Outcome of Post Induction Therapy for Acute Myeloid Leukemia in Nanakaly Hospital-Erbil

Abstract

Background: Acute myeloid leukaemia in adult constitutes 80% of whole acute leukaemia cases; its frequency progressively increases with age. Objective: To evaluation the parameters of AML patients clinically and haematologically in Erbil City. Patients and Methods: A particular analysis of hospital records retrospective study of 29 patients with AML was taken on. The cases were analyzed and achieved at Nanakaly hospital in Erbil city during the years 20021-2022. Diagnosis was established on peripheral blood and bone marrow reports. The myeloid origin confirmation was concerned by cytochemistry, morphological subtyping was concerned according to the (FAB) criteria, biochemical tests, and cluster CDs was done by flowcytometery. Microsoft excel version 2010 and (GraphPad Prism 9.0.) was in employment for carrying out statistical analysis. Results: This study included 18 males and 11 females. Their ages ranged from 5 and 80 years with a mean age of 38.4 years. CD13 and CD33 are most expressed CD markers (75% and 70% respectively). CD22 and TdT lowest expressed CDs (10% and 5% respectively). Depending on the complete remission/Partial remission association, the p-value of platelets was significant (0.0207), CD64 and CD117 showed greater significant (<0.0001, <0.0001 respectively), BM hypercellularity fragments (P=0.0068), trials (P<0.0001), and blast percentage (P=0.0365). Conclusion: CDs and BM results are essential tools in the identification of AML. CD13 and CD33 are the most frequent CDs in this study. Morphologic valuation of BM was statistically significant, cellularity of BM and blast percentage was significantly correlated with post induction response in patients with AML. Keywords: Acute Myeloblastic Leukemia, Immunophenotyping, bone marrow reports, Flow Cytometry and CD Markers