Pre-operative Serum Albumin as a Potential Predictor of Benign Lesions in Renal Masses

Abstract

Background/Aim: We investigated pre-operative factors for predicting whether renal masses are benign in order to facilitate the selection of optimal candidates for pre-operative biopsy. Patients and Methods: We evaluated 278 patients with renal masses suspected to be clinically T1 or T2 renal cell carcinoma. All patients had undergone a partial or radical nephrectomy. Pre-operative parameters, including patient characteristics, tumor size, and blood tests, were utilized to predict which lesions were benign. Results: Twenty-five lesions (9.0%) were benign. Multivariate analysis showed that female sex [odds ratio (OR)=2.92, p=0.016], serum albumin ≥4.3 g/dl (OR=3.50, p=0.013), and tumor size 23 mm (OR=3.96, p=0.002) were significant independent factors for benign renal masses. The incidence of benign lesions in cases with all three factors (female sex, higher serum albumin, and smaller tumor size) was 4 of 16 (25.0%), which was significantly higher (p=0.037) than that in all cases (25/278; 9.0%). Conclusion: Relatively high pre-operative serum albumin levels may be a predictor of benign lesions when associated with female sex and smaller tumor size.

Investigation of the Rate of Benign Histology and Related Factors in Clinical Stage T1 Kidney Tumors Tİtle

“…Sekito et al investigated pre-operative factors for predicting whether renal masses are benign (20). Their study included 278 patients with renal masses who had undergone a partial or radical nephrectomy for clinically suspected T1 or T2 renal cell carcinoma.…”