The neurological outcomes of cerebellar injury in premature infants

Kobayashi, Satoru; Wakusawa, Keisuke; Inui, Tomoyuki; Tanaka, Soichiro; Kobayashi, Yasuko; Ônuma, Akira; Haginoya, Kazuhiro

doi:10.1016/j.braindev.2015.01.009

Cited by 8 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If the studies on autologous UCBT for cerebral palsy show a benefit, expectant mothers at risk of premature birth should be informed about private banking as UCB are not collected from premature babies for public use, premature babies are at higher risk of cerebral palsy and UCB from premature babies have higher CD34+ cell counts. 61 Discussion of the potential for UCB in regenerative medicine should be presented as speculation until further evidence of benefit is determined. Access to family banking for families with a medical indication (for example, sibling with leukemia, sickle cell anemia, thalassemia, congenital marrow failure or immunodeficiency (inherited metabolic diseases)) should be available to all qualifying families regardless of finances.…”

Section: Ethical Considerationsmentioning

confidence: 99%

Umbilical cord blood donation: public or private?

Ballen

Verter²,

Kurtzberg

2015

Bone Marrow Transplant

View full text Add to dashboard Cite

Umbilical cord blood (UCB) is a graft source for patients with malignant or genetic diseases who can be cured by allogeneic hematopoietic cell transplantation (HCT), but who do not have an appropriately HLA-matched family or volunteer unrelated adult donor. Starting in the 1990s, unrelated UCB banks were established, accepting donations from term deliveries and storing UCB units for public use. An estimated 730 000 UCB units have been donated and stored to date and ∼ 35 000 UCB transplants have been performed worldwide. Over the past 20 years, private and family banks have grown rapidly, storing ∼ 4 million UCB units for a particular patient or family, usually charging an up-front and yearly storage fee; therefore, these banks are able to be financially sustainable without releasing UCB units. Private banks are not obligated to fulfill the same regulatory requirements of the public banks. The public banks have released ∼ 30 times more UCB units for therapy. Some countries have transitioned to an integrated banking model, a hybrid of public and family banking. Today, pregnant women, their families, obstetrical providers and pediatricians are faced with multiple choices about the disposition of their newborn's cord blood. In this commentary, we review the progress of UCB banking technology; we also analyze the current data on pediatric and adult unrelated UCB, including the recent expansion of interest in transplantation for hemoglobinopathies, and discuss emerging studies on the use of autologous UCB for neurologic diseases and regenerative medicine. We will review worldwide approaches to UCB banking, ethical considerations, criteria for public and family banking, integrated banking ideas and future strategies for UCB banking.

show abstract

Section: Ethical Considerationsmentioning

confidence: 99%

Umbilical cord blood donation: public or private?

Ballen

Verter²,

Kurtzberg

2015

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…60 Extreme prematurity is associated with a high risk of developing peri-and postnatal supra-and infratentorial brain damages, including white matter loss, thinning of the corpus callosum, volume reduction of the cerebellum and brainstem, and atrophic dentate nuclei. 61,[65][66][67][68] Over time, patients present with motor and cognitive impairments of variable degrees. 61,[65][66][67][68] The cerebellum has its greatest increase of volume and surface during the third trimester of pregnancy.…”

Section: Nonprogressive Camentioning

confidence: 99%

“…61,[65][66][67][68] Over time, patients present with motor and cognitive impairments of variable degrees. 61,[65][66][67][68] The cerebellum has its greatest increase of volume and surface during the third trimester of pregnancy. 66,67 As this process is highly energy demanding, the developing cerebellum is prone to injury.…”

Section: Nonprogressive Camentioning

confidence: 99%

Neuroimaging in cerebellar ataxia in childhood: A review

Serrallach

Orman

Boltshauser

et al. 2022

Journal of Neuroimaging

View full text Add to dashboard Cite

Ataxia is one of the most common pediatric movement disorders and can be caused by a large number of congenital and acquired diseases affecting the cerebellum or the vestibular or sensory system. It is mainly characterized by gait abnormalities, dysmetria, intention tremor, dysdiadochokinesia, dysarthria, and nystagmus. In young children, ataxia may manifest as the inability or refusal to walk. The diagnostic approach begins with a careful clinical history including the temporal evolution of ataxia and the inquiry of additional symptoms, is followed by a meticulous physical examination, and, depending on the results, is complemented by laboratory assays, electroencephalography, nerve conduction velocity, lumbar puncture, toxicology screening, genetic testing, and neuroimaging.Neuroimaging plays a pivotal role in either providing the final diagnosis, narrowing the differential diagnosis, or planning targeted further workup. In this review, we will focus on the most common form of ataxia in childhood, cerebellar ataxia (CA). We will discuss and summarize the neuroimaging findings of either the most common or the most important causes of CA in childhood or present causes of pediatric CA with pathognomonic findings on MRI. The various pediatric CAs will be categorized and presented according to (a) the cause of ataxia (acquired/disruptive vs. inherited/genetic) and (b) the temporal evolution of symptoms (acute/subacute, chronic, progressive, nonprogressive, and recurrent).

show abstract