Outbreak of tuberculosis caused by Mycobacterium bovis in golden Guernsey goats in Great Britain

Abstract

An outbreak of caprine tuberculosis caused by Mycobacterium bovis was disclosed in June 2008, affecting goats of the golden Guernsey breed kept on 10 separate smallholdings in south-west Wales and the west of England. Following the initial diagnosis at postmortem examination, 30 goats that reacted positively to the single intradermal comparative cervical tuberculin (SICCT) test, together with five in-contact animals, were euthanased and subjected to postmortem examination and mycobacterial culture. Spoligotyping and variable number tandem repeat analysis of isolates showed that they were all of the same genotype, endemic to south-west Wales. Retrospective movement tracings identified a goat herd in south-west Wales, by then completely dispersed, as the probable common source of infection. There was a perfect correlation between the SICCT test and culture results in all slaughtered goats. Grossly visible tubercular lesions were observed at postmortem examination in all but one reactor.

Experimental Model of Tuberculosis in the Domestic Goat after Endobronchial Infection with Mycobacterium caprae

“…A high challenge dose (higher than 10 6 CFU) by nonnatural routes (such as intravenous or subcutaneous) may lead to systemic dissemination of infection, with lesions that are not representative of natural field cases (40). Using a relative low challenge dose of 1.5 ϫ 10 3 CFU by the endobronchial route, we have been able to reproduce typical granulomatous caseous necrotizing lesions in the lung and lung-associated LN in 11 out of 11 experimentally infected goats, resembling those observed in naturally infected goats (12,31), and as seen sometimes in natural cases, the majority of our Infected 572…”

“…In natural infections, TB in goats, as in cattle, is primarily a lower respiratory tract disease, with lesions in the lungs and associated lymph nodes (LN). Occasionally, tuberculous lesions may also be found in the upper respiratory tract lymph nodes and other organs, like the spleen, liver, or mesenteric lymph nodes (12,31). Histologically, the lesions are similar to those observed in cattle and humans.…”

“…In natural cases of TB, a The total volumes of lesions and the percentages of lungs affected were calculated using 64-slice MDCT and were compared to direct visual quantification by slicing, photography, and image analysis. Means (95% CI) were as follows: volume of lesions in lung (cm on May 10, 2018 by guest http://cvi.asm.org/ such large lesions with liquefactive necrosis and caverna formation are usually associated with a long period of lesion progression in herds not subjected to eradication (12,14,31). In contrast, in trials carried out in other species, like badgers (10) and calves (39), using the endobronchial route of infection, lesions progressed slowly, resembling what is observed in natural cases of TB in these species.…”

Prevalence of tuberculosis-like lesions in goats slaughtered at Bauchi central abattoir, Bauchi State

“…Most commonly in goats, the cough is usually seen as a chronic cough which is unresponsive to treatment and may be accompanied by gradual loss of weight and sometimes diarrhoea (Aranaz et al, 2003). The Predilection site for tuberculosis in goats is the lower respiratory tract and the associated lymph nodes (Daniel et al, 2009). Epidemiological studies have indicated that tuberculosis in goat and sheep has a wide global distribution, being reported in several countries of the world including New Zealand, Sudan, Spain, Nigeria, the United Kingdom, Italy, Algeria and Ethiopia (Aranaz et al, 1999).…”

Assessment of Goat Tuberculosis Model for Use in Vaccine Trials

“…Caprine TB is an emerging zoonotic disease in many European countries [1,2]. Vaccination could be taken into consideration as an alternative to test-and-slaughter strategy for long-term TB control in livestock [3].…”