Outcome of Multipair Donor Kidney Exchange by a Web-Based Algorithm

Abstract

Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP).

Paired and Altruistic Kidney Donation in the UK

“…In the case of the rows corresponding to the numbers of altruistic donors, identified short chains and actual short chains, we consider 2012 data only (as altruistic donors were only introduced into the NLDKSS from January 2012) when computing these values. The maximum number of identified transplants (36) arose in the January 2011 matching run, with the maximum number of actual transplants (22) coming from the October 2012 run. In general not all transplants identified by the software will lead to operations in practice: one reason is that more detailed cross-matching between each donor and recipient identified for transplant takes place after the matching run, which may lead to new incompatibilities being identified; also a donor or recipient may become ill between the date of the matching run and the date of the operation.…”

“…However we remark here that the optimality definition given in Definition 1 as agreed by the Kidney Advisory Group of NHSBT is primarily driven by clinical considerations. We also point out that the Netherlands [19] and South Korea [22] employ multi-objective lexicographic optimization, as in our case.…”

“…Within the last decade, kidney exchange has received considerable attention in the computer science and operations research [1,2,3,6,8,10,11,13,15,16,17,32,40], economics [4,7,34,35,36,41] and medical [5,12,18,20,21,22,23,25,26,29,30,33,37,38,39] literature, with many of these papers being inter-disciplinary in nature. It has been observed that when only pairwise exchanges are permitted, an optimal solution can usually (depending of course on the definition of optimality) be found in polynomial time using maximum weight matching in a general graph (see e.g., [10] for more details).…”

Clinical Outcomes of Multicenter Domino Kidney Paired Donation

“…DRPs has therefore become exponentially more complicated (7,(9)(10)(11). However, a significant proportion of the incompatible DRPs participating in such programs could remain unmatched (11)(12)(13).…”

“…However, a significant proportion of the incompatible DRPs participating in such programs could remain unmatched (11)(12)(13). (14).…”