Our recommendations for avoiding exposure to fungi outside the hospital for patients with haematological cancers

Ariza-Heredia, Ella J.; Kontoyiannis, Dimitrios P.

doi:10.1111/myc.12167

Cited by 16 publications

(13 citation statements)

References 51 publications

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“…The fungus is the most serious human filamentous fungal pathogen [51], which is a more important threat than mycotoxin production. It is possible that farm workers, or those in contact with food, could be increasingly exposed to this fungus as climate change progresses: more exposure of immunocompromised or other at risk people could occur [52,53]. …”

Section: Thermotolerant and Thermophilic Fungimentioning

confidence: 99%

Thermophilic Fungi to Dominate Aflatoxigenic/Mycotoxigenic Fungi on Food under Global Warming

Paterson

Lima

2017

IJERPH

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Certain filamentous fungi produce mycotoxins that contaminate food. Mycotoxin contamination of crops is highly influenced by environmental conditions and is already affected by global warming, where there is a succession of mycotoxigenic fungi towards those that have higher optimal growth temperatures. Aflatoxigenic fungi are at the highest limit of temperature although predicted increases in temperature are beyond that constraint. The present paper discusses what will succeed these fungi and represents the first such consideration. Aflatoxins are the most important mycotoxins and are common in tropical produce, much of which is exported to temperate regions. Hot countries may produce safer food under climate change because aflatoxigenic fungi will be inhibited. The same situation will occur in previously temperate regions where these fungi have recently appeared, although decades later. Existing thermotolerant and thermophilic fungi (TTF) will dominate, in contrast to the conventional mycotoxigenic fungi adapting or mutating, as it will be quicker. TTF produce a range of secondary metabolites, or potential mycotoxins and patulin which may become a new threat. In addition, Aspergillus fumigatus will appear more frequently, a serious human pathogen, because it is (a) thermotolerant and (b) present on crops: hence this is an even greater problem. An incubation temperature of 41 °C needs employing forthwith to detect TTF. Finally, TTF in crops requires study because of the potential for diseases in humans and animals under climate change.

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Section: Thermotolerant and Thermophilic Fungimentioning

confidence: 99%

Thermophilic Fungi to Dominate Aflatoxigenic/Mycotoxigenic Fungi on Food under Global Warming

Paterson

Lima

2017

IJERPH

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“…Immunosuppressed people are susceptible, such as individuals with AIDS [3] and those undergoing transplantation and chemotherapy, although immunocompetent individuals can succumb [4]. The presence of these fungi in/on foods represents a threat to patients as fomites [4,5,6,7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

“…Invasive pulmonary disease usually only occurs in immunocompromised patients with inhalation being the primary source of infection. Gastrointestinal routes are sources of infection for fungi and many precautions are already made enabling patients to avoid eating suspect foods [4,5,6,7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

“…Some Mucor species contain strains which are significant infective agents of immunocompromised patients [13,14], although it is probable that high numbers of cases are unrecorded from difficulties with identification of taxa [9,10], which would be assisted by knowledge of those recorded previously. Interestingly, potentially human infective strains of Mucor circinelloides have been isolated recently from yogurts, which were the presumed causal organism for illness in >200 consumers [15].…”

Section: Introductionmentioning

confidence: 99%

“…Medical researchers may isolate fungi from food de novo (e.g., [5,6,7,8,9]), perhaps unnecessarily in some cases, as the information already exists, albeit in a dispersed manner. Furthermore, food mycologists underestimate the significance of FFHP from food in their quest for high quality food, although species of Aspergillus , Penicillium and Fusarium are studied extensively often from the point of view of: (a) mycotoxin production [4,40]; (b) deterioration of organoleptic properties; or (c) plant pathology.…”

Section: Introductionmentioning

confidence: 99%

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Filamentous Fungal Human Pathogens from Food Emphasising Aspergillus, Fusarium and Mucor

Paterson

Lima

2017

Microorganisms

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Disease caused by filamentous fungal human pathogens (FFHP) is increasing. These organisms cause severe mycoses in immunosuppressed individuals, such as those: (a) with AIDS; (b) having undergone transplantation; and/or (c) undergoing chemotherapy. Immunocompetent people can become infected. Some FFHP are isolated from foods which may be fomites. However, the information concerning particular species on specific food is large, dispersed and difficult to obtain. Reports of filamentous fungi from food/crops and causing human disease are frequently only available in the literature of food mycology/plant pathology and medical mycology, respectively: it is seldom cross-referenced. Aspergillus contains some species with strains that are the most dangerous FFHP, with Aspergillus fumigatus causing the most serious diseases. Fusarium and Mucor also contain species of high importance and approximately 15 other genera are involved. A checklist and database of FFHP species isolated from food is presented herein with emphasis on Aspergillus, Fusarium and Mucor in summary tables to increase awareness of the connection between food and FFHP. Metadata on all FFHP is provided in a large supplementary table for updating and revision when necessary. Previous names of fungi have been revised to reflect current valid usage whenever appropriate. The information will form a foundation for future research and taxonomic revisions in the field. The paper will be highly useful for medical practitioners, food mycologists, fungal taxonomists, patients, regulators and food producers interested in reducing infectious diseases and producing high quality food.

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Impact of Infection on Transplant Outcomes: Transplant Infectious Disease Expertise as an Essential Component of Transplant Programs

Morris¹

2020

Emerging Transplant Infections

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Infectious complications are a major cause of morbidity and mortality in both solid organ and hematopoietic stem cell transplant patients. The risk of infection by common opportunistic pathogens like cytomegalovirus can be mitigated with the optimal use of molecular diagnostics and antiviral prophylaxis. Novel and emerging bacterial, viral, fungal, and parasitic pathogens may be more successfully managed with early diagnosis and therapy. In the care of solid organ and hematopoietic stem cell transplant candidates and recipients, involvement of physicians with expertise in transplant infectious diseases has been shown to improve outcomes. In addition to their essential role in decreasing patient morbidity and mortality, infectious disease specialists also add value to the transplant program through the development and implementation of infection prevention protocols. These specialists are on the front line of the response to new organisms that may present atypically or be difficult to recognize in patients receiving immunosuppressive therapies pre-and post-transplant. In this rapidly changing field, the Emerging Transplant Infections textbook provides updated information on the diagnosis, treatment, and prevention of significant infections often seen in this highly immunocompromised population.

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Our recommendations for avoiding exposure to fungi outside the hospital for patients with haematological cancers

Cited by 16 publications

References 51 publications

Thermophilic Fungi to Dominate Aflatoxigenic/Mycotoxigenic Fungi on Food under Global Warming

Thermophilic Fungi to Dominate Aflatoxigenic/Mycotoxigenic Fungi on Food under Global Warming

Filamentous Fungal Human Pathogens from Food Emphasising Aspergillus, Fusarium and Mucor

Impact of Infection on Transplant Outcomes: Transplant Infectious Disease Expertise as an Essential Component of Transplant Programs

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