Outcomes after radiotherapy for squamous cell carcinoma of the eyelid

Abstract

BACKGROUND. Squamous cell carcinoma (SCC) of the eyelid is a rare malignancy with metastatic potential. In the current study, the outcomes of patients with SCC of the eyelid were evaluated after definitive and postoperative radiation therapy. METHODS. The medical records of all patients treated with radiotherapy for SCC of the eyelid at 1 institution between 1950 and 2005 were reviewed. Patient records were analyzed for clinical characteristics, pathologic features, radiation techniques, and outcomes. Survival rates were calculated using the Kaplan‐Meier method; factors affecting survival were assessed using the log‐rank test. RESULTS. During the study period, 39 patients with 42 eyelid SCCs were treated with radiotherapy. Thirty‐two tumors were treated with primary radiotherapy and 10 were treated with postoperative radiotherapy after wide local excision. Surviving patients were followed for a median of 76 months. The 5‐year disease‐specific and overall survival rates for all patients were 86% and 71%, respectively. At 5 years, local, regional, and distant disease control rates for all tumors were 88%, 95%, and 97%, respectively. There were no significant differences in the 5‐year local, regional, and distant control rates between tumors treated with definitive and those treated with postoperative radiotherapy. There were no grade 3 or 4 complications. CONCLUSIONS. Primary radiotherapy for SCC of the eyelid provides excellent locoregional control with reasonable complication rates and should be considered an alternative to surgery in selected patients. Cancer 2008. © 2007 American Cancer Society.

Beta therapy with 90strontium as single modality therapy for canine squamous cell carcinoma in third eyelid

“…Schirmer Tear Test (STT-1) before and after treatment was of 13.7±2.1 mm/min and 12.8±1.97mm min -1 , respectively. Cytological preparations from impression smears and tissue scrapings can be of limited diagnostic value in many conditions (PETSUKSIRI et al, 2008), but exfoliative cytology allowed the diagnosis of SCC of the third eyelid in all dogs in the present report. Biopsies and exfoliative cytology have been also used in the diagnosis of corneolimbal SCC in horses (REBHUN, 1998).…”

“…The recurrence rate among patients of this study was low, suggesting that topical beta-radiation can be an effective treatment modality for SCC of the third eyelid in dogs, similarly to conjunctival carcinoma in human patients (CEREZO et al, 1990). Petsuksiri et al (2008) related the primary radiotherapy for SCC of the eyelid in human patients, and the report concluded that the radiotherapy provides excellent locoregional control with reasonable complications rates and should be considered an alternative to surgery in selected patients. The non-invasive nature of the procedure described here when compared to surgical excision may prove to be a great advantage of radiation.…”

“…Biopsies and exfoliative cytology have been also used in the diagnosis of corneolimbal SCC in horses (REBHUN, 1998). Fine-needle aspirates may be difficult to perform safely at this site unless the patient is anesthetized, and many find it preferable to collect a total excisional biopsy of the lesion once the patient is under general anesthesia (PETSUKSIRI et al, 2008). Excisional biopsy, however, would have compromised the main objective of this study, which was to observe the effects of beta therapy ( 90 Sr) as a single modality of treatment, avoiding surgery.…”

Interstitial high-dose-rate brachytherapy in eyelid cancer

“…Sequelae are usually more pronounced for larger tumors, high total dose, larger fractionated dose, or higher dose rate (2,32). However, in HDR BT, the total dose is usually divided over a few sessions to avoid damage to surrounding normal tissue (31e34), and radiation doses and fractionation were not found to be significantly correlated with long-term complications in previous studies (35).…”

Utilization of a 3D printer to fabricate boluses used for electron therapy of skin lesions of the eye canthi

“…Such a bolus increases skin dose, homogenizes dose heterogeneity resulting from the irregular skin surface, and protects distal tissues by conforming dose line to the distal PTV surface 9. Similarly, bolus electron conformal therapy (ECT) has been shown clinically useful for many clinical sites10 such as chest wall irradiation (postmastectomy irradiation),11, 12, 13 head and neck radiotherapy,14, 15, 16, 17, 18, 19, 20, 21, 22, 23 paraspinal muscle region,24 and extremities 25…”