Outcome after wait-listing for emergency liver transplantation in acute liver failure: A single centre experience

Bernal, William; Cross, Timothy J.S.; Auzinger, G.; Sizer, Elizabeth; Heneghan, Michael A.; Bowles, Matthew; Muiesan, Paolo; Rela, Mohammed; Heaton, Nigel; Wendon, Julia; O’Grady, John

doi:10.1016/j.jhep.2008.09.012

Cited by 151 publications

(140 citation statements)

References 25 publications

(33 reference statements)

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“…However, in some cases HBV infection is associated with liver failure, a critical condition which is associated with high mortality and requires LTx in severe cases [20]. …”

Section: Discussionmentioning

confidence: 99%

Hepatitis B-Associated Acute Liver Failure: Immediate Treatment with Entecavir Inhibits Hepatitis B Virus Replication and Potentially Its Sequelae

Jochum¹,

Gieseler²,

Gawlista³

et al. 2009

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Background: Acute hepatitis B virus (HBV) infection is followed by high viral replication rates leading to hepatocyte death and ultimately, in some cases, to acute liver failure (ALF) necessitating liver transplantation. Thus, the objective of treating HBV-induced ALF is to eliminate or significantly suppress HBV replication. Methods/Results: This prospective study (02/2008–02/2009) included 6 patients (1 female and 5 males, median age 35.5 years). HBV DNA and hepatitis B surface antigen (HBsAg) levels were detected, and hepatocyte death was quantified in patients’ sera by (a) M65 ELISA and (b) M30 ELISA. All patients received entecavir treatment at 1 mg daily within 1–18 days after admission. Upon treatment, pathologic parameters rapidly decreased and returned to normal values or trace amounts (HBV DNA) within 3 months in all of the cases. A seroconversion to anti-HBsAg was achieved in 5 out of 6 patients; one patient with late onset of treatment did not seroconvert. M65 and the difference of M65-M30 as a marker for cell necrosis dropped significantly within 1 week of treatment. Conclusion: This preliminary series of 6 patients reveals that immediate treatment of HBV-induced ALF with entecavir is well tolerated and beneficially affects the course of the disease.

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“…However, in some cases HBV infection is associated with liver failure, a critical condition which is associated with high mortality and requires LTx in severe cases [20]. …”

Section: Discussionmentioning

confidence: 99%

Hepatitis B-Associated Acute Liver Failure: Immediate Treatment with Entecavir Inhibits Hepatitis B Virus Replication and Potentially Its Sequelae

Jochum¹,

Gieseler²,

Gawlista³

et al. 2009

Digestion

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“…18 Of patients who present with ALF, 71% meet the criteria for transplant, 22% to 43% are listed, but only 29% to 56% are transplanted. 4,5,95 Liver transplant waiting list mortality is 6.3% to 27.7%. 1,5,6,18,95 The majority who were listed but not transplanted died waiting for a liver while the remainder was considered too sick for transplant when an organ was available.…”

Section: Prognosismentioning

confidence: 99%

Acute Liver Failure

Punzalan

Barry

2016

J Intensive Care Med

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Acute liver failure is life threatening liver injury with coagulopathy and hepatic encephalopathy within 26 weeks and generally, in the absence of preexisting liver disease. Fulminant liver failure occurs when hepatic encephalopathy occurs within 8 weeks of jaundice. The majority of patients with ALF are women with the median age of 38 years. In the United States, drug induced liver injury including acetaminophen causes the majority of ALF cases. The etiology of ALF should be determined, if possible, because many causes have a specific treatment. The mainstay for ALF is supportive care and liver transplantation, if necessary. There are multiple prognostic criteria available. Prognosis can be poor and patients should be referred to a liver transplantation center as soon as possible.

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“…Survival outcomes for patients with acute liver failure (ALF) have been transformed by the introduction of emergency liver transplantation (ELT) [1][2][3][4]. However, the ideal means for the identification and selection of those patients likely to benefit from this procedure remains a subject of some controversy [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of performance of Kings’s College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure

McPhail¹,

Wendon²,

Bernal³

2010

Journal of Hepatology

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Outcome after wait-listing for emergency liver transplantation in acute liver failure: A single centre experience

Cited by 151 publications

References 25 publications

Hepatitis B-Associated Acute Liver Failure: Immediate Treatment with Entecavir Inhibits Hepatitis B Virus Replication and Potentially Its Sequelae

Hepatitis B-Associated Acute Liver Failure: Immediate Treatment with Entecavir Inhibits Hepatitis B Virus Replication and Potentially Its Sequelae

Acute Liver Failure

Meta-analysis of performance of Kings’s College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure

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