Effect of Long-Term Right Ventricular Pacing in Young Adults With Structurally Normal Heart

Sagar, Sandeep; Shen, Win Kuang; Asirvatham, Samuel J.; Mei, Yong; Espinosa, Raúl E.; Friedman, Paul A.; Hodge, David O.; Munger, Thomas M.; Porter, Co Burn J.; Rea, Robert F.; Hayes, David L.; Jahangir, Arshad

doi:10.1161/circulationaha.109.866343

Cited by 50 publications

(27 citation statements)

References 32 publications

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“…In addition, the presence of left ventricular dysfunction has been reported as an independent predictor of a deleterious clinical impact of PPI, 32,33 whereas LVEF remained stable over time in most patients without structural heart disease receiving a PPI. 34 However, we did not find differences between patients with and without PPI when analyzing the data by subgroups according to left ventricular function. The severity of comorbidities and concomitant structural heart disease in patients undergoing TAVI led to a high rate of death and heart failure, and this might mitigate the potential negative effect of PPI in these patients.…”

Section: Ppi After Tavi and Clinical Outcomescontrasting

confidence: 55%

Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation

et al. 2014

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T ranscatheter aortic valve implantation (TAVI) has become the treatment of choice for patients with aortic stenosis who are considered to be nonoperable and a good alternative for those at high surgical risk.1 However, the occurrence of some periprocedural complications remains a concern. The need for permanent pacemaker implantation (PPI) after the procedure is one of the most frequent complications associated with TAVI, with an overall incidence of ≈15% (≈25% and 7% after TAVI with self-expandable valves [SEVs] and balloon-expandable valves [BEVs], respectively). 1 Clinical Perspective on p 1243Strong evidence supports the potential negative impact of right ventricular apical pacing, which has been associated with an increased rate of the combined end point of mortality and rehospitalization for heart failure in patients with left ventricular dysfunction, 2-4 ventricular tachyarrhythmias, 5,6 and pacing-induced cardiomyopathy in patients without overt structural heart disease. 7 However, evidence for the clinical impact of PPI after TAVI remains scarce and based on small Background-Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients. =0.121). Conclusions-The need for PPI was a frequent complication of transcatheter aortic valve implantation, but it was not associated with any increase in overall or cardiovascular death or rehospitalization for heart failure after a mean follow-up of ≈2 years. Indeed, 30-day PPI was a protective factor for the occurrence of unexpected (sudden or unknown) death.

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Section: Ppi After Tavi and Clinical Outcomescontrasting

confidence: 55%

Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation

et al. 2014

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“…It should be highlighted that not all patients develop LV dyssynchrony and newonset heart failure after RV pacing. Therefore, early predictive factors (Zhanget al, 2008;Siu et al,2008 ;Sagar et al, 2010), such as dyssynchrony at the time of implantation, paced QRS width, age, presence of atrial fibrillation, concomitant coronary artery disease, or compromised LVEF, or antibody status should be further evaluated, they may reveal the patients who are more prone to LV function deterioration and who are consequently better candidates for biventricular pacing. CRT use with milder degrees of LV dysfunction or even normal cardiac function as a means of maintaining cardiac mechanical synchrony is at this date, controversial.…”

Section: Resultsmentioning

confidence: 99%

Permanent Cardiac Pacing in Adults with High Grade Atriovetricular Block and Preserved Left Ventricular Function: Optimal Mode and Site of Pacing

Ouali¹

2011

Cardiac Pacemakers - Biological Aspects, Clinical Applications and Possible Complications

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“…25-29 Indeed, a study reported on the relationship between the presence of antibodies and development of DCM. 30 In another report, pacing at high heart rates was hypothesized to cause DCM. 31 Others have mentioned that the pacing site was related to developing detrimental ventricular remodeling.…”

Section: Discussionmentioning

confidence: 99%