Outcome of infants from mothers with anti-SSA/Ro antibodies

Motta, Mario; Rodriguez‐Pérez, Carmen; Tincani, Anǵela; Lojacono, Andrea; Chirico, G

doi:10.1038/sj.jp.7211688

Cited by 39 publications

(21 citation statements)

References 32 publications

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“…ICAVB commonly occurs in children born to mothers with systemic lupus erythematosus. 8,16,[23][24][25] It has been demonstrated that neonates of Ab ϩ mothers have a much higher rate of both atrioventricular block and organic heart disease than those born to Ab Ϫ mothers, suggesting that an immunemediated process may lead to worse outcomes. 24,25 In another study, 12 infants born to Ab ϩ mothers had deterioration in cardiac and clinical status 3.7 to 9.3 years after diagnosis of ICAVB.…”

Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Right Ventricular Pacing in Young Adults With Structurally Normal Heart

et al. 2010

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Background-Right ventricular pacing increases the risk of heart failure in adults with structural heart disease. The impact of prolonged right ventricular pacing in adults without structural heart disease is not fully characterized and may depend on interactions of pacing with abnormal substrate predisposing to ventricular dysfunction. Methods and Results-We assessed the effect of right ventricular pacing in patients who underwent pacemaker implantation for isolated congenital atrioventricular block between 1964 and 2005. To assess for immunologic contribution to cardiac dysfunction, outcomes were compared between patients with (Ab ϩ ) and without (Ab Ϫ ) antinuclear antibody during adulthood and an age-and sex-matched Olmsted County, Minnesota, population. Of 103 patients (meanϮSD age, 32Ϯ19 years), 18 were Ab

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Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Right Ventricular Pacing in Young Adults With Structurally Normal Heart

et al. 2010

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“…Maternal antibodies are passed without regard to their specificity, meaning that both protective and autoantibodies have equal access to the developing fetus. Maternal autoantibodies can cause pathology in the neonate, which may be transient (in the case of myasthenia gravis) [68] or permanent, as in the case of SLE [69]. …”

Section: Immune Findings In Families Of Individuals With Asdmentioning

confidence: 99%

The immune system's role in the biology of autism

Goines

Water

2010

Current Opinion in Neurology

214

147

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PURPOSE OF REVIEW The following is a review of the most recent research concerning the potential role of immune system dysfunction in autism. This body of literature has expanded dramatically over the past few years as researchers continue to identify immune anomalies in individuals with autism. RECENT FINDINGS The most exciting of these recent findings is the discovery of autoantibodies targeting brain proteins in both children with autism and their mothers. In particular, circulating maternal autoantibodies directed towards fetal brain proteins are highly specific for autism. This finding has great potential as a biomarker for disease risk, and may provide an avenue for future therapeutics and prevention. Additionally, data concerning the cellular immune system in children with autism suggest there may be a defect in signaling pathways that are shared by the immune and central nervous systems. While studies to explore this hypothesis are ongoing, there is great interest in the commonalities between the neural and immune systems and their extensive interactions. SUMMARY In summary, there is exciting research regarding the role of the immune system in autism spectrum disorders that may have profound implications for diagnosis and treatment of this devastating disease.

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“…Either Costedoat-Chalumeau et al [26] in a large study in about 140 children aged 0 to 2 months (58 anti-Ro ⁄ SSA positive) born from CTD mothers, and Gerosa et al [27] who prospectively followed 60 antiRo ⁄ SSA-positive and 36 negative newborns throughout the first year of life did not find any significant difference in the QTc interval duration between the two groups. However, in an another Italian prospective study on 51 versus 50 infants born from anti-Ro ⁄ SSA-positive and negative CTD mothers, respectively, the author reported a mean QTc value slightly longer (approaching the statistical significance: P = 0.060) in positive subjects than in controls [28]. Moreover, Gordon et al [29] demonstrated the existence of an increased mean QTc in children from anti-Ro ⁄ SSA-positive mothers, with a further increase in those with siblings with CHB, with respect to children from anti-Ro ⁄ SSA-negative mothers with CTD.…”

Section: Pathogenetic Mechanismsmentioning

confidence: 99%

“…In fact, the systematic ECG evaluation at birth in newborns from anti-Ro ⁄ SSA-positive mothers revealed that also CHB of first or second degree develops in a significant number of subjects [27,28,56]. Moreover, by using Doppler echocardiographic methods or tissue velocity-based foetal kinetocardiogram, different authors demonstrated that quite frequently (up to one-third of the cases) foetuses from anti-Ro ⁄ SSA-positive mother have signs of first (or second) degree AV block, in most cases normalizing spontaneously or after maternal treatment with fluorinated steroids, before or early after delivery [57,58].…”

Section: Authorsmentioning

confidence: 99%

Anti-Ro/SSA Antibodies and Cardiac Arrhythmias in the Adult: Facts and Hypotheses

Lazzerini

Capecchi

Laghi-Pasini

2010

Scandinavian Journal of Immunology

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It is well established that the passive trans‐placental passage of anti‐Ro/SSA antibodies from mother to foetus is associated with the risk to develop an uncommon syndrome named neonatal lupus (NLE), where the congenital heart block represents the most severe clinical feature. Recent evidence demonstrated that also adult heart, classically considered invulnerable to the anti‐Ro/SSA antibodies, may represent a target of the arrhythmogenicity of these autoantibodies. In particular, the prolongation of the QTc interval appears the most frequent abnormality observed in adults with circulating anti‐Ro/SSA antibodies, with some data suggesting an association with an increased risk of ventricular arrhythmias, also life threatening. Moreover, even though the association between anti‐Ro/SSA antibodies and conduction disturbances is undoubtedly less evident in adults than in infants, from the accurate dissection of the literature data the possibility arises that sometimes also the adult cardiac conduction tissue may be affected by such antibodies. The exact arrhythmogenic mechanisms involved in foetus/newborns and adults, respectively, have not been completely clarified as yet. However, increasing evidence suggests that anti‐Ro/SSA antibodies may trigger rhythm disturbances through an inhibiting cross‐reaction with several cardiac ionic channels, particularly the calcium channels (L‐type and T‐type), but also the potassium channel hERG, whose different expression and involvement in the cardiac electrophysiology during lifespan might account for the occurrence of age‐related differences.

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Outcome of infants from mothers with anti-SSA/Ro antibodies

Cited by 39 publications

References 32 publications

Effect of Long-Term Right Ventricular Pacing in Young Adults With Structurally Normal Heart

Effect of Long-Term Right Ventricular Pacing in Young Adults With Structurally Normal Heart

The immune system's role in the biology of autism

Anti-Ro/SSA Antibodies and Cardiac Arrhythmias in the Adult: Facts and Hypotheses

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