Abstract:Domino kidney paired donation (KPD) is a method by which an altruistic living nondirected donor (LND) isOne-year and 5-year graft survival rates were 98.3% and 87.7%, respectively, with a median followup of 46 months. One-year and 5-year patient survival rates were 97.2% and 90.8%, respectively. In conclusion, multicenter domino KPD could multiply the benefits of donation from LNDs, with patients and graft survival rates comparable to those seen with conventional KPD.
“…The South Korean and Dutch groups have reported only domino chains that had no bridge donors and were designed to be kept short to avoid potential reneges. Additionally, their donors traveled to the recipients centers rather than the grafts being shipped (16,23).…”
Section: Discussionmentioning
confidence: 99%
“…Simulations from the United States and reports from Korea and the Netherlands have not fully addressed these concerns (3,16,17). We report the experience of the first 54 chains involving 272 kidney transplants that were orchestrated by a multicenter registry using an exhaustive search algorithm to identify potential matches.…”
We report the results of a large series of chain transplantations that were facilitated by a multicenter US database in which 57 centers pooled incompatible donor/recipient pairs. Chains, initiated by nondirected donors, were identified using a computer algorithm incorporating virtual cross-matches and potential to extend chains. The first 54 chains facilitated 272 kidney transplants (mean chain length = 5.0). Seven chains ended because potential donors became unavailable to donate after their recipient received a kidney; however, every recipient whose intended donor donated was transplanted. The remaining 47 chains were eventually closed by having the last donor donate to the waiting list. Of the 272 chain recipients 46% were ethnic minorities and 63% of grafts were shipped from other centers. The number of blood type O-patients receiving a transplant (n = 90) was greater than the number of blood type O-non-directed donors (n = 32) initiating chains. We have 1-year follow up on the first 100 transplants. The mean 1-year creatinine of the first 100 transplants from this series was 1.3 mg/dL. Chain transplantation enables many recipients with immunologically incompatible donors to be transplanted with high quality grafts.
“…The South Korean and Dutch groups have reported only domino chains that had no bridge donors and were designed to be kept short to avoid potential reneges. Additionally, their donors traveled to the recipients centers rather than the grafts being shipped (16,23).…”
Section: Discussionmentioning
confidence: 99%
“…Simulations from the United States and reports from Korea and the Netherlands have not fully addressed these concerns (3,16,17). We report the experience of the first 54 chains involving 272 kidney transplants that were orchestrated by a multicenter registry using an exhaustive search algorithm to identify potential matches.…”
We report the results of a large series of chain transplantations that were facilitated by a multicenter US database in which 57 centers pooled incompatible donor/recipient pairs. Chains, initiated by nondirected donors, were identified using a computer algorithm incorporating virtual cross-matches and potential to extend chains. The first 54 chains facilitated 272 kidney transplants (mean chain length = 5.0). Seven chains ended because potential donors became unavailable to donate after their recipient received a kidney; however, every recipient whose intended donor donated was transplanted. The remaining 47 chains were eventually closed by having the last donor donate to the waiting list. Of the 272 chain recipients 46% were ethnic minorities and 63% of grafts were shipped from other centers. The number of blood type O-patients receiving a transplant (n = 90) was greater than the number of blood type O-non-directed donors (n = 32) initiating chains. We have 1-year follow up on the first 100 transplants. The mean 1-year creatinine of the first 100 transplants from this series was 1.3 mg/dL. Chain transplantation enables many recipients with immunologically incompatible donors to be transplanted with high quality grafts.
“…The median wait time between enrollment and transplantation was 13 months. Oneyear and 5-year graft survival rates were 98.3 % and 87.7 %, respectively, with a median follow-up of 46 months [33].…”
Section: South Koreamentioning
confidence: 94%
“…16 centres participated and between 2001 and 2007; 179 transplants were performed with 70 domino chains initiated by NDD. The mean age of NDD was 43.7±8.8 (range, 37-50 years), with many (28 %) in a religious profession [33]. In addition, there were 45 two-pair chains, 15 three-pair chains, 7 four-pair chains, 2 five-pair chains and 1 six-pair chain.…”
Approximately one-third of kidney transplant candidates have medically acceptable living donors, but are unable to receive transplants due to donor-recipient incompatibilities. Kidney paired donation (KPD) is a strategy that matches incompatible pairs in order to find compatible matches, thus increasing living donor transplantation. The concept was first conceived in 1986. Since then, significant strides have been made. However, the technique remains underutilized. This article describes the current advances, types of paired donation programmes, registries, worldwide experience, outcomes, barriers, and limitations.
“…In practice, individuals who donate to a stranger often express dissatisfaction or discomfort with the term 'Good Samaritan'. There is also mixed evidence regarding religion as a driving force behind donation to a stranger (6,9,12,(18)(19)(20). In most religions, organ donation during life is considered a supremely generous and ennobling act (21,22).…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citationsâcitations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.