Outcome and Prognostic Factors for Canine Splenic Lymphoma Treated by Splenectomy (1995–2011)

Abstract

Based on our sample population, splenectomy alone was an effective treatment for splenic lymphoma in cases with disease confined to the spleen. Chemotherapy may not improve survival in cases of lymphoma restricted to the spleen.

Histopathological and immunophenotypical assessment of canine primary splenic lymphoma according to the World Health Organization

“…These data corroborate the few studies from other countries, where the incidence of indolent lymphomas in the spleen was higher compared to high grade lymphomas (Van Stee et al 2015). A study of 28 cases of primary splenic lymphoma showed 71.4% of indolent tumors and marginal zone B-cell lymphoma was also the most prevalent (39.3% of cases), followed by mantle cell lymphoma (32.1%) (Van Stee et al 2015). Interestingly, although mantle cell lymphoma was the second most common in that study, no case of this type was seen in the present study.…”

“…Indolent splenic lymphomas were more prevalent (63.7%) in this study, of which 60.7% of the cases were diagnosed as marginal zone B-cell lymphoma. These data corroborate the few studies from other countries, where the incidence of indolent lymphomas in the spleen was higher compared to high grade lymphomas (Van Stee et al 2015). A study of 28 cases of primary splenic lymphoma showed 71.4% of indolent tumors and marginal zone B-cell lymphoma was also the most prevalent (39.3% of cases), followed by mantle cell lymphoma (32.1%) (Van Stee et al 2015).…”

“…The distinction between indolent and high-grade lymphomas, such as lymphoblastic T-cell lymphoma (12.1% of the cases) is important, since the prognosis is quite different and they require individualized treatment (Van Stee et al 2015). One study showed that 1-year survival time for marginal zone lymphoma represents 63.6% of the cases, whereas high-grade T-cell lymphomas are associated with shorter survival (Van Stee et al 2015).…”

“…The most widely used histological classification system for canine lymphoma is the World Health Organization (WHO) classification (Vezzali et al 2009, Valli et al 2011. Recent uses of this system with primary splenic lymphoma have demonstrated that the most common histological type is marginal zone B-cell lymphoma, which shows indolent progression and better prognosis compared to the most common multicentric type, the diffuse large B-cell lymphoma (O'Brien et al 2013, Van Stee et al 2015. Marginal zone lymphoma in the spleen has low mitotic rate and slow progression, which represents a challenge for pathologists to reach a diagnosis, due to its similarity with benign marginal zone hyperplasia.…”

The Comparative Diagnostic Features of Canine and Human Lymphoma

“…The vast majority of cases lack detectable peripheral node infiltration and peripheral blood or bone marrow involvement appears to be very uncommon. Biologically, cMCL is reported to be an indolent disease and a series of nine dogs with splenic MC had a 1 year survival rate of 88.9% and an overall survival period of 502 days [113]. …”