three factors (female sex, higher serum albumin, and smaller tumor size) was 4 of 16 (25.0%), which was significantly higher (p=0.037) than that in all cases (25/278; 9.0%). Conclusion: Relatively high pre-operative serum albumin levels may be a predictor of benign lesions when associated with female sex and smaller tumor size.

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Risk Factors for Renal Function Impairment Following Radiofrequency Ablation of Renal Tumors

Park

Yoon

Kim

2022

J Korean Soc Radiol

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Purpose To evaluate the various factors that affect renal function following percutaneous radiofrequency ablation (RFA) therapy in patients with renal tumors. Materials and Methods Between 2010 and 2018, 91 patients diagnosed with renal tumors using ultrasonography and CT-guided RFA were enrolled. We retrospectively investigated the serum creatinine (SCr) level and estimated glomerular filtration rates immediately prior to RFA and during post-treatment follow-up. The patients were divided into two groups based on the degree of change in SCr level (0.3 mg/dL). Group comparisons were performed using univariable and multivariable logistic regression analyses to determine the factors impacting renal function. Results Impaired renal function was associated with solitary kidney, chronic kidney disease (CKD) over stage 3, and pyeloureteral injury. Sex, age, other cancers, tumor size, location, growth pattern, and proximity to the collecting system were not significantly associated with impaired renal function. There was a difference in the overall change over time between the association with and without solitary kidney, CKD stage 3, and pyeloureteral injury. Conclusion Among the medical conditions present prior to RFA, solitary kidney and CKD over stage 3 could be considered as risk factors for impaired renal function. Post-procedural pyeloureteral injury can also be considered a risk factor.

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Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses: a multicenter study

Cited by 4 publications

References 33 publications

Histopathologic Features of Kidney Tumors and Comparison of Patients Treated with Radical and Partial Nephrectomy at Osijek University Hospital Center from 2017 until the end of 2021

Histopathologic Features of Kidney Tumors and Comparison of Patients Treated with Radical and Partial Nephrectomy at Osijek University Hospital Center from 2017 until the end of 2021

Pre-operative Serum Albumin as a Potential Predictor of Benign Lesions in Renal Masses

Risk Factors for Renal Function Impairment Following Radiofrequency Ablation of Renal Tumors

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