Outcomes After Intravesical Bacillus Calmette-Guerin Are Not Affected by Substaging of High Grade T1 Transitional Cell Carcinoma

Kondylis, Filippos I.; Demirci, Salim; Ladaga, Leopold E.; Kolm, Paul; &NA;, P. F. SCHELLHAMMER

doi:10.1097/00005392-200004000-00013

Cited by 5 publications

(10 citation statements)

References 17 publications

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“…The depth of lamina propria invasion has been significant in multivariable analyses for overall survival in three studies using the substaging system based on MM identification [9,16,21]. Recurrence rates and recurrence-free intervals did not differ significantly for either group in our study, which was also in agreement with the results published previously [7,8,18,24,25,28]. …”

Section: Discussionsupporting

confidence: 92%

“…A second proposal divides T1 patients into two populations only. Tumours superficial to the MM or reaching the MM but not passing through it were classified as pT1a, and tumours passing through the MM and invading the submucosa were considered to be pT1b [16,21,24]. A third proposal subclassifies T1 tumours as either with MM invasion (pT1b) or without (pT1a) [6,7,17,20,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Retrospective analysis of archived T1 tumour samples was used in the majority of published studies [5,6,7,8,16,17,18,19,20,21,22,23,24,25,27,28]. In our present study, the evaluation of the depth of tumour invasion was done prospectively immediately after the TUR by several pathologists as part of the routine pathological report.…”

Section: Discussionmentioning

confidence: 99%

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The Prognostic Value of T1 Bladder Cancer Substaging: A Single Institution Retrospective Study

Soukup¹,

Dušková

Pešl³

et al. 2014

Urol Int

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Objective: To evaluate the prognostic value of the depth of lamina propria invasion in patients with T1 bladder cancer. Subjects and Methods: 200 patients were treated between the years 2002 and 2009. Tumours with depth of invasion above the muscularis mucosae level were categorised as pT1a and those with depth of invasion up to or beyond the muscularis mucosae as pT1b. Results: Categorisation for pT1a and pT1b was performed in 176 of 200 patients (88%). In 10 patients a muscle-invasive tumour was found in re-transurethral resection samples. 131 (79%) of 166 analysed patients had pT1a tumour and 35 (21%) had pT1b tumour. During the follow-up, in 101 (61%) patients the tumour had recurred and in 27 (16.3%) the tumour had progressed. Of all the investigated parameters, T1 substaging (p < 0.0001), grade (p = 0.0003) and the number of bacillus Calmette-Guérin instillations (p = 0.0490) were significant in predicting progression. The only significant factor for disease-specific survival was T1 substaging in univariable (p = 0.0008) and multivariable (hazard ratio 4.407) analysis. T1 substaging (p = 0.0149) and tumour multiplicity (p = 0.0448) have a statistically significant prognostic value with respect to overall survival. Conclusions: Deep invasion of the lamina propria is a significant adverse prognostic factor for tumour progression, disease-specific survival and overall survival.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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The Prognostic Value of T1 Bladder Cancer Substaging: A Single Institution Retrospective Study

Soukup¹,

Dušková

Pešl³

et al. 2014

Urol Int

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“…Similarly, Kondylis et al . found no significant difference in recurrence and progression in their study, with a median follow‐up of 71 months . Conversely, in the largest of these studies, involving 587 pT1 patients from six hospitals and median follow‐up of 35 months, Rouprêt et al .…”

Section: Stage Pt1 Carcinomamentioning

confidence: 82%

“…Furthermore, the location of the vascular plexus can vary greatly either above or below the muscularis mucosae, particularly in the trigone, making the use of the vascular plexus questionable . Nonetheless, beginning in 1990 with Younes et al ., many studies have investigated pT1 substaging relative to the muscularis mucosae and/or vascular plexus with mixed, but generally positive, results …”

Section: Stage Pt1 Carcinomamentioning

confidence: 99%

Staging of bladder cancer

et al. 2018

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Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.

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Prognostic value of histopathological tumour growth patterns at the invasion front of T1G3 urothelial carcinoma of the bladder

Denzinger

Burger²,

Fritsche³

et al. 2009

Scandinavian Journal of Urology and Nephrology

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Outcomes After Intravesical Bacillus Calmette-Guerin Are Not Affected by Substaging of High Grade T1 Transitional Cell Carcinoma

Abstract: Substaging of T1 tumors did not affect response to BCG in regard to recurrence or progression. Therefore, intravesical BCG is effective for stages T1a and T1b disease.

Cited by 5 publications

References 17 publications

The Prognostic Value of T1 Bladder Cancer Substaging: A Single Institution Retrospective Study

The Prognostic Value of T1 Bladder Cancer Substaging: A Single Institution Retrospective Study

Staging of bladder cancer

Prognostic value of histopathological tumour growth patterns at the invasion front of T1G3 urothelial carcinoma of the bladder

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