Outbreak of Nontuberculous Mycobacterial Disease in the Central Pacific

Lillis, Joseph V.; Ansdell, David

doi:10.1016/j.det.2010.09.008

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…A recent study described the identification of the M . fortuitum complex in Polynesian residents with suspected tuberculosis [31] and other reports from the area highlight NTM-associated skin disease [32, 33]. On Australia, M .…”

Section: Discussionmentioning

confidence: 99%

Environmental Nontuberculous Mycobacteria in the Hawaiian Islands

et al. 2016

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Lung disease caused by nontuberculous mycobacteria (NTM) is an emerging infectious disease of global significance. Epidemiologic studies have shown the Hawaiian Islands have the highest prevalence of NTM lung infections in the United States. However, potential environmental reservoirs and species diversity have not been characterized. In this cross-sectional study, we describe molecular and phylogenetic comparisons of NTM isolated from 172 household plumbing biofilms and soil samples from 62 non-patient households and 15 respiratory specimens. Although non-uniform geographic sampling and availability of patient information were limitations, Mycobacterium chimaera was found to be the dominant species in both environmental and respiratory specimens. In contrast to previous studies from the continental U.S., no Mycobacterium avium was identified. Mycobacterium intracellulare was found only in respiratory specimens and a soil sample. We conclude that Hawai’i’s household water sources contain a unique composition of Mycobacterium avium complex (MAC), increasing our appreciation of NTM organisms of pulmonary importance in tropical environments.

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Section: Discussionmentioning

confidence: 99%

Environmental Nontuberculous Mycobacteria in the Hawaiian Islands

et al. 2016

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“…In agreement with this result, M. marinum was also found as the commonest species in Israeli patients, indicating that M. marinum is the commonest species in the Middle East region. Moreover, M. marinum was also found as the commonest AM among different geographic regions including high‐population communities such as Chinese, or small populations such as Satowan island in the central Pacific …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, M. marinum was also found as the commonest AM among different geographic regions including high-population communities such as Chinese, 17 or small populations such as Satowan island in the central Pacific. 18 Clinical diagnosis of AMCI is difficult because there are no characteristic clinical features of the lesions. The commonest clinical presentation included erythematous plaques and nodules with tendency for hyperkeratosis, crusting and superficial ulcerations, sometimes as sporotrichoid lymphocutaneous infection.…”

Section: Discussionmentioning

confidence: 99%

Atypical mycobacterial cutaneous infections in Egyptians: A clinicopathological study

El‐Khalawany

2014

The Journal of Dermatology

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Atypical mycobacteria comprise an uncommon heterogenous non-tuberculous group of acid-fast bacteria that rarely involve skin. The pattern of atypical mycobacterial cutaneous infections (AMCI) has not been previously studied in Egypt. The aim of this study was to describe the clinical characteristics, pathological features and species profile of AMCI among Egyptian patients. A retrospective study included 46 cases, diagnosed with AMCI during the period 2002 to 2012. The study included 34 males (73.9%) and 12 females (26.9%). The average age of patients was 39 years while the average duration of lesions was 15 months. The lesions were mostly located on the extremities (91.3%) and there was predominance of single (65.2%) and nodular (41.4%) lesions. History of trauma was confirmed in 91.3%. Histologically, the granulomas were mostly superficial (67.4%) with predominance of nodular suppurative pattern (84.8%). Other significant histological findings included epidermal hypertrophy (100%), presence of large-sized multinucleated giant cells (87%) and intrafollicular neutrophilic abscesses (84.8%). The diagnosis was proved by direct smear in 6.5%, skin biopsy in 10.9%, tissue culture in 47.8% and polymerase chain reaction (PCR) in 34.8%. Isolated species included Mycobacterium marinum (84.8%), Mycobacterium fortuitum (10.9%) and Mycobacterium kansasii (4.3%). Although the results of this study recommend that the diagnosis of AMCI is based mainly on culture and PCR, other clinicopathological features such as history of trauma, acral location of the lesion and suppurative granulomatous reaction with intrafollicular abscesses could be helpful clues in suspecting AMCI.

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“…Non-tuberculous mycobacteria (NTM) are isolated from human and environmental samples all over the world1, including tropical areas and remote countries and territories2. Our recent investigation of mycobacteria in French Polynesia, a remote French territory composed of 117 islands in the South Pacific3, indicated that rapidly-growing mycobacteria formed the most prevalent group of NTM in human respiratory tract specimens3.…”

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confidence: 99%

“Mycobacterium massilipolynesiensis” sp. nov., a rapidly-growing mycobacterium of medical interest related to Mycobacterium phlei

Phelippeau

Asmar

Osman

et al. 2017

Sci Rep

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In French Polynesia, respiratory tract clinical isolate M26, displayed unusual phenotype and contradictory phylogenetic affiliations, suggesting a hitherto unidentified rapidly-growing Mycobacterium species. The phenotype of strain M26 was further characterized and its genome sequenced. Strain M26 genome consists in a 5,732,017-bp circular chromosome with a G + C% of 67.54%, comprising 5,500 protein-coding genes and 52 RNA genes (including two copies of the 16 S rRNA gene). One region coding for a putative prophage was also predicted. An intriguing characteristic of strain M26’s genome is the large number of genes encoding polyketide synthases and nonribosomal peptide synthases. Phylogenomic analysis showed that strain M26’s genome is closest to the Mycobacterium phlei genome with a 76.6% average nucleotide identity. Comparative genomics of 33 Mycobacterium genomes yielded 361 genes unique to M26 strain which functional annotation revealed 84.21% of unknown function and 3.88% encoding lipid transport and metabolism; while 48.87% of genes absent in M26 strain have unknown function, 9.5% are implicated in transcription and 19% are implicated in transport and metabolism. Strain M26’s unique phenotypic and genomic characteristics indicate it is representative of a new species named “Mycobacterium massilipolynesiensis”. Looking for mycobacteria in remote areas allows for the discovery of new Mycobacterium species.

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Outbreak of Nontuberculous Mycobacterial Disease in the Central Pacific

Cited by 7 publications

References 6 publications

Environmental Nontuberculous Mycobacteria in the Hawaiian Islands

Environmental Nontuberculous Mycobacteria in the Hawaiian Islands

Atypical mycobacterial cutaneous infections in Egyptians: A clinicopathological study

“Mycobacterium massilipolynesiensis” sp. nov., a rapidly-growing mycobacterium of medical interest related to Mycobacterium phlei

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