Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections

Abstract

The aim of this study was to evaluate the impact of carbapenem-resistant K. pneumoniae bloodstream infections on mortality. During the study period 42, 68 and 120 patients were identified with carbapenem-resistant, extended-spectrum β-lactamase producers (ESBL) and susceptible K. pneumoniae bloodstream infections, respectively. Patients with carbapenem-resistant K. pneumoniae had higher rates of prior antimicrobial exposure, other nosocomial infections, and use of invasive devices. Infection-related mortality was 48% for carbapenem-resistant, 22% for ESBL producers and 17% for susceptible K. pneumoniae. Independent risk factors for infection-related mortality were Pitt bacteraemia score, Charlson score and carbapenem resistance.

Emergence of carbapenem-resistant Klebsiella spp. infections in a Turkish university hospital: epidemiology and risk factors

“…Several reports have shown that carbapenem resistance was independently associated with an increase in mortality [21][22][23]. In our study, attack mortality rate was significantly higher in patients infected with carbapenem-resistant strains.…”

Antimicrobial Susceptibility and Microorganisms Isolated from Blood Cultures of Hospitalized Patients in Intensive Care Units

“…Kan dolaşımı sistemi enfeksiyonlarının tedavisinde çoğul dirençli mikroorganizmalardan özellikle GSBL üretenler sorunlar oluşturmaktadır (4,(21)(22)(23). Karbapenemler GSBL üreten ve çoğul dirençli mikroorganizmaların tedavisinde en etkili antibiyotikler olmasına rağmen sık kullanımları durumunda bunlara karşı da direnç gelişimi oluşmaktadır (22,24,25). Çalışmamızda Acinetobacter spp.…”

Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen

“…Komorbiditäten wurden in etlichen Studien als signifikante Risikofaktoren gefunden [183,186,[188][189][190]. Daneben fanden sich eine kürzliche Organtransplantation [198], vorhergehende Operationen [185,190] oder nicht operative Eingriffe [189], zentrale Gefäßzugän-ge [183,187,189,198], mechanische Beatmung [185,190,198], Magensonden [187,190], Harnwegskatheter [187,189], Wunden [187], Aufenthalt auf Intensivstationen [183,185,187,189,198], vorhergehende Hospitalisierung [189] und die Dauer des Krankenhausaufenthaltes [183,187,190,198] [140]. Auf 16 deutschen Intensivstationen entwickelten 10 % der Patienten, die mit 3.…”

“…In einer anderen Studie fand sich bei 26 % aller Patienten mit positiver S urveillance-Kultur im weiteren Verlauf eine positive mikrobiologische Probe und zwar im Median neun Tage nach der Surveillance-Kultur [183].…”