Outcome differences in younger and older patients with laryngeal cancer: A retrospective case-control study

Singh, Bhuvanesh; Alfonso, Antonio E.; Sabin, Steven; Poluri, Ashok; Shaha, Ashok R.; Sundaram, Krisnamurti; Lucente, Frank E.

doi:10.1016/s0196-0709(00)85004-8

Cited by 40 publications

(50 citation statements)

References 22 publications

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“…This is consistent with other reports (Singh et al, 2000;Warnakulasuriya et al, 2007). However, a few authors have not found the independent effect of age on survival (De Paula et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Pruegsanusak¹,

Peeravut²,

Leelamanit³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 92%

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Pruegsanusak¹,

Peeravut²,

Leelamanit³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…A number of previous studies compared younger and older patients with laryngeal SCC and did not observe any differences in tumor location or disease stage (4,13). The tumor locations reported in the current study were similar to those previously reported in the literature, with the glottis being the most prevalent location followed by the supraglottis (14).…”

Section: Discussionsupporting

confidence: 88%

“…Classical risk factors, including smoking and alcohol, are not as prevalent among young patients as in older ones (4,5). This has led to the assumption that the carcinogenic effect of tobacco is not the primary cause of cancer in young patients and that this disease has a different etiology.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics and outcome of laryngeal squamous cell carcinoma in young adults

et al. 2016

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Abstract. Laryngeal carcinoma rarely occurs in the young adult population. Therefore, the optimal treatment for this age group is unclear, specifically regarding organ preservation treatment. In order to assess the distinct characteristics of laryngeal squamous cell carcinoma (SCC) in young adults and describe the effect of treatment on survival, a retrospective chart review of all patients aged <40 years, who were treated in a tertiary referral center for laryngeal SCC between January 1960 and December 2013, was performed. Patients who were treated prior to and following the Veterans study, representing an arbitrary point which started the organ preservation era, were compared. A total of 29 patients (male:female ratio, 2.6:1) were identified. The mean age at diagnosis was 35±5 years and 17 patients (59%) were smokers. In total, 12 (41%) of patients were stage I, 4 (14%) were stage II, 8 (28%) were stage III and 5 (17%) were stage IV. Glottic tumors were present in 20 (69%) of patients and supraglottic tumors in 6 (21%); the site of tumor origin could not be determined in 3 (10%) of patients. Surgery was performed in 11 (38%) of patients, radiation in 21 (72%) and chemotherapy in 5 (17%). A comparison between patients treated prior to and following the Veterans study demonstrated a 2-year higher laryngectomy-free survival rate of 53% and 78%, respectively (P=0.299). The 2-year disease-free survival rate was 93% for patients who were treated prior to the Veterans study and 71% for patients who were treated after (P=0.001), with no significant change in overall survival (P= 0.413). The results suggest that the characteristics and behavior of laryngeal carcinoma in young adults is similar to older adults. Higher rates of 2-year laryngectomy-free survival were noted in patients treated following the organ preservation era with no significant difference in survival compared with patients who were treated before.

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“…While conventional therapy is feasible in the aged population, several case-control studies have demonstrated that advanced age may adversely affect local control and disease-specific survival. 32,33 In each of these studies, the authors failed to speculate on the relationship between age and survival. However, Clayman et al 32 reviewed 43 patients aged 80 years and older in a case-control study and found that only 23.3 per cent of the octogenarians were treated with adjuvant therapy while 44.1 per cent of the younger controls received adjuvant therapy.…”

Section: Impact Of Age On Tumour Biologymentioning

confidence: 99%

Treatment considerations for head and neck cancer in the elderly

et al. 2005

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As life expectancy increases, surgeons can expect an increasing number of geriatric patients. In turn, the number of elderly patients presenting with head and neck cancer is likely to increase. Management of this subpopulation has become a source of debate because there is a paucity of randomized data regarding the effect of age on treatment response and morbidity associated with the treatment of head and neck cancer. The management of head and neck cancer in the elderly depends on the patient's age and general condition, the stage of disease, the effects of treatment on quality of life (such as speech and swallowing), patient and family wishes, and active physician participation in continued care. Elderly patient's comorbid conditions need appropriate attention especially if surgery is to be undertaken. The aim of this review is to examine the current literature in an attempt to develop an approach to the treatment of the elderly patient with head and neck cancer and to define the pertinent issues that require further study.

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Outcome differences in younger and older patients with laryngeal cancer: A retrospective case-control study

Cited by 40 publications

References 22 publications

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Characteristics and outcome of laryngeal squamous cell carcinoma in young adults

Treatment considerations for head and neck cancer in the elderly

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