Outcome Results of Transurethral Collagen Injection for Female Stress Incontinence: : Assessment by Urinary Incontinence Score

Groutz, Asnat; Blaivas, Jerry G.; Kesler, Stuart; Weiss, Jeffrey P.; Chaikin, David C.

doi:10.1016/s0022-5347(05)66940-6

Cited by 48 publications

(22 citation statements)

References 13 publications

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“…Unfortunately, the results reported from clinical trials remain poorly comparable, even with identical agents; differing methods of assessing success significantly affect the ability to compare studies. Strict outcome criteria may lead to a report of poorer outcomes, such as the 60% fair-to-poor results reported with Contigen by Groutz et al [7]. Alternatively, results gleaned from retrospective chart reviews and telephone interviews may led to more favorable reporting;…”

Section: Currently Available Agentsmentioning

confidence: 99%

Injectable agents: Present and future

et al. 2002

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Stress urinary incontinence (SUI) is primarily managed by conservative strategies. When these methods fail, minimally invasive treatments, if effective, safe, and durable, can result in a considerable reduction in current medical costs for this common condition. Injection of currently available bulking agents is a safe, minimally invasive procedure and offers a degree of efficacy. The long-term durability of several of these agents is yet to be determined. The use of bulking agents for the treatment of anatomic SUI has been demonstrated to produce success rates similar to those observed when these materials are used in patients with intrinsic sphincter deficiency, opening up new therapeutic options for women with SUI. We review the current basic science and clinical research into the development of newer agents for soft-tissue bulking.

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Section: Currently Available Agentsmentioning

confidence: 99%

Injectable agents: Present and future

et al. 2002

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“…However, the long-term efficacy and durability of this therapy has been questioned with repeat procedures required in a high number of patients. 3 Previous reports have suggested that vaginal or retropubic suspension procedures for stress incontinence in the elderly population have a variable rate of success. 4 -6 In 1993 it was proposed that a mid urethral tape could reinforce the pubourethral ligaments and help restore continence.…”

mentioning

confidence: 99%

The Influence of Age on Quality of Life Outcome in Women Following a Tension-Free Vaginal Tape Procedure

et al. 2004

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“…As a re sult, whi le 13% of the pa ti ents had to tal cu re, the symptoms im pro ved in 27% of them. 12 In another study, in which collagen was utilized again, negative stress test was detected only in 10, 3% (19 patients) of the patients out of 184 cases that were monitored along 3 years. 13 Furt her mo re, col la gen may ca u se de la yed type hyper sen si ti vity re ac ti on and art hral gi a.…”

Section: Discussionmentioning

confidence: 95%

Effectiveness of Periurethral Injection on Stress Urinary Incontinence

Güngören¹,

Dolapçıoğlu²,

Hakverdi³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : To determine one-year subjective and objective evaluation results of periurethral injection (PUI) applied to women suffering from stress urinary incontinence (SUI). M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: Twenty five patients with complaints of SUI have participated in our study. Preoperative and postoperative results of urinalysis, stress and Q-tip tests, post voiding residual volumes (RV) and survey of incontinence quality of life (I-QOL) criteria were recorded. Later on, Urodex ® (Cross-linked hyaluronic acid, detxranomere) was injected to them. The cases were monitored at regular intervals for a mean of 14 ± 5.84 months. R Re es su ul lt ts s: : Eighteen (72%) out of all cases were encountered during menopausal period. Eight of the patients had previous gynecologic operations. Mean age was 53.97 ± 13.01 years. Mean application period of PUI was 6.95 ± 1.46 minutes. Differences between the preoperative and postoperative results of RV and I-QOL were not statistically significant. From subjective success point of view; 17 (68%) of the patients claimed no change on their incontinence problem, two (8%) of the patients claimed that their conditions were slightly improved, and six (24%) of the patients claimed that their conditions significantly improved. When objective success is considered, there was success in seven (28%) patients, and failure in 18 (72%) patients. C Co on nc cl lu us si io on n: : PUI is a minimally invasive treatment method used in all types of SUI. PUI treatment might be preferred for the old, obese patients with additional health problems, having incontinence dependent on hypermobility at which the open surgery incurs a great risk. However, as the new techniques are not readily available, a periurethral injection technique may still be a valid choice in patients who have poor surgical risks, and to whom the low success rate has been adequately explained.K Ke ey y W Wo or rd ds s: : Urinary incontinence, stress; urinary bladder neck obstruction Ö ÖZ ZE ET T A Am ma aç ç: : Stres üriner inkontinansı (SUI) kadınlarda uygulanan periüretral enjeksiyonun (PUI) sonuçlarının subjektif ve objektif olarak değerlendirilmesi. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: SUI nedeniyle başvuran 25 hasta çalışmaya alındı. Preoperatif ve postoperatif olarak idrar tetkiki, stres ve Q-tip testleri, post-voiding rezidü volümleri (RV) ve inkontinans yaşam kalitesi anket (I-QOL) ölçümleri incelendi. Daha sonra bu hastalarda Urodex ® (Cross-linked hyaluronic acid, dekstranomere) enjeksiyonu uygulandı. Hastalar ortalama 14 ± 5.84 ay süresince düzenli aralıklarla izlendi. B Bu ul l g gu u --l la ar r: Tüm olguların 18'i (%72) menopozal dönemde çalışmaya alınmıştı. Hastaların sekizi daha önceden jinekolojik operasyon geçirmişti. Yaş ortalaması 53.97 ± 13.01 idi. Ortalama PUI uygulama süresi 6.95 ± 1.46 dk. idi. Preoperatif ve postoperatif dönemdeki RV ve I-QOL arasında anlamlı farklılık gözlenmedi. Subjektif yarar açısından b...

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Outcome Results of Transurethral Collagen Injection for Female Stress Incontinence: : Assessment by Urinary Incontinence Score

Abstract: As defined by strict subjective and objective criteria, we noted a low short-term cure rate after collagen injection in women with severe sphincteric incontinence. It remains to be determined how patients with less severe incontinence would fare using our outcome assessment instruments.

Cited by 48 publications

References 13 publications

Injectable agents: Present and future

Injectable agents: Present and future

The Influence of Age on Quality of Life Outcome in Women Following a Tension-Free Vaginal Tape Procedure

Effectiveness of Periurethral Injection on Stress Urinary Incontinence

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