Outbreak of Serratia marcescens infection due to contamination of multiple-dose vial of heparin–saline solution used to flush deep venous catheters or peripheral trocars

Liu, D.; Zhang, L.-P.; Huang, Shiang‐Fu; Wang, Z.; Chen, P.; Wang, H.; Cheng, Yu-Chieh

doi:10.1016/j.jhin.2010.10.003

Cited by 14 publications

(9 citation statements)

References 7 publications

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“…This may have been due to contaminated heparin still present in intravenous catheters that was later flushed; however, prefilled saline syringes produced by the same company were also contaminated with S. marcescens, and when these were also recalled the outbreak ended (67). Another outbreak of S. marcescens bloodstream infections was described for September 2009 in China, where multidose heparin vials were contaminated; this was not due to the same manufactured product that was responsible for the multistate outbreak in the United States (241). In this outbreak, nine patients were affected (241).…”

Section: S Marcescensmentioning

confidence: 99%

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Serratia Infections: from Military Experiments to Current Practice

2011

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SUMMARY Serratia species, in particular Serratia marcescens , are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens , were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens , and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens , this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens , and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.

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Section: S Marcescensmentioning

confidence: 99%

“…Another outbreak of S. marcescens bloodstream infections was described for September 2009 in China, where multidose heparin vials were contaminated; this was not due to the same manufactured product that was responsible for the multistate outbreak in the United States (241). In this outbreak, nine patients were affected (241).…”

Section: S Marcescensmentioning

confidence: 99%

Serratia Infections: from Military Experiments to Current Practice

2011

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“…Yurtdışında yayınlanan farklı çalışmalarda (9,20,24,26,32) Serratia'nın etken olduğu hastane enfeksiyonlarında çok değişik kaynakların rezervuar olabileceği kaydedilmiştir. Örneğin inhalasyon cihazlarında kullanılan kontamine solüsyonlar, parenteral beslenme sıvıları, herhangi bir nedenle kullanılan serum fizyolojik ve kullanılan antiseptiklerin kontaminasyon sonucu bu bakterileri barındırabildikleri ispatlanmıştır.…”

Section: Bulgularunclassified

“…Bu bakteri grubunun intravenöz, intraperitoneal ve üriner kateterler ile birlikte bazı antiseptik solüsyonlarında kolonizasyonu sonucu gelişen hastane enfeksiyonları tipiktir. Yaplan çalışmalarda hastane personeli tarafından elden ele yatay bulaş sonucu salgınlar görülebileceği bildirilmiştir (3,9,20,24,26,32) .…”

Section: Introductionunclassified

Identification of Serratia species, clinical distribution, antibiotic susceptibility

Atmaca¹,

Özekinci²,

Yakut³

et al. 2018

Ankem Derg

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“…However, multidose vial-associated infections certainly occur in human medicine, and there is no reason to think that they would not also occur in veterinary medicine. Examples from humans include outbreaks of invasive Staphylococcus aureus infection from contaminated analgesic vials, 15 Serratia marcescens outbreak from heparin-saline catheter flush solution, 16 sepsis from propofol, 17 S marcescens endophthalmitis outbreak from bevacizumab, 18 Enterobacter cloacae bloodstream infections from human albumin, 19 hepatitis C infection from anesthetic agents, 20 and S aureus joint and soft tissue infections from lidocaine. 21 A large outbreak of fungal meningitis occurred from contamination corticosteroids that were being used for epidural injection.…”

Section: Contamination Of Multidose Itemsmentioning

confidence: 99%

Cleaning and Disinfection of Patient Care Items, in Relation to Small Animals

Weese

2015

Veterinary Clinics of North America: Small Animal Practice

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Outbreak of Serratia marcescens infection due to contamination of multiple-dose vial of heparin–saline solution used to flush deep venous catheters or peripheral trocars

Cited by 14 publications

References 7 publications

Serratia Infections: from Military Experiments to Current Practice

Serratia Infections: from Military Experiments to Current Practice

Identification of Serratia species, clinical distribution, antibiotic susceptibility

Cleaning and Disinfection of Patient Care Items, in Relation to Small Animals

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