Out-of-hospital cardiac arrest after acute cocaine intoxication associated with Brugada ECG patterns: Insights into physiopathologic mechanisms and implications for therapy

Mazloum, R El; Snenghi, Rossella; Zorzi, Alessandro; Zilio, Filippo; Dorigo, A; Montisci, Roberta; Corrado, Domenico; Montisci, Massimo

doi:10.1016/j.ijcard.2015.04.249

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…It is quite likely that these patients express a sodium channel mutation described in association with Brugada abnormality and that the sodium channel blocking properties of cocaine made the patients' underlying physiological abnormality more evident [4]. Recently, El Mazloum et al reported four cases of out-of-hospital cardiac arrest after acute cocaine intoxication associated with Brugada ECG patterns [17]. Cocaine abuse should be stopped.…”

Section: Sodium Channel Blockadementioning

confidence: 99%

Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

Ouali¹,

Guermazi²,

Guermazi³

et al. 2018

Cardiac Arrhythmias

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Toxicomania is a worldwide emerging problem threatening young population. Several reports highlighted its hazardous cardiovascular effects. Sudden cardiac death secondary to cardiac arrhythmias is the most occupying issue. Different forms of cardiac rhythm disorders may be induced by illicit drug abuse according to the type of drug and the mechanism involved. In this review, we exposed the main ventricular and supraventricular arrhythmia complicating the common recreational drugs, and we explained their different mechanisms as well as the particularities of management.

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Section: Sodium Channel Blockadementioning

confidence: 99%

Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

Ouali¹,

Guermazi²,

Guermazi³

et al. 2018

Cardiac Arrhythmias

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“…This may influence the QT interval [ 24 ]. The presence of some cardiovascular pathologies, for example, coronary disease, could be the lethal trigger if quetiapine is used, as seen in polydrug intoxications [ 25 , 26 ]. Quetiapine’s deadly effect is governed by whether some medication potentiates this inhibition effect and, if so, to what extent [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Quetiapine-Related Deaths: In Search of a Surrogate Endpoint

Šoša

2024

Toxics

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Quetiapine is a second-generation antipsychotic drug available for two and half decades. Due to increased misuse, prescription outside the approved indications, and availability on the black market, it is being encountered in medicolegal autopsies more frequently. For instance, it has been linked to increased mortality rates, most likely due to its adverse effects on the cardiovascular system. Its pharmacokinetic features and significant postmortem redistribution challenge traditional sampling in forensic toxicology. Therefore, a systematic literature review was performed, inclusive of PubMed, the Web of Science—core collection, and the Scopus databases; articles were screened for the terms “quetiapine”, “death”, and “autopsy” to reevaluate each matrix used as a surrogate endpoint in the forensic toxicology of quetiapine-related deaths. Ultimately, this review considers the results of five studies that were well presented (more than two matrices, data available for all analyses, for instance). The highest quetiapine concentrations were usually measured in the liver tissue. As interpreted by their authors, the results of the considered studies showed a strong correlation between some matrices, but, unfortunately, the studies presented models with poor goodness of fit. The distribution of quetiapine in distinct body compartments/tissues showed no statistically significant relationship with the length of the postmortem interval. Furthermore, this study did not confirm the anecdotal correlation of peripheral blood concentrations with skeletal muscle concentrations. Otherwise, there was no consistency regarding selecting an endpoint for analysis.

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