Outcome of Cerebellar Injury in Very Low Birth-Weight Infants: 6 Case Reports

Bednarek, Nathalie; Akhavi, A.; Piètrement, Christine; Mesmin, F; Loron, Gauthier; Morville, P

doi:10.1177/0883073808318063

Cited by 27 publications

(26 citation statements)

References 16 publications

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“…Cerebellar injury was detected by neonatal head ultrasound (HUS) [22, 24-26] or on T1/T2-weighted images obtained from a preterm (<36 weeks GA) or a term-equivalent MRI study [9, 22, 26-29]. The severity of CBI varied from small punctate cerebellar hemorrhages (<4 mm) [9, 29, 30] to more severe forms of cerebellar injury including cerebellar infarction and resulting atrophy on conventional MRI [11, 23, 31, 32].…”

Section: Resultsmentioning

confidence: 99%

Developmental Cerebellar Cognitive Affective Syndrome in Ex-preterm Survivors Following Cerebellar Injury

2014

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Cerebellar injury is increasingly recognized as an important complication of very preterm birth. However, the neurodevelopmental consequences of early life cerebellar injury in prematurely born infants have not been well elucidated. We performed a literature search of studies published between 1997 and 2014 describing neurodevelopmental outcomes of preterm infants following direct cerebellar injury or indirect cerebellar injury/underdevelopment. Available data suggests that both direct and indirect mechanisms of cerebellar injury appear to stunt cerebellar growth and adversely affect neurodevelopment. This review also provides important insights into the highly integrated cerebral-cerebellar structural and functional correlates. Finally, this review highlights that early life impairment of cerebellar growth extends far beyond motor impairments and plays a critical, previously underrecognized role in the long-term cognitive, behavioral, and social deficits associated with brain injury among premature infants. These data point to a developmental form of the cerebellar cognitive affective syndrome previously described in adults. Longitudinal prospective studies using serial advanced magnetic resonance imaging techniques are needed to better delineate the full extent of the role of prematurity-related cerebellar injury and topography in the genesis of cognitive, social-behavioral dysfunction.

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Section: Resultsmentioning

confidence: 99%

Developmental Cerebellar Cognitive Affective Syndrome in Ex-preterm Survivors Following Cerebellar Injury

2014

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“…14,[35][36][37][38][39][40][41][42] Premature births can interrupt cerebellum growth. Investigation of whether the adverse effect or prematurity on cerebellar dimensions persists after birth has shown smaller cerebellar dimensions in children born prematurely compared to those born at term.…”

Section: Discussionmentioning

confidence: 99%

“…This neural tube subsequently differentiates in the rostral area to form the cerebrum and cerebellum. Development of the cerebellum begins in days [40][41][42][43][44][45], and the fissurae cerebelli and folia cerebelli appear in the cerebellum at the end of the 4th month. The cerebellum is part of the hindbrain, located below the temporal and occipital lobes.…”

Section: Assessment Of Cerebellar Dimensions Usingmentioning

confidence: 99%

Assessment of Cerebellar Dimensions Using Magnetic Resonance Imaging in Children Aged 0-4 Years

Ayhan¹,

Yeğinoğlu²,

Kul³

2015

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Several diseases progress with cerebellar atrophy and hypoplasia. Cerebellum dimension measurements facilitating the assessment of decreases in cerebellum size on radiological images between the ages of 0 and 4 years in particular, when the cerebellum is still growing, will be of considerable use in clinical practice and appropriate for measurement value standardization. This will allow easier interpretetation of findings, together with more accurate diagnosis or a decrease in delays caused by false diagnosis. This study, the purpose of which was to obtain a database suitable for clinical use by performing cerebellar development dimension measurements in normal individuals aged 0-4 years, investigated the effect on cerebellar dimensions of parameters such as height, weight, head circumference and birth week. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : One hundred fourty children aged 0-4 years, 56 girls and 84 boys, undergoing magnetic resonance imaging of the brain at the Karadeniz Technical University Farabi Hospital Radiology Department with no structural cerebral or cerebellar abnormalities were included in the study. R Re es su ul lt ts s: : In this study of cerebellar dimensions in healthy children, these were positively correlated with weight, head circumference and height in both genders. Preterm birth had a significant effect on cerebellar dimensions. C Co on nc cl lu us si io on n: : In conclusion, this scale developed by measuring the cerebellar dimensions of healthy children aged 0-4 years will be of considerable practical assistance in terms of assessing measurements performed in a clinical environment. K Ke ey y W Wo or rd ds s: : Magnetic resonance imaging; child Ö ÖZ ZE ET T A Am ma aç ç: : Serebellumun atrofisi ve hipoplazisi ile giden birçok hastalık mevcuttur. Özellikle serebellumun büyümeye devam ettiği 0-4 yaş arasında radyolojik görüntülerde serebellum boyutlarındaki azalmanın değerlendirilebilmesi için serebellum boyutlarının ölçümleri, klinikte pratik olarak yararlı olacak ve ölçüm değerlerinin standardizasyonu için uygun olacaktır. Böylece bulguların daha kolay tanımlanabileceği ve doğru tanı konulamaması ya da tanı konulmasındaki gecikmelerin azalacağı öngörülmektedir. Bu nedenle 0-4 yaş arası normal bireylerde serebellum gelişimi boyut ölçümleri ile yaparak klinik kullanıma uygun bir veri dökümü elde etmeyi amaçladığımız bu çalışmada boy, kilo, baş çevresi, doğum haftası gibi parametrelerin serebellum boyutları üzerine etkilerini de değerlendirdik. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Araştırmaya Karadeniz Teknik Üniversitesi Radyoloji Bölümünde beyin manyetik rezonans görüntülemesi yapılan ve serebral ve serebellum anomalisi olmayan 0-4 yaş arasındaki 56 kız, 84 erkek çocuk dahil edilmiştir. B Bu ul lg gu ul la ar r: : Sağlıklı ço-cuklarda serebellum boyutlarını saptadığımız bu çalışmada, serebellum boyutlarının her iki cinsiyette boy, kilo ve baş çevresi ile pozitif korelasyon olduğu ve erken do...

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“…Cerebellar injury has been increasingly recognized as a characteristic injury of preterm infants. Neuroimaging studies have shown that the cerebellar injuries in preterm infants are correlated with supratentorial lesions, particularly PVL and intraventricular hemorrhage [6][7][8][9][10][11][12][13]. Despite these reports, the impact of cerebellar injury on the development of preterm infant might be under recognized.…”

Section: Introductionmentioning

confidence: 99%